5-Amino-1MQ is a synthetic small molecule from the class of quaternary quinolinium salts, chemically a 5-amino-substituted 1-methylquinolinium. In scientific research, it is studied as a model compound for methyltransferase enzymology and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 50 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
5-Amino-1MQ (1-methylquinolin-1-ium-5-amine, supplied as an iodide salt) is a small organic molecule surrounding a bicyclic quinolin skeleton. The ring nitrogen atom bears a methyl group, giving the molecule a permanently positively charged quaternary quinolinium core; an amino group is located at position 5. This fixed charge determines its behavior in the laboratory: unlike an ionizable amine, the charge does not change with pH, \u200b\u200bmaking the molecule easy to handle in cation exchange chromatography. Additionally, the electron-rich amino substituent shifts the absorption band of the conjugated ring system and yields a distinct chromophore in the UV region. This makes the compound a widely used model molecule in the study of S-adenosylmethionine-dependent methylation reactions.<\/p>\n
In research models, 5-Amino-1MQ is used to study the enzyme nicotinamide-N-methyltransferase (NNMT). NNMT transfers a methyl group from the cofactor S-adenosylmethionine (SAM) to nicotinamide, resulting in the formation of 1-methylnicotinamide and S-adenosylhomocysteine. In vitro, 5-Amino-1MQ binds to the substrate pocket of this enzyme and is therefore described in the literature as an inhibitor of this methylation step; the charged quinolinium motif mimics the methylated pyridinium structure of the reaction product. Subsequently, the consequences for nicotinamide and NAD are investigated in cell models.+<\/sup>-recycling route and for the methyl donor pool are followed. Within scientific research, 5-Amino-1MQ is therefore used as a model compound and reference substance.<\/p>\n In a laboratory context, 5-Amino-1MQ occurs in the following research areas, among others:<\/p>\n Each of these applications involves controlled laboratory or preclinical model research.<\/p>\n 5-Amino-1MQ falls within our range under the freeze-dried investigational compounds in vial form, a category that researchers regularly combine with substances being studied via their own biochemical target. While 5-Amino-1MQ focuses on a methyltransferase and its associated cofactor homeostasis, other components within the same product line have been specifically chosen to cover receptor-linked, metal-coordinated, or peptide-mediated targets. These compounds share the freeze-dried vial form but differ fundamentally in molecular class and investigated mechanism.<\/p>\n 5-Amino-1MQ is supplied as a freeze-dried powder of 50 mg per vial, sealed under a rubber stopper with aluminium sealing. It is a quaternary ammonium salt in solid form; the material is weighed in a laboratory setup and further processed according to the applicable analytical or enzymological protocol. Hygroscopic behaviour is a known point of attention for this class of substances.<\/p>\n Store the closed vial in a cool, dark place, protected from light and moisture, preferably in the original packaging. Iodide salts are sensitive to prolonged exposure to light, which may cause a change in the powder's color. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination. Keep the packaging out of reach of unauthorized persons.<\/p>\n The lyophilisate contains 50 mg of 5-Amino-1MQ per vial with a controlled purity of \u2265 99% (HPLC). No stabilizers or fillers are added, so that the compound remains usable as a reference material in analytical work.<\/p>\nResearch areas<\/h2>\n
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5-Amino-1MQ in our research assortment<\/h2>\n
Specifications<\/h2>\n
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\n \nSpecification<\/th>\n Value<\/th>\n<\/tr>\n<\/thead>\n \n Sample<\/td>\n 5-Amino-1MQ (5-amino-1-methylquinolinium iodide)<\/td>\n<\/tr>\n \n Synonyms<\/td>\n 1-methylquinolin-1-ium-5-amine iodide; quinolinium, 5-amino-1-methyl-, iodide (1:1); NNMTi<\/td>\n<\/tr>\n \n CAS number<\/td>\n 42464-96-0<\/td>\n<\/tr>\n \n Molecular formula \/ weight<\/td>\n C10<\/sub>H11<\/sub>IN2<\/sub> \/ 286,11 Da<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 66522933<\/td>\n<\/tr>\n \n Class<\/td>\n Small molecule, quaternary quinolinium salt; inhibitor of nicotinamide-N-methyltransferase<\/td>\n<\/tr>\n \n Form<\/td>\n Freeze-dried powder (lyophilized powder) in sealed vial<\/td>\n<\/tr>\n \n Quantity per vial<\/td>\n 50 mg<\/td>\n<\/tr>\n \n Storage<\/td>\n Store in a cool, dark place, protected from light and moisture.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Shape, handling and storage<\/h2>\n
Composition and lab results<\/h2>\n