GHRP-2 (Growth Hormone Releasing Peptide-2), also known as Pralmorelin, is a synthetic hexapeptide (a chain of six amino acids) and an agonist of the ghrelin receptor (GHSR-1a). It belongs to the class of growth hormone secretagogues (GH secretagogues: molecules that activate the release of growth hormone from the pituitary gland in research models) and is used in scientific research as a model compound for the neuroendocrine growth hormone axis. GHRP-2 is offered exclusively for laboratory and research purposes.<\/p>\n
GHRP-2 is one of the early, fully synthetic peptide secretagogues that plays a central role in research into the hypothalamus-pituitary axis. The compound is composed of the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2, in which the non-natural D-amino acids and the modified naphthylalanine residue ensure high stability and strong affinity for the target receptor. Unlike a growth hormone-releasing hormone (GHRH) analog, GHRP-2 acts via the ghrelin receptor GHSR-1a \u2014 the same receptor to which the body's own hormone ghrelin binds. Consequently, GHRP-2 is also described in the literature as a ghrelin mimetic: a small molecule that mimics the binding site of a larger, natural signaling molecule.<\/p>\n
Due to this receptor selectivity, GHRP-2 is a widely used reference compound in preclinical and analytical work. Researchers employ it to characterize receptor binding, to study signal transduction via the GHSR-1a pathway, and to compare it with new secretagogues. Its relatively short biological half-life and good solubility after reconstitution make it practical to handle in controlled laboratory settings.<\/p>\n
In the scientific literature, GHRP-2 primarily occurs within the following research contexts:<\/p>\n
GHRP-2 belongs to a broader family of peptide secretagogues that all act via the ghrelin receptor, but differ from one another in structure, potency, and receptor profile. The most closely related is GHRP-6 10 mg<\/a>, the original hexapeptide secretagogue from which this series originated; GHRP-2 is a structurally optimized variant of it. Ipamorelina 10 mg<\/a> is often cited in comparative studies because it is considered more selective for the GH route, while Heksarelina 10 mg<\/a> is a closely related, potent hexapeptide that also targets the GHSR-1a receptor.<\/p>\n In addition to these ghrelin receptor agonists, GHRP-2 is frequently paired with a GHRH analogue in study designs, such as CJC-1295 bez DAC 10 mg<\/a>These two mechanisms\u2014ghrelin receptor versus GHRH receptor\u2014are investigated in the literature as complementary targets on the growth hormone axis. Such comparisons help to map the role of each individual molecule in neuroendocrine signaling more accurately.<\/p>\nSpecyfikacje<\/h2>\n
| Specyfikacja<\/th>\n | Warto\u015b\u0107<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Pr\u00f3bka<\/td>\n | GHRP-2 (Pralmorelin)<\/td>\n<\/tr>\n |
| Synonimy<\/td>\n | Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102<\/td>\n<\/tr>\n |
| Numer CAS<\/td>\n | 158861-67-7<\/td>\n<\/tr>\n |
| Wz\u00f3r cz\u0105steczkowy \/ masa<\/td>\n | C\u2084\u2085H\u2085\u2085N\u2089O\u2086 \/ 817.9 g\/mol<\/td>\n<\/tr>\n |
| Identyfikator CID PubChem<\/td>\n | 6918245<\/td>\n<\/tr>\n |
| Sekwencja<\/td>\n | D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2<\/td>\n<\/tr>\n |
| Formularz<\/td>\n | 10 mg lyophilized powder (dry powder) per vial<\/td>\n<\/tr>\n |
| Czysto\u015b\u0107<\/td>\n | \u2265 99% (HPLC)<\/td>\n<\/tr>\n |
| Sk\u0142adowanie<\/td>\n | Przechowywa\u0107 w lod\u00f3wce, chroni\u0107 przed \u015bwiat\u0142em i wilgoci\u0105.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nKszta\u0142t, obs\u0142uga i przechowywanie<\/h2>\nGHRP-2 is supplied as sterile freeze-dried powder (lyophilisate) in a 10 mg vial. In freeze-dried form, the peptide is stable; keep the closed vial refrigerated and protected from light and moisture. For use in a research setup, the lyophilisate is dissolved (reconstituted) in a suitable solvent, after which the solution is stored refrigerated and used within a limited period to limit degradation. Work with clean equipment and avoid repeated temperature changes. These handling guidelines apply exclusively to the laboratory context and do not constitute instructions for use in humans or animals.<\/p>\n Czysto\u015b\u0107 i wyniki bada\u0144 laboratoryjnych<\/h2>\nGHRP-2 is offered with a controlled purity of \u2265 99%, determined via HPLC. For a current overview of the available analysis certificates and lab results, please refer to our strona z wynikami bada\u0144 laboratoryjnych<\/a>There you will find the documentation accompanying our range of research connections.<\/p>\n What exactly is GHRP-2?<\/strong> What is the difference between GHRP-2 and GHRP-6?<\/strong> How does GHRP-2 differ from a GHRH analogue?<\/strong> How should GHRP-2 be stored?<\/strong> |