SNAP-8 (Acetyl Glutamyl Octapeptide-3) is a synthetic, acetylated octapeptide whose sequence is derived from the N-terminal region of the SNAP-25 protein, a core component of the SNARE complex. It belongs to the family of acetylated peptides that are investigated as model compounds in peptide and cosmetic chemistry. Within scientific research, SNAP-8 is studied in relation to vesicular signaling and the stability of short synthetic peptides. Intended exclusively for laboratory and research purposes.<\/p>\n
SNAP-8 is an octapeptide with the amino acid sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH\u2082 (Ac-EEMQRRAD-NH\u2082 for short). The compound is an extended analog of Argirelin (Acetyl Hexapeptide-8, also called Acetyl Hexapeptide-3): whereas that molecule has six amino acids, SNAP-8 adds two extra residues (alanine and aspartic acid) to the C-terminal end. The N-terminus carries an acetyl group and the C-terminus an amide group. Both modifications increase resistance to degradation by amino- and carboxypeptidases, making SNAP-8 a structurally stable model for research on short peptides.<\/p>\n
The research importance of SNAP-8 stems from that derived sequence. Because the fragment mimics the N-terminal motif of SNAP-25, it is used in a laboratory context as a model compound to study the assembly of the SNARE complex\u2014the protein complex that drives vesicle fusion\u2014and the associated release of signaling molecules. In this sense, SNAP-8 functions as a defined, reproducible tool for mechanistic research, not as a compound with an application outside the laboratory.<\/p>\n
In a laboratory context, SNAP-8 is used in the following research areas, among others:<\/p>\n
Within the range of investigational peptides with a dermatological research background, SNAP-8 stands alongside several related molecules that each model a different mechanism. GHK-Cu<\/a> is a copper tripeptide that is classically studied in models involving the extracellular matrix and collagen expression, while Matrixyl<\/a> as a palmitoyl pentapeptide features in collagen and skin research models. Whereas those two focus on matrix and synthesis pathways, SNAP-8 falls within the SNARE and signaling molecule domain, making the molecules complementary in comparative research.<\/p>\n SNAP-8 also appears as a component in a topical research formulation: the GHK-Cu and SNAP-8 Serum 30ml<\/a> combines both peptides for research into concurrent matrix and signaling molecule models. The separate SNAP-8 vial offered here is intended for researchers who wish to reconstitute and characterize the compound separately.<\/p>\nCaract\u00e9ristiques<\/h2>\n
| Sp\u00e9cification<\/th>\n | Valeur<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| \u00c9chantillon<\/td>\n | SNAP-8 (Acetyl Glutamyl Octapeptide-3)<\/td>\n<\/tr>\n |
| Synonymes<\/td>\n | Acetyl Octapeptide-3 (INCI), Acetyl Octapeptide-1<\/td>\n<\/tr>\n |
| Num\u00e9ro CAS<\/td>\n | 868844-74-0<\/td>\n<\/tr>\n |
| Formule mol\u00e9culaire \/ masse mol\u00e9culaire<\/td>\n | C\u2084\u2081H\u2087\u2080N\u2081\u2086O\u2081\u2086S \/ \u00b1 1075.2 Da<\/td>\n<\/tr>\n |
| S\u00e9quence<\/td>\n | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH\u2082 (Ac-EEMQRRAD-NH\u2082)<\/td>\n<\/tr>\n |
| Content \/ form<\/td>\n | 10 mg lyophilized powder (dry powder) per vial<\/td>\n<\/tr>\n |
| Puret\u00e9<\/td>\n | \u2265 99 % (HPLC)<\/td>\n<\/tr>\n |
| Stockage<\/td>\n | \u00c0 conserver au r\u00e9frig\u00e9rateur, \u00e0 l'abri de la lumi\u00e8re et de l'humidit\u00e9.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nForme, manipulation et stockage<\/h2>\nSNAP-8 is supplied as a freeze-dried powder (lyophilisate) of 10 mg per vial. In a research context, the lyophilisate is reconstituted with a suitable solvent such as bacteriostatic or sterile water before use; the octapeptide is highly water-soluble. Handle the powder in a cool place and protected from light and moisture, and avoid repeated freeze-thaw cycles to maintain structural integrity.<\/p>\n The dry lyophilisate is most stable when stored in a cool, dark place. After reconstitution, the solution is usually stored refrigerated (2\u20138 \u00b0C) and used within a limited period. Work with clean, calibrated materials and record the concentration and date of reconstitution so that measurements remain reproducible. In research, dosages are expressed in mg of active substance per experiment.<\/p>\n Puret\u00e9 et r\u00e9sultats de laboratoire<\/h2>\nSNAP-8 is offered with a controlled purity of \u2265 99%, determined via HPLC. This degree of purity makes the compound suitable as a defined model compound and reference standard in analytical and preclinical research. Certificates of analysis and lab results of our research compounds can be found bundled on the page de r\u00e9sultats de laboratoire<\/a>.<\/p>\n What exactly is SNAP-8?<\/strong> How does SNAP-8 differ from Argireline?<\/strong> In what form is SNAP-8 delivered?<\/strong> How do I store SNAP-8?<\/strong> |