Isotretinoin is a synthetic retinoid, chemically a polyenecarboxylic acid and the 13-cis isomer of all-trans-retinoic acid. In scientific research, it is studied as a model compound for nuclear receptor biology and cis\/trans isomerism, and as a reference standard in analytical work. This compound is offered as tablets containing 10 mg of active substance per tablet, exclusively for laboratory and research purposes.<\/p>\n
Isotretinoin, systematic (2Z<\/em>,4E<\/em>,6E<\/em>,8E<\/em>)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-ene-1-yl)nona-2,4,6,8-tetraenoic acid, is a small organic molecule of the class of retinoids. The structure consists of a substituted cyclohexene ring (the so-called \u03b2-ionone ring), a conjugated chain of four double bonds, and a terminal carboxylic acid group. The distinguishing feature is the cis<\/em>-configuration at position 13: whereas natural all-trans-retinoic acid has a straight chain, the 13-cis geometry gives the molecule a kink and thus a deviating spatial arrangement. It is precisely this geometric similarity between two otherwise identical molecules that makes the compound a useful model for investigating how only the double-bond geometry determines binding to a protein. Additionally, the conjugated system exhibits strong absorption in the near-UV region, making the substance suitable as a calibration medium with UV detection.<\/p>\n In research models, retinoids act on the nuclear receptors RAR and RXR: ligand-activated transcription factors that bind as heterodimers to response elements in DNA and thus drive gene expression in cell models. Isotretinoin itself binds weakly to these receptors and behaves partly as a precursor compound in cell culture: intracellular isomerization yields the all-trans form, while oxidation by cytochrome P450 enzymes gives 4-oxo metabolites. This combination of non-enzymatic isomerization and enzymatic conversion makes the compound attractive for mechanistic and enzymological laboratory research. Consequently, Isotretinoin is used as a model compound and reference substance within scientific research.<\/p>\n In a laboratory context, Isotretinoin occurs in the following research areas, among others:<\/p>\n Each of these applications involves controlled laboratory or preclinical model research.<\/p>\n Isotretinoin falls under the category of oral investigational compounds in solid tablet form within our range. While Isotretinoin focuses on ligand-activated nuclear receptors and isomer geometry, other components within the same product line have been specifically chosen to cover enzymatic or membrane-bound targets. They share the solid tablet form but differ fundamentally in molecular class and investigated mechanism.<\/p>\n Isotretinoin is supplied as solid tablets containing a standardized amount of 10 mg of active substance per tablet, packaged in units of 100. This solid form is ready for immediate handling: the tablets can be weighed in a laboratory setup and further analytically processed according to the laboratory's own procedures.<\/p>\n Store the tablets dry at room temperature, protected from direct light and moisture, in the original packaging; the conjugated polyene system is sensitive to light and oxygen. Handle the compound with the usual laboratory precautions: work in a clean environment, use suitable personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n For this compound, the content is expressed as the amount of active substance per tablet (10 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations.<\/p>\nResearch areas<\/h2>\n
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Isotretinoin in our research assortment<\/h2>\n
Specifications<\/h2>\n
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\n \nSpecification<\/th>\n Value<\/th>\n<\/tr>\n<\/thead>\n \n Sample<\/td>\n Isotretinoin<\/td>\n<\/tr>\n \n Synonyms<\/td>\n 13-cis-retinoic acid; (2Z<\/em>,4E<\/em>,6E<\/em>,8E<\/em>)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid<\/td>\n<\/tr>\n \n CAS number<\/td>\n 4759-48-2<\/td>\n<\/tr>\n \n Molecular formula \/ weight<\/td>\n C20<\/sub>H28<\/sub>O2<\/sub> \/ 300.44 Da<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 5282379<\/td>\n<\/tr>\n \n Class<\/td>\n Small molecule, retinoid (polyenecarboxylic acid)<\/td>\n<\/tr>\n \n Form<\/td>\n Tablets<\/td>\n<\/tr>\n \n Amount per tablet<\/td>\n 10 mg<\/td>\n<\/tr>\n \n Number of tablets per package<\/td>\n 100<\/td>\n<\/tr>\n \n Storage<\/td>\n Store in a dry place at room temperature, protected from light and moisture.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Shape, handling and storage<\/h2>\n
Composition and lab results<\/h2>\n