Selank is a synthetic linear heptapeptide: a chain of seven amino acid residues with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. The compound is known under CAS number 129954-34-3, with the molecular formula C33<\/sub>H57<\/sub>N11<\/sub>O9<\/sub> (approx. 751.9 g\/mol) and PubChem CID 11765600. The first four residues (Thr-Lys-Pro-Arg) form a naturally occurring tetrapeptide fragment; the tripeptide Pro-Gly-Pro is coupled to this at the C-terminus.<\/p>\n With three proline residues at seven positions, Selank is a distinctly proline-rich chain. The proline-glycine-proline sequence at the C-terminal end increases the rigidity of that part of the chain and limits attack by exopeptidases, making the sequence measurably more stable under laboratory conditions than the unextended tetrapeptide fragment. Additionally, the lysine and arginine residues ensure a distinctly basic charge profile: at neutral pH, the molecule carries a net positive charge, which largely determines its retention behavior in reverse-phase chromatography with ion-pairing additives. Moreover, the chain contains no aromatic residues whatsoever, so detection at 280 nm yields hardly any signal and is typically measured at the peptide bridge around 214 nm. This combination of a short, fully written-out sequence, a rigid C-terminus, and a sharply defined charge profile makes Selank a highly reproducible model compound in comparative peptide research.<\/p>\n Within peptide chemistry and analytical work, Selank is involved in the following in vitro research areas, among others:<\/p>\nApplications in a laboratory context<\/h2>\n
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Specifications<\/h2>\n