{"id":2174,"date":"2026-09-01T08:43:06","date_gmt":"2026-09-01T08:43:06","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2174"},"modified":"2026-09-02T12:19:42","modified_gmt":"2026-09-02T12:19:42","slug":"ss-31-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/ro\/product\/ss-31-vial-10-mg\/","title":{"rendered":"Flacon SS-31 10 mg"},"content":{"rendered":"<p>SS-31 is een synthetisch peptide uit de klasse van de mitochondriaal gerichte, aromatisch-kationische tetrapeptiden, chemisch een tetrapeptide-amide met een alternerend aromatisch-kationisch motief. Binnen wetenschappelijk onderzoek wordt het bestudeerd als modelverbinding voor mitochondriale membraanbiofysica en als referentiestandaard in analytisch werk. Deze verbinding wordt aangeboden als gevriesdroogd poeder van 10\u00a0mg per vial, uitsluitend voor laboratorium- en onderzoeksdoeleinden.<\/p>\n<h2>Ce este SS-31?<\/h2>\n<p>SS-31 (Elamipretid\u0103, cod de dezvoltare MTP-131) este o peptid\u0103 sintetic\u0103 de dimensiuni mici cu secven\u021ba D-Arg-Dmt-Lys-Phe-NH<sub>2<\/sub>, unde Dmt reprezint\u0103 2\u2032,6\u2032-dimetiltirozin\u0103, iar cap\u0103tul C-terminal este re\u021binut de amid\u0103. Cele patru reziduuri alterneaz\u0103 ca \u0219i caracter: dou\u0103 reziduuri bazice, \u00eenc\u0103rcate pozitiv (D-arginin\u0103 \u0219i lizin\u0103) sunt opuse a dou\u0103 reziduuri aromatice. Acest model alternativ aromatic-cationic confer\u0103 moleculei o sarcin\u0103 net\u0103 pozitiv\u0103 la pH fiziologic, \u00een combina\u021bie cu suprafe\u021be hidrofobe pronun\u021bate, \u0219i tocmai aceast\u0103 semn\u0103tur\u0103 dual\u0103 face din SS-31 o molecul\u0103 model utilizat\u0103 pe scar\u0103 larg\u0103 \u00een studiul interac\u021biunilor peptid\u0103-membran\u0103.<\/p>\n<p>\u00cen modelele de cercetare, SS-31 este studiat \u00een principal pentru afinitatea sa selectiv\u0103 pentru cardiolipin\u0103, un fosfolipid anionic care se g\u0103se\u0219te aproape exclusiv \u00een membrana mitocondrial\u0103 intern\u0103. Aceast\u0103 legare se bazeaz\u0103 pe dou\u0103 for\u021be care ac\u021bioneaz\u0103 simultan: atrac\u021bia electrostatic\u0103 dintre reziduurile cationice \u0219i grup\u0103rile de cap \u00eenc\u0103rcate negativ ale cardiolipinei \u0219i inser\u021bia hidrofob\u0103 a lan\u021burilor laterale aromatice \u00een stratul lipidic. In vitro, s-a descris c\u0103 aceast\u0103 interac\u021biune influen\u021beaz\u0103 \u00eempachetarea membranei \u0219i, \u00een consecin\u021b\u0103, organizarea complexelor proteice ancorate \u00een aceasta, inclusiv supercomplexele lan\u021bului respirator. Prin urmare, SS-31 este utilizat ca compus model \u0219i substan\u021b\u0103 de referin\u021b\u0103 \u00een cercetarea \u0219tiin\u021bific\u0103.<\/p>\n<h2>Domenii de cercetare<\/h2>\n<p>\u00centr-un context de laborator, SS-31 apare \u00een urm\u0103toarele domenii de cercetare, printre altele:<\/p>\n<ul>\n<li>Cercetare biofizic\u0103 privind legarea peptidelor cationice la cardiolipin\u0103 \u00een liposomi \u0219i modele de membrane artificiale.<\/li>\n<li>Studii model privind stabilitatea supercomplexelor lan\u021bului respirator mitocondrial \u00een mitocondriile izolate.<\/li>\n<li>Investigarea enzimologic\u0103 a activit\u0103\u021bii peroxidazei complexului cardiolipin\u0103-citocrom c in vitro.<\/li>\n<li>Studiu structur\u0103-activitate \u00een care motivul alternativ aromatic-cationic este comparat cu analogi modifica\u021bi.<\/li>\n<li>Dezvoltarea \u0219i validarea metodelor analitice (HPLC, LC-MS) utiliz\u00e2nd SS-31 ca standard de referin\u021b\u0103 pentru tetrapeptide.<\/li>\n<li>Studii de stabilitate \u0219i solubilitate ale peptidelor liofilizate cu D-aminoacizi \u00een condi\u021bii controlate.<\/li>\n<\/ul>\n<p>Fiecare dintre aceste aplica\u021bii implic\u0103 cercetare controlat\u0103 de laborator sau pe modele preclinice.<\/p>\n<h2>SS-31 \u00een gama noastr\u0103 de cercetare<\/h2>\n<p>SS-31 se \u00eencadreaz\u0103 \u00een categoria peptidelor de cercetare liofilizate sub form\u0103 de flacon din gama noastr\u0103. Cercet\u0103torii care lucreaz\u0103 cu aceast\u0103 categorie combin\u0103 frecvent compusul cu alte peptide care au propria lor \u021bint\u0103 biochimic\u0103. \u00cen timp ce SS-31 se concentreaz\u0103 pe interac\u021biunea cu un fosfolipid specific din membran\u0103, alte componente din aceea\u0219i linie de produse au fost alese special pentru a acoperi \u021bintele legate de receptori sau enzimatice. Ace\u0219ti compu\u0219i au \u00een comun forma de flacon liofilizat, dar difer\u0103 fundamental prin secven\u021ba de aminoacizi \u0219i mecanismul investigat.<\/p>\n<h2>Specifica\u021bii<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifica\u021bii<\/th>\n<th>Valoare<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>E\u015fantion<\/td>\n<td>SS-31<\/td>\n<\/tr>\n<tr>\n<td>Sinonime<\/td>\n<td>Elamipretid\u0103; MTP-131; D-Arg-Dmt-Lys-Phe-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Num\u0103r CAS<\/td>\n<td>736992-21-5<\/td>\n<\/tr>\n<tr>\n<td>Formula molecular\u0103 \/ greutate<\/td>\n<td>C<sub>32<\/sub>H<sub>49<\/sub>N<sub>9<\/sub>O<sub>5<\/sub> \/ 639,8 Da<\/td>\n<\/tr>\n<tr>\n<td>ID-ul PubChem<\/td>\n<td>11764719<\/td>\n<\/tr>\n<tr>\n<td>Clas\u0103<\/td>\n<td>Tetrapeptid\u0103 aromatic-cationic\u0103 sintetic\u0103<\/td>\n<\/tr>\n<tr>\n<td>Form\u0103<\/td>\n<td>Liofilizat (pulbere liofilizat\u0103)<\/td>\n<\/tr>\n<tr>\n<td>Cantitate per flacon<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Depozitare<\/td>\n<td>A se p\u0103stra la frigider, ferit de lumin\u0103 \u0219i umiditate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Form\u0103, manipulare \u0219i depozitare<\/h2>\n<p>SS-31 wordt geleverd als gevriesdroogd, wit tot gebroken wit poeder in een afgesloten glazen vial met een gestandaardiseerde hoeveelheid van 10\u00a0mg. Dit lyofilisaat is bedoeld om in een laboratoriumopstelling in een geschikt oplosmiddel te worden opgenomen voordat verdere analyse plaatsvindt. Het poeder is hygroscopisch en neemt bij blootstelling aan omgevingslucht vocht op.<\/p>\n<p>A se p\u0103stra flaconul \u00eenchis la frigider, ferit de lumina direct\u0103 \u0219i umiditate, \u00een ambalajul original. Manipula\u021bi conexiunea respect\u00e2nd precau\u021biile standard de laborator: lucra\u021bi \u00eentr-un mediu curat, l\u0103sa\u021bi flaconul s\u0103 ating\u0103 temperatura camerei \u00eenainte de deschidere pentru a minimiza condensul, utiliza\u021bi echipament individual de protec\u021bie adecvat \u0219i preveni\u021bi contaminarea \u00eencruci\u0219at\u0103 cu alte materiale de cercetare. A nu se l\u0103sa la \u00eendem\u00e2na persoanelor neautorizate.<\/p>\n<h2>Compozi\u021bie \u0219i rezultate de laborator<\/h2>\n<p>Pentru acest liofilizat, se men\u021bine o puritate controlat\u0103 de \u2265 99% (HPLC), identitatea fiind confirmat\u0103 prin documenta\u021bia analitic\u0103 \u00eenso\u021bitoare.<\/p>\n<p>Pute\u021bi g\u0103si o prezentare general\u0103 a documenta\u021biei analitice disponibile pe site-ul nostru <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">pagina cu rezultate de laborator<\/a>Rapoartele sunt colectate centralizat acolo, astfel \u00eenc\u00e2t s\u0103 pute\u021bi \u00eencorpora datele \u00een propriile \u00eenregistr\u0103ri de cercetare.<\/p>\n<h2>\u00centreb\u0103ri frecvente<\/h2>\n<p><strong>C\u0103rei clase de substan\u021be \u00eei apar\u021bine SS-31?<\/strong><br \/>SS-31 este o tetrapeptid\u0103 sintetic\u0103 cu un motiv aromatic-cationic alternant \u0219i o amid\u0103 C-terminal\u0103, cu o secven\u021b\u0103 de aminoacizi definit\u0103 de patru reziduuri.<\/p>\n<p><strong>Care este rolul cardiolipinei \u00een acest studiu?<\/strong><br \/>Cardiolipina este fosfolipida anionic\u0103 de care SS-31 se leag\u0103 selectiv in vitro. Aceast\u0103 legare este punctul central al cercet\u0103rilor mecanistice de laborator privind organizarea complexelor proteice legate de membran\u0103 \u00een sisteme model.<\/p>\n<p><strong>De ce con\u021bine secven\u021ba D-arginin\u0103 \u0219i o tirozin\u0103 metilat\u0103?<\/strong><br \/>Ambele modific\u0103ri fac peptida mai pu\u021bin susceptibil\u0103 la degradarea enzimatic\u0103 in vitro \u0219i influen\u021beaz\u0103 distribu\u021bia sarcinii \u00een cadrul moleculei. Prin urmare, compusul serve\u0219te drept punct de referin\u021b\u0103 stabil \u00een studiile structur\u0103-activitate.<\/p>\n<p><strong>Cum se p\u0103streaz\u0103 pulberea liofilizat\u0103?<\/strong><br \/>A se p\u0103stra la frigider, ferit de lumin\u0103 \u0219i umiditate, de preferin\u021b\u0103 \u00een flaconul original sigilat. A se evita schimb\u0103rile repetate de temperatur\u0103 \u0219i condensul.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong>SS-31<\/strong>, cunoscut \u0219i sub numele de <strong>Elamipretid\u0103<\/strong>SS-31 este o tetrapeptid\u0103 sintetic\u0103 cu o structur\u0103 aromatico-cationic\u0103 unic\u0103, care se acumuleaz\u0103 selectiv \u00een membrana mitocondrial\u0103 intern\u0103. \u00cen cercetare, SS-31 este studiat\u0103 pentru legarea sa la cardiolipin\u0103 \u0219i rolul s\u0103u \u00een modelele de disfunc\u021bie mitocondrial\u0103.<\/p>","protected":false},"featured_media":3272,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2174","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/comments?post=2174"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2174\/revisions"}],"predecessor-version":[{"id":2209,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2174\/revisions\/2209"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media\/3272"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media?parent=2174"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_brand?post=2174"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_cat?post=2174"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_tag?post=2174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}