Gonadorelin is a synthetic peptide hormone analog, chemically a linear decapeptide with a pyroglutamate and a glycinamide end group. In scientific research, it is studied as a model compound for receptor signaling via G-protein-coupled receptors and as a reference standard in analytical work. This compound is offered as a 2 mg freeze-dried kit with nasal spray accessories, exclusively for laboratory and research purposes.<\/p>\n
Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub>Gonadorelin is a decapeptide whose amino acid sequence is identical to that of endogenous gonadotropin-releasing hormone (GnRH). The chain is terminated at the N-terminus by a pyroglutamate residue and at the C-terminus by a glycinamide function. Both modifications protect the molecule from degradation by exopeptidases and, together with the aromatic His-Trp core, determine the spatial orientation required for receptor recognition. This short, fully characterized sequence makes Gonadorelin a widely used model compound in peptide receptor research.<\/p>\n In research models, Gonadorelin binds to the GnRH receptor, a class A G-protein-coupled receptor that is expressed in gonadotropic cell models. In vitro, this binding leads to coupling to Gq\/11<\/sub>-proteins, activation of phospholipase C and the formation of inositol triphosphate and diacylglycerol, after which the intracellular calcium concentration rises and protein kinase C is activated. Characteristically, cell models respond differently to pulsatile than to continuous exposure: with sustained receptor occupancy, in vitro desensitization and internalization of the receptor occur. Consequently, Gonadorelin is used as a model compound and reference substance in scientific research.<\/p>\n Im Laborkontext kommt Gonadorelin unter anderem in folgenden Forschungsbereichen vor:<\/p>\n Jede dieser Anwendungen beinhaltet kontrollierte Labor- oder pr\u00e4klinische Modellforschung.<\/p>\n Gonadorelin falls under the category of freeze-dried investigational peptides in our range, which are assembled as a complete kit with nasal spray accessories. While Gonadorelin targets a G-protein-coupled peptide receptor with a phospholipase C-mediated pathway, other components within the same product line have been specifically chosen to cover receptor families with an aberrant signaling cascade or enzymatic targets. These compounds share the freeze-dried kit format but differ fundamentally in molecular class, sequence length, and investigated mechanism.<\/p>\n Gonadorelin is supplied as 2 mg freeze-dried lyophilisate in a sealed vial. The kit also contains an ampoule of sterile physiological saline solution and an empty spray bottle. Unlike a solid tablet form, this is a freeze-dried preparation, for which dissolution in an aqueous medium is part of the laboratory preparation.<\/p>\n Store the unopened vial in a cool, dry place, protected from direct light, in the original packaging; after reconstitution, the material should be stored refrigerated at 2\u20138 \u00b0C. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n The lyophilisate is offered with a controlled purity of \u2265 99% (HPLC). The supplied saline solution is a sterile physiological sodium chloride solution, which serves as an inert aqueous medium in laboratory preparation.<\/p>\nForschungsgebiete<\/h2>\n
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Gonadorelin in unserem Forschungssortiment<\/h2>\n
Spezifikationen<\/h2>\n
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\n \nSpezifikation<\/th>\n Wert<\/th>\n<\/tr>\n<\/thead>\n \n Probe<\/td>\n Gonadorelin<\/td>\n<\/tr>\n \n Synonyme<\/td>\n pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub>; gonadotropin-releasing hormone (GnRH); LHRH; luliberine<\/td>\n<\/tr>\n \n CAS-Nummer<\/td>\n 33515-09-2<\/td>\n<\/tr>\n \n Molekularformel \/ Gewicht<\/td>\n C55<\/sub>H75<\/sub>N17<\/sub>O13<\/sub> \/ 1182,3 Da<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 638793<\/td>\n<\/tr>\n \n Klasse<\/td>\n Synthetic decapeptide, agonist of the GnRH receptor<\/td>\n<\/tr>\n \n Form<\/td>\n Freeze-dried lyophilisate in vial, supplied as a kit with nasal spray accessories<\/td>\n<\/tr>\n \n Menge pro Einheit<\/td>\n 2 mg<\/td>\n<\/tr>\n \n Lagerung<\/td>\n Store freeze-dried in a cool, dark place; after dissolving, refrigerate at 2\u20138 \u00b0C.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Form, Handhabung und Lagerung<\/h2>\n
Zusammensetzung und Laborergebnisse<\/h2>\n