CJC-1295 + Ipamorelin Pen

CJC-1295 without DAC and Ipamorelin are two synthetic peptides that each act on a specific receptor of the pituitary axis in research models. Within scientific research, they are studied together as a model pair for the interaction between two release pathways and as a reference standard in analytical work. This combination is offered as a 3 ml pre-filled injection pen containing 5 mg of each peptide, exclusively for laboratory and research purposes.

What is inside this pen?

The cartridge contains both peptides in a fixed 1:1 ratio, pre-combined in a single solution. CJC-1295 without DAC, also known in the literature as Mod GRF(1-29), is a modified fragment of 29 amino acids of the growth hormone-releasing hormone. Four amino acid substitutions at positions 2, 8, 15, and 27 make the chain more resistant to enzymatic degradation than the unmodified GRF(1-29); binding to the GHRH receptor is studied in research models.

Ipamorelin is a selective pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂ which acts on the growth hormone secretagogue receptor, also known as the ghrelin receptor. The two D-amino acids and the non-proteinogenic Aib at the start of the chain make the compound insensitive to the usual degradation pathways and provide a pronounced selectivity profile with respect to related secretagogues. Because both molecules act via a different receptor, pairing is considered in the literature as a classic model for studying the interplay between two signaling pathways.

Research areas

In a laboratory context, this combination occurs in the following research areas, among others:

• Receptor pharmacology — binding studies to the GHRH receptor and the growth hormone secretagogue receptor in cell models.
• Signal transduction — measurement of second messenger systems with simultaneous activation of both routes.
• Selectivity study — comparison with related secretagogues to determine the receptor specificity of the pentapeptide.
• Structure-activity research — the role of D-amino acids and Aib in the resistance of short chains to peptidases.
• Analytical method development — separation of two peptides from a single solution using RP-HPLC and LC-MS.
• Stability study — behavior of a two-component solution at varying pH, ionic strength, and storage temperature.

Each of these applications involves controlled laboratory or preclinical model research.

CJC-1295 + Ipamorelin in our research assortment

This version belongs to the line of pre-filled injection pens: compounds contained in dissolved form in a sealed cartridge, so that a researcher does not need to go through their own dissolution step. The same combination is available elsewhere in the range as freeze-dried lyophilisate in a vial, and both peptides are also available separately. Other compounds within the pen line act on an entirely different biochemical system; the form indicates nothing about the substance class.

Specifications

Shape, handling and storage

Both peptides are dissolved in a sealed 3 ml glass cartridge in a pen with a click mechanism. A separate dissolution step is not required with this version; the cartridge remains closed until a needle is inserted. The label includes a table showing the relationship between click settings and dispensed volume, allowing sample collections to be reproducibly recorded in a protocol.

Store the pen refrigerated between 2 and 8 °C, protected from light and in the original packaging. Handle the pen in a clean working environment, use a new sterile needle for each draw to prevent cross-contamination, and wear standard personal protective equipment. Keep the material out of reach of unauthorized persons.

Composition and lab results

Both raw materials have a controlled purity of ≥ 99% (HPLC). The pen contains the two peptides in a sterile aqueous base in a 1:1 ratio; the total amount per component is stated on the label.

Analysis certificates of the relevant parties are on our lab results page.

Frequently Asked Questions

To which class of substances do these two compounds belong?
CJC-1295 without DAC is a modified peptide fragment of 29 amino acids, derived from growth hormone-releasing hormone. Ipamorelin is a synthetic pentapeptide with two D-amino acids and an Aib residue at the start of the chain.

What does “without DAC” mean?
DAC stands for Drug Affinity Complex, a chemical additive that extends the chain circulation time in models. In the variant without DAC, this additive is absent, making the profile closer to that of the unprocessed GRF(1-29) fragment.

In what form is the combination delivered?
As a pre-filled injection pen with a sealed 3 ml cartridge containing 5 mg of both peptides. The box also contains ten sterile pen needles and alcohol wipes.

How do I store the pen?
Refrigerated between 2 and 8 °C, in a dark place and in the original packaging. Do not freeze.