GHK-Cu este o metalopeptid\u0103 natural\u0103, chimic un complex de coordonare al tripeptidei glicil-L-histidil-L-lizin\u0103 cu un ion de cupru(II). \u00cen cercetarea \u0219tiin\u021bific\u0103, este studiat\u0103 ca un compus model pentru chimia coordon\u0103rii metal-peptid\u0103 \u0219i ca standard de referin\u021b\u0103 \u00een lucr\u0103rile analitice. Acest compus este oferit sub form\u0103 de kit care con\u021bine 100 mg de liofilizat liofilizat \u0219i materiale de laborator asociate, exclusiv pentru scopuri de laborator \u0219i cercetare.<\/p>\n
GHK-Cu (glicil-L-histidil-L-lizin\u0103-cupru(II), denumit \u00een literatura de specialitate \u0219i tripeptid\u0103-1 de cupru sau prezatid\u0103-cupru) const\u0103 dintr-un lan\u021b scurt de glicin\u0103, histidin\u0103 \u0219i lizin\u0103 care coordoneaz\u0103 \u00eempreun\u0103 un ion de cupru(II). Ionul metalic este legat prin inelul imidazol al histidinei, gruparea amino terminal\u0103 a glicinei \u0219i leg\u0103tura peptidic\u0103 intermediar\u0103; tripeptida liber\u0103 \u00een sine are formula C14<\/sub>H24<\/sub>N6<\/sub>O4<\/sub> (340,38 Da). Aceast\u0103 coordonare bine definit\u0103 face din compus un sistem model utilizat pe scar\u0103 larg\u0103 \u00een chimia bioanorganic\u0103: suficient de stabil pentru a fi izolat, suficient de labil pentru a studia transferul de cupru \u00een mod m\u0103surabil.<\/p>\n \u00cen modelele de cercetare, GHK-Cu este investigat \u00een principal \u00een rolul s\u0103u de purt\u0103tor de cupru. In vitro, complexul func\u021bioneaz\u0103 ca un rezervor interschimbabil din care cuprul(II) este transferat c\u0103tre proteinele care leag\u0103 cuprul \u0219i enzimele dependente de cupru, cum ar fi lizil oxidaza \u0219i superoxid dismutaza; chimia redox a ionului metalic legat este un domeniu recurent de interes \u00een sistemele f\u0103r\u0103 celule. \u00cen modelele celulare, sunt cartografiate profilurile de expresie genic\u0103, \u00een care partea peptidic\u0103 \u0219i ionul metalic stau opuse una fa\u021b\u0103 de cealalt\u0103 ca variabile separate. \u00cen consecin\u021b\u0103, GHK-Cu este utilizat \u00een cercetarea \u0219tiin\u021bific\u0103 ca compus model \u0219i substan\u021b\u0103 de referin\u021b\u0103.<\/p>\n \u00centr-un context de laborator, GHK-Cu apare \u00een urm\u0103toarele domenii de cercetare, printre altele:<\/p>\n Fiecare dintre aceste aplica\u021bii implic\u0103 cercetare controlat\u0103 de laborator sau pe modele preclinice.<\/p>\n GHK-Cu falls under the category of nasal spray kits within our range: formulations in which a freeze-dried lyophilisate, a sterile saline solution, and an empty spray bottle are supplied as a single complete set. While GHK-Cu focuses on the coordination and transfer of a metal ion, other components within the same product line have been specifically chosen to cover receptor-bound or enzymatic targets. They share the kit format but differ fundamentally in molecular class and investigated mechanism.<\/p>\n The kit contains 100 mg GHK-Cu as freeze-dried lyophilisate in a sealed vial, together with a sterile saline solution and an empty spray bottle. Unlike solid tablet forms, reconstitution is required for a lyophilisate: the material is dissolved prior to analytical work. The powder is light blue to blue-violet, characteristic of copper(II) peptide complexes.<\/p>\n Store the unopened vial in a cool, dry, and dark place in the original packaging; in dissolved form, the material should be kept refrigerated at 2\u20138 \u00b0C. Handle the compound with the usual laboratory precautions: work in a clean environment, use appropriate protective equipment, and prevent cross-contamination. Metallopeptides are sensitive to repeated temperature changes. Keep the kit out of reach of unauthorized persons.<\/p>\n The lyophilisate in this kit has a controlled purity of \u2265 99% (HPLC). The saline solution and the spray bottle are laboratory accessories and do not contain any active compound themselves.<\/p>\nDomenii de cercetare<\/h2>\n
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GHK-Cu \u00een cadrul sortimentului nostru de cercetare<\/h2>\n
Specifica\u021bii<\/h2>\n
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\n \nSpecifica\u021bii<\/th>\n Valoare<\/th>\n<\/tr>\n<\/thead>\n \n E\u015fantion<\/td>\n GHK-Cu<\/td>\n<\/tr>\n \n Sinonime<\/td>\n Glicil-L-histidil-L-lizin\u0103-cupru(II); tripeptid\u0103-1 de cupru; prezatid\u0103 de cupru<\/td>\n<\/tr>\n \n Num\u0103r CAS<\/td>\n 89030-95-5 (complex de cupru); 49557-75-7 (tripeptid\u0103 liber\u0103)<\/td>\n<\/tr>\n \n Formula molecular\u0103 \/ greutate<\/td>\n C14<\/sub>H23<\/sub>CuN6<\/sub>O4<\/sub> (cation) \/ 402,92 Da<\/td>\n<\/tr>\n \n ID-ul PubChem<\/td>\n 71587328 (complex de cupru); 73587 (tripeptid\u0103 liber\u0103)<\/td>\n<\/tr>\n \n Clas\u0103<\/td>\n Complex tripeptidic-cupru(II) (metalopeptid\u0103)<\/td>\n<\/tr>\n \n Form\u0103<\/td>\n Kit: freeze-dried lyophilisate, saline solution and spray bottle<\/td>\n<\/tr>\n \n Cantitate per unitate<\/td>\n 100 mg per vial<\/td>\n<\/tr>\n \n Num\u0103r de buc\u0103\u021bi per ambalaj<\/td>\n 1 complete kit<\/td>\n<\/tr>\n \n Depozitare<\/td>\n Freeze-dried, cool and dark; in dissolved form refrigerated at 2\u20138 \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Form\u0103, manipulare \u0219i depozitare<\/h2>\n
Compozi\u021bie \u0219i rezultate de laborator<\/h2>\n