Kisspeptin-10 (KP-10) is the minimally active C-terminal decapeptide fragment of endogenous kisspeptin, the protein encoded by the KISS1 gene. As a ligand of the GPR54 receptor (KISS1R), kisspeptin is considered in endocrinology to be a central upstream regulator of the hypothalamic-pituitary-gonadal axis (HPG axis). Lumo Peptides offers Kisspeptin-10 exclusively as a research-grade lyophilisate (freeze-dried powder) for laboratory and preclinical research \u2014 not for human or animal use.<\/p>\n
Kisspeptin is formed in the body as a larger precursor protein that is subsequently cleaved into shorter, biologically active fragments. The shortest fragment that can still fully activate the receptor is a chain of ten amino acids: Kisspeptin-10. The sequence (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) corresponds to amino acids 45\u201354 of the metastin molecule, which is why the compound is also referred to in the literature as \u201cMetastin (45-54)\u201d or simply \u201cKP-10\u201d.<\/p>\n
In research models, Kisspeptin-10 binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus. This receptor-ligand interaction is central to the study of the neuroendocrine control of the reproductive axis: kisspeptin signaling is considered one of the key links upstream of gonadotropin-releasing hormone (GnRH, a release-stimulating hormone). As a synthetic peptide, Kisspeptin-10 makes it possible to study this pathway in a controlled and reproducible manner in vitro and in preclinical models, without relying on the complete, less stable precursor protein.<\/p>\n
Kisspeptin-10 appears in the scientific literature as an aid to investigate various molecular and physiological questions. Examples of research directions in which the peptide plays a role:<\/p>\n
Within research into the HPG axis, Kisspeptin-10 is often placed alongside other regulatory peptides that act at different levels of the same axis. Where kisspeptin stands at the top of the cascade, it works Gonadorelin 2mg<\/a> \u2014 a synthetic GnRH \u2014 one step lower and targets the pituitary gland directly. Triptorelin 2 mg<\/a> is a GnRH agonist that is specifically used in research to modulate the axis via long-term receptor occupancy, while HCG<\/a> as a gonadotropin analogue acts even further downstream. For investigational setups with a nasal spray administration form, the same active substance is also available as Kisspeptin Nasal Spray Kit<\/a>Together, these connections allow the propagation axis to be compared at multiple levels.<\/p>\nSpecifications<\/h2>\n