PEG MGF (PEGylated Mechano Growth Factor) is a modified peptide variant derived from IGF-1Ec, a splice isoform (alternatively transcribed gene variant) of insulin-like growth factor 1 (IGF-1). The C-terminal 24-amino acid fragment is covalently linked to polyethylene glycol (PEGylation), a modification that increases molecular stability and circulation time compared to the unmodified peptide. In scientific research, PEG MGF is used as a model compound regarding the IGF-1 signaling pathway. Intended exclusively for laboratory and research purposes.<\/p>\n
Mechano Growth Factor (MGF) is the name for the splice isoform IGF-1Ec: the same gene locus as IGF-1, but with a unique 24-amino acid C-terminal E-peptide resulting from alternative splicing of the IGF-1 gene. This E-peptide is structurally distinct from the mature IGF-1 molecule and is treated as a standalone peptide sequence in research models. In the body, the isoform is expressed in mechanically stressed or damaged skeletal muscle tissue, which explains the historical name \u201cmechano growth factor\u201d.<\/p>\n
The addition \u201cPEG\u201d refers to PEGylation: the covalent attachment of a polyethylene glycol chain to the peptide. This polymer fraction increases the effective molecular size, slows down enzymatic degradation, and thereby extends the half-life in solution. Whereas the unmodified E-peptide is cleared very rapidly in model systems, the PEGylated form is intended to remain measurable over a longer period \u2014 a property that makes PEG MGF suitable as a more stable model compound for research into the IGF-1 axis. PEG MGF is not a growth hormone and not mature IGF-1; it consists exclusively of the modified C-terminal fragment.<\/p>\n
PEG MGF is used in preclinical and in vitro contexts as an aid to study various issues. This always concerns what is observed in research models, not application in humans or animals:<\/p>\n
PEG MGF belongs to the broader research family surrounding the growth hormone and IGF-1 axes. The most directly related product is the unmodified MGF 2mg<\/a>: the same E-peptide sequence, but without the PEGylation and therefore with a shorter model half-life. For research into the IGF-1 molecule itself, IGF-1 LR3 1 mg<\/a> a widely used extended stability analog. Where MGF variants represent the downstream fragment of the axis, secretagogues and GHRH analogs function as Tesamorelin<\/a> precisely further upstream in the same signal cascade. Together, these connections make it possible to compare different levels of the IGF-1 axis in model research.<\/p>\nSpecifications<\/h2>\n
| Specification<\/th>\n | Value<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Sample<\/td>\n | PEG MGF (PEGylated Mechano Growth Factor)<\/td>\n<\/tr>\n |
| Synonyms<\/td>\n | PEG-MGF, Pegylated MGF, PEGylated IGF-1Ec<\/td>\n<\/tr>\n |
| Structure<\/td>\n | C-terminal 24-amino acid E-peptide of IGF-1Ec (splice isoform of IGF-1)<\/td>\n<\/tr>\n |
| Core Sequence (MGF)<\/td>\n | YQPPSTNKNTKSQRRKGSTFEEHK (24 amino acids)<\/td>\n<\/tr>\n |
| Modification<\/td>\n | Covalently linked polyethylene glycol (PEGylation)<\/td>\n<\/tr>\n |
| Form<\/td>\n | Freeze-dried powder (lyophilisate), 2 mg per vial<\/td>\n<\/tr>\n |
| Purity<\/td>\n | \u2265 99% (HPLC)<\/td>\n<\/tr>\n |
| Storage<\/td>\n | Freeze-dried cool and dark; refrigerated after reconstitution<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n The molecular mass of PEG MGF cannot be given as a single fixed value: the underlying E-peptide comprises approximately 2.9 kDa, while the attached PEG fraction significantly increases the total mass depending on chain length. A single CAS number or PubChem CID for the PEGylated form has not been unambiguously established; these rules have therefore been omitted to keep the table fair.<\/p>\n Shape, handling and storage<\/h2>\nPEG MGF is supplied as a freeze-dried powder in a 2 mg vial. Before use in research, the lyophilisate is reconstituted with a suitable solvent, usually bacteriostatic water, which is added along the wall of the vial without spraying the contents directly. The vial is then gently rotated rather than shaken so that the peptide dissolves completely without mechanical stress. Store the unopened lyophilisate in a cool, dark place; after reconstitution, the solution should be stored refrigerated, and repeated freeze-thaw cycles should be avoided to limit degradation. Work in a clean, controlled research environment and record the reconstitution date and concentration for experimental reproducibility.<\/p>\n Purity and lab results<\/h2>\nPEG MGF is offered with a controlled purity of \u2265 99%, determined via HPLC analysis. Purity and identity are relevant because contaminants or degradation products can cloud the interpretation of model research. An overview of the available analyses and certificates can be found on our website. lab results page<\/a>.<\/p>\n |