Gonadorelina este un analog sintetic de hormon peptidic, chimic o decapeptid\u0103 liniar\u0103 cu un piroglutamat \u0219i o grupare terminal\u0103 glicinamid\u0103. \u00cen cercetarea \u0219tiin\u021bific\u0103, este studiat\u0103 ca un compus model pentru semnalizarea receptorilor prin intermediul receptorilor cupla\u021bi cu proteina G \u0219i ca standard de referin\u021b\u0103 \u00een lucr\u0103rile analitice. Acest compus este oferit sub form\u0103 de kit liofilizat de 2 mg cu accesorii pentru spray nazal, exclusiv pentru scopuri de laborator \u0219i cercetare.<\/p>\n
Gonadorelin\u0103 (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub>Gonadorelina este o decapeptid\u0103 a c\u0103rei secven\u021b\u0103 de aminoacizi este identic\u0103 cu cea a hormonului endogen de eliberare a gonadotropinei (GnRH). Lan\u021bul este terminat la cap\u0103tul N-terminal de un reziduu de piroglutamat, iar la cap\u0103tul C-terminal de o func\u021bie glicinamid\u0103. Ambele modific\u0103ri protejeaz\u0103 molecula de degradarea de c\u0103tre exopeptidaze \u0219i, \u00eempreun\u0103 cu nucleul aromatic His-Trp, determin\u0103 orientarea spa\u021bial\u0103 necesar\u0103 pentru recunoa\u0219terea receptorului. Aceast\u0103 secven\u021b\u0103 scurt\u0103 \u0219i complet caracterizat\u0103 face din Gonadorelina un compus model utilizat pe scar\u0103 larg\u0103 \u00een cercetarea receptorilor peptidici.<\/p>\n \u00cen modelele de cercetare, Gonadorelinul se leag\u0103 de receptorul GnRH, un receptor cuplat cu proteina G de clasa A, care este exprimat \u00een modelele celulare gonadotrope. In vitro, aceast\u0103 legare duce la cuplarea cu Gq\/11<\/sub>-proteine, activarea fosfolipazei C \u0219i formarea de inozitol trifosfat \u0219i diacilglicerol, dup\u0103 care cre\u0219te concentra\u021bia intracelular\u0103 de calciu \u0219i se activeaz\u0103 proteina kinaza C. \u00cen mod caracteristic, modelele celulare r\u0103spund diferit la expunerea pulsatil\u0103 fa\u021b\u0103 de cea continu\u0103: cu ocuparea sus\u021binut\u0103 a receptorilor, are loc desensibilizarea in vitro \u0219i internalizarea receptorului. \u00cen consecin\u021b\u0103, Gonadorelinul este utilizat ca compus model \u0219i substan\u021b\u0103 de referin\u021b\u0103 \u00een cercetarea \u0219tiin\u021bific\u0103.<\/p>\n \u00centr-un context de laborator, Gonadorelinul este prezent \u00een urm\u0103toarele domenii de cercetare, printre altele:<\/p>\n Fiecare dintre aceste aplica\u021bii implic\u0103 cercetare controlat\u0103 de laborator sau pe modele preclinice.<\/p>\n Gonadorelin falls under the category of freeze-dried investigational peptides in our range, which are assembled as a complete kit with nasal spray accessories. While Gonadorelin targets a G-protein-coupled peptide receptor with a phospholipase C-mediated pathway, other components within the same product line have been specifically chosen to cover receptor families with an aberrant signaling cascade or enzymatic targets. These compounds share the freeze-dried kit format but differ fundamentally in molecular class, sequence length, and investigated mechanism.<\/p>\n Gonadorelin is supplied as 2 mg freeze-dried lyophilisate in a sealed vial. The kit also contains an ampoule of sterile physiological saline solution and an empty spray bottle. Unlike a solid tablet form, this is a freeze-dried preparation, for which dissolution in an aqueous medium is part of the laboratory preparation.<\/p>\n Store the unopened vial in a cool, dry place, protected from direct light, in the original packaging; after reconstitution, the material should be stored refrigerated at 2\u20138 \u00b0C. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n The lyophilisate is offered with a controlled purity of \u2265 99% (HPLC). The supplied saline solution is a sterile physiological sodium chloride solution, which serves as an inert aqueous medium in laboratory preparation.<\/p>\nDomenii de cercetare<\/h2>\n
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Gonadorelin \u00een sortimentul nostru de cercetare<\/h2>\n
Specifica\u021bii<\/h2>\n
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\n \nSpecifica\u021bii<\/th>\n Valoare<\/th>\n<\/tr>\n<\/thead>\n \n E\u015fantion<\/td>\n Gonadorelin\u0103<\/td>\n<\/tr>\n \n Sinonime<\/td>\n pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub>; gonadotropin-releasing hormone (GnRH); LHRH; luliberine<\/td>\n<\/tr>\n \n Num\u0103r CAS<\/td>\n 33515-09-2<\/td>\n<\/tr>\n \n Formula molecular\u0103 \/ greutate<\/td>\n C55<\/sub>H75<\/sub>N17<\/sub>O13<\/sub> \/ 1182,3 Da<\/td>\n<\/tr>\n \n ID-ul PubChem<\/td>\n 638793<\/td>\n<\/tr>\n \n Clas\u0103<\/td>\n Synthetic decapeptide, agonist of the GnRH receptor<\/td>\n<\/tr>\n \n Form\u0103<\/td>\n Freeze-dried lyophilisate in vial, supplied as a kit with nasal spray accessories<\/td>\n<\/tr>\n \n Cantitate per unitate<\/td>\n 2 mg<\/td>\n<\/tr>\n \n Depozitare<\/td>\n Store freeze-dried in a cool, dark place; after dissolving, refrigerate at 2\u20138 \u00b0C.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Form\u0103, manipulare \u0219i depozitare<\/h2>\n
Compozi\u021bie \u0219i rezultate de laborator<\/h2>\n