Glutathione (GSH) is a naturally occurring tripeptide, chemically a thiol-containing \u03b3-glutamyl peptide. In scientific research, it is studied as a model compound for redox biochemistry and enzymology and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 1500 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
Glutathione (\u03b3-L-glutamyl-L-cysteinyl-glycine) is a tripeptide composed of the amino acids glutamic acid, cysteine, and glycine, with the sequence \u03b3-Glu-Cys-Gly. It is characterized by an unusual \u03b3-peptide bond: the glutamate residue is linked to cysteine \u200b\u200bvia its side chain rather than the \u03b1-carboxyl group, making the molecule resistant to most common aminopeptidases. The free thiol group of the cysteine \u200b\u200bresidue forms the reactive core. It is precisely this combination of an atypical peptide bond and a free sulfhydryl that makes glutathione a widely used model molecule in peptide chemistry and thiol biochemistry.<\/p>\n
In research models, the compound plays a central role in the GSH\/GSSG redox couple: in vitro, two GSH molecules can form a disulfide bridge to the oxidized dimer GSSG, which is then converted back to the reduced form by NADPH-dependent glutathione reductase. Additionally, in cell models, glutathione acts as a cofactor for glutathione peroxidases and as a substrate for glutathione S-transferases, which couple the thiol group to nonpolar electrophiles. Biosynthesis proceeds in two ATP-dependent steps via glutamate cysteine \u200b\u200bligase and glutathione synthetase, together forming the core of the \u03b3-glutamyl cycle. Consequently, glutathione is used as a model compound and reference substance in scientific research.<\/p>\n
In a laboratory context, glutathione occurs in the following research areas, among others:<\/p>\n
Cada uma destas aplica\u00e7\u00f5es envolve investiga\u00e7\u00e3o controlada em laborat\u00f3rio ou em modelos pr\u00e9-cl\u00ednicos.<\/p>\n
Glutathione falls under the category of freeze-dried research peptides in vial form within our range. Researchers working with this category frequently combine the compound with other peptides studied via their own biochemical targets. While Glutathione focuses on thiol chemistry and redox-dependent enzyme systems, other components within the same product line have been specifically chosen to cover receptor-linked or signal-mediated targets. These compounds share the freeze-dried vial form but differ fundamentally in amino acid composition and investigated mechanism.<\/p>\n
| Especifica\u00e7\u00e3o<\/th>\n | Valor<\/th>\n<\/tr>\n<\/thead>\n | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Amostra<\/td>\n | Glutathione (GSH)<\/td>\n<\/tr>\n | ||||||||||
| Sin\u00f4nimos<\/td>\n | \u03b3-L-glutamyl-L-cysteinyl-glycine; L-glutathione (reduced); \u03b3-Glu-Cys-Gly<\/td>\n<\/tr>\n | ||||||||||
| N\u00famero CAS<\/td>\n | 70-18-8<\/td>\n<\/tr>\n | ||||||||||
| F\u00f3rmula molecular \/ peso<\/td>\n | C10<\/sub>H17<\/sub>N3<\/sub>O6<\/sub>S \/ 307.33 Da<\/td>\n<\/tr>\n| PubChem CID<\/td>\n | 124886<\/td>\n<\/tr>\n | Classe<\/td>\n | Tripeptide, thiol-containing \u03b3-glutamyl peptide<\/td>\n<\/tr>\n | Forma<\/td>\n | Liofilizado (p\u00f3 liofilizado)<\/td>\n<\/tr>\n | Quantidade por frasco<\/td>\n | 1500 mg<\/td>\n<\/tr>\n | Armazenar<\/td>\n | Manter refrigerado, protegido da luz e da humidade.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n | Formato, manuseamento e armazenamento<\/h2>\nGlutathione is supplied as a freeze-dried powder in a sealed glass vial containing a standardized quantity of 1500 mg. Unlike a solid tablet form, this lyophilisate is intended to be dissolved in a suitable solvent in a laboratory setup before analytical work takes place. The free thiol group is susceptible to oxidation to GSSG in solution; therefore, the compound is offered in freeze-dried form.<\/p>\n Store the vial refrigerated, protected from direct light and moisture, in the original packaging and with the seal intact. Handle the connection with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Avoid repeated temperature changes and keep the packaging out of reach of unauthorized persons.<\/p>\n Composi\u00e7\u00e3o e resultados laboratoriais<\/h2>\nThe lyophilisate contains glutathione with a controlled purity of \u2265 99% (HPLC). The vial contains exclusively the freeze-dried compound, without added excipients or preservatives.<\/p>\n |