GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide belonging to the class of growth hormone secretagogues (release-stimulating molecules) and an agonist of the ghrelin receptor (GHSR-1a). In scientific research, the compound is studied as a model compound in receptor binding and signal transduction research around the hypothalamus-pituitary axis. GHRP-6 is offered as a freeze-dried powder (lyophilisate) with a controlled purity of \u2265 99% (HPLC) and is intended exclusively for laboratory and research purposes.<\/p>\n
GHRP-6 is composed of six amino acids with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 and an amidated C-terminus. The compound belongs to the family of growth hormone-releasing peptides (GHRPs), a series of short synthetic peptides originally derived from met-enkephalin analogs that do not exhibit opioid activity. Two D-amino acids (D-Trp and D-Phe) in the sequence increase structural stability against proteolytic degradation, making GHRP-6 a sought-after model for studying peptide conformation and enzymatic robustness.<\/p>\n
Mechanistically, GHRP-6 is an agonist of the growth hormone secretagogue receptor type 1a (GHSR-1a), better known as the ghrelin receptor. Research models study how binding to this G-protein-coupled receptor initiates intracellular signaling cascades, including phospholipase-C- and cAMP-mediated pathways. This receptor signaling axis places GHRP-6 in a different mechanistic category from the GHRH analogs (such as sermorelin or tesamorelin), which act via the individual GHRH receptor. It is precisely this difference that makes GHRP-6 interesting as a comparison compound in receptor pharmacological research.<\/p>\n
GHRP-6 is used in a laboratory context as a model compound in the following research lines, among others:<\/p>\n
In the literature, GHRP-6 is often placed alongside other growth hormone secretagogues that target the same ghrelin receptor but differ in structure and receptor profile. GHRP-2<\/a> is the closest related hexapeptide within the same GHRP series and is often investigated together with GHRP-6 in comparative studies. Ipamorelin<\/a> is a more selective pentapeptide agonist of the ghrelin receptor and serves as a reference for research into receptor selectivity. Hexarelin<\/a> is a structurally closely related GHRP that regularly functions as a parallel model link. In research into combined signal routes, GHRP-6 is additionally compared against GHRH analogues such as CJC-1295 without DAC<\/a> set, to map the two complementary receptor axes.<\/p>\nSpecifications<\/h2>\n
| Specification<\/th>\n | Value<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Sample<\/td>\n | GHRP-6 (Growth Hormone Releasing Peptide-6)<\/td>\n<\/tr>\n |
| Synonyms<\/td>\n | Growth hormone-releasing hexapeptide, GHRP-6 acetate<\/td>\n<\/tr>\n |
| CAS number<\/td>\n | 87616-84-0<\/td>\n<\/tr>\n |
| Molecular formula \/ weight<\/td>\n | C\u2084\u2086H\u2085\u2086N\u2081\u2082O\u2086 \/ 873.01 Da<\/td>\n<\/tr>\n |
| PubChem CID<\/td>\n | 4345065<\/td>\n<\/tr>\n |
| Sequence<\/td>\n | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2<\/td>\n<\/tr>\n |
| Class<\/td>\n | Synthetic hexapeptide, ghrelin receptor agonist (GHSR-1a)<\/td>\n<\/tr>\n |
| Form<\/td>\n | Freeze-dried powder (lyophilisate), 10 mg per vial<\/td>\n<\/tr>\n |
| Purity<\/td>\n | \u2265 99% (HPLC)<\/td>\n<\/tr>\n |
| Storage<\/td>\n | Keep refrigerated, protected from light and moisture<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nShape, handling and storage<\/h2>\nGHRP-6 is supplied as a freeze-dried powder (lyophilisate) in a 10 mg vial. The dry lyophilisate is the most stable: store it refrigerated, protected from light and moisture. For investigational solution, bacteriostatic water is typically used in laboratories; after reconstitution, the solution is stored refrigerated (2\u20138 \u00b0C) and protected from repeated temperature changes. Avoid vigorous shaking and use short pipette steps to limit foaming and peptide loss from the vial wall. Additional background information on the correct preparation and dilution of powdered investigational peptides is available in the knowledge base.<\/p>\n Purity and lab results<\/h2>\nGHRP-6 is offered with a controlled purity of \u2265 99%, determined via HPLC. The identity and purity of our investigational compounds are documented; the corresponding certificates of analysis and an overview of the lab results can be consulted on our lab results page<\/a>This ensures that the analytical substantiation remains transparent and traceable for research purposes.<\/p>\n What kind of molecule is GHRP-6?<\/strong> How does GHRP-6 differ from a GHRH analogue?<\/strong> How is GHRP-6 stored?<\/strong> |