Sermorelin Acetate is a synthetic polypeptide of the class of GHRH analogs, chemically the acetate salt of a chain of 29 amino acids with a C-terminal amide function. In scientific research, it is studied as a model compound for receptor pharmacology at class B G-protein-coupled receptors and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 10 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
Sermorelin (hGHRH(1-29)NH2<\/sub>) corresponds to the N-terminal fragment of the first 29 amino acids of human growth hormone-releasing hormone, an endogenous polypeptide of 44 residues. The sequence reads Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2<\/sub>In the literature, this fragment is considered the shortest part that retains full receptor recognition; the chain folds into an amphipathic alpha-helix whose hydrophobic side forms the contact surface. This combination of a short sequence and an intact binding profile makes the compound a widely used structural model. The acetate acts as a counterion.<\/p>\n In research models, Sermorelin binds to the GHRH receptor (GHRHR), a class B G-protein-coupled receptor. In cell models, that receptor couples via Gs<\/sub> to adenylate cyclase, which in vitro leads to cAMP formation and activation of protein kinase A; this cascade is a standard yardstick in receptor assays. In addition, the compound is a classic substrate for enzymatic work: dipeptidylpeptidase-4 cleaves the N-terminal dipeptide in vitro, after which the remaining fragment exhibits a significantly reduced receptor affinity. Consequently, Sermorelin Acetate is used as a model compound and reference substance within scientific research.<\/p>\n In a laboratory context, Sermorelin Acetate occurs in the following research areas, among others:<\/p>\n Each of these applications involves controlled laboratory or preclinical model research.<\/p>\n Sermorelin Acetate falls under the category of freeze-dried peptides in vial form within our product range. Researchers regularly combine the compound with other polypeptides that are studied via their own biochemical target. While Sermorelin Acetate targets a class B G-protein-coupled receptor and the associated cAMP cascade, other components within the same product line have been selected to cover divergent receptor families or enzymatic pathways. These compounds share the freeze-dried vial form but differ in amino acid composition and investigated mechanism.<\/p>\n Sermorelin Acetate is supplied as a freeze-dried powder of 10 mg per vial. The lyophilisate is a white to off-white powder residue at the bottom of the vial. Unlike solid tablet forms, the material in its freeze-dried state is intended to be dissolved in a suitable solvent in a laboratory setup before analytical work takes place.<\/p>\n Store the closed vial in a cool, dark place, protected from light and moisture, in the original packaging. Handle the connection with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Limit temperature fluctuations. Keep the packaging out of reach of unauthorized persons.<\/p>\n A controlled purity of \u2265 99% (HPLC) is maintained for this lyophilisate. The vial contains the polypeptide as an acetate salt, without added excipients.<\/p>\nResearch areas<\/h2>\n
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Sermorelin Acetate in our research assortment<\/h2>\n
Specifications<\/h2>\n
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\n \nSpecification<\/th>\n Value<\/th>\n<\/tr>\n<\/thead>\n \n Sample<\/td>\n Sermorelin Acetate<\/td>\n<\/tr>\n \n Synonyms<\/td>\n hGHRH(1-29)NH2<\/sub>; GRF(1-29)NH2<\/sub>; Somatotropin-Releasing-Hormone(1-29)Amide<\/td>\n<\/tr>\n \n CAS number<\/td>\n 86168-78-7<\/td>\n<\/tr>\n \n Molecular formula \/ weight<\/td>\n C149<\/sub>H246<\/sub>N44<\/sub>O42<\/sub>S \/ 3357.9 Da (free base)<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 16132413<\/td>\n<\/tr>\n \n Class<\/td>\n Synthetic polypeptide, 29 amino acids, GHRH analog<\/td>\n<\/tr>\n \n Form<\/td>\n Lyophilisate (freeze-dried powder) in vial<\/td>\n<\/tr>\n \n Quantity per vial<\/td>\n 10 mg<\/td>\n<\/tr>\n \n Storage<\/td>\n Store freeze-dried in a cool, dark place, protected from light and moisture.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Shape, handling and storage<\/h2>\n
Composition and lab results<\/h2>\n