SNAP-8 (Acetyl Glutamyl Octapeptide-3) er et syntetisk, acetyleret oktapeptid, hvis sekvens er afledt af den N-terminale region af SNAP-25-proteinet, en kernekomponent i SNARE-komplekset. Det tilh\u00f8rer familien af \u200b\u200bacetylerede peptider, der unders\u00f8ges som modelforbindelser i peptid- og kosmetisk kemi. Inden for videnskabelig forskning studeres SNAP-8 i relation til vesikul\u00e6r signalering og stabiliteten af \u200b\u200bkorte syntetiske peptider. Udelukkende beregnet til laboratorie- og forskningsform\u00e5l.<\/p>\n
SNAP-8 er et oktapeptid med aminosyresekvensen Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH\u2082 (forkortet Ac-EEMQRRAD-NH\u2082). Forbindelsen er en udvidet analog af Argirelin (Acetyl Hexapeptide-8, ogs\u00e5 kaldet Acetyl Hexapeptide-3): hvor dette molekyle har seks aminosyrer, tilf\u00f8jer SNAP-8 to ekstra rester (alanin og asparaginsyre) til C-terminalen. N-terminalen b\u00e6rer en acetylgruppe, og C-terminalen en amidgruppe. Begge modifikationer \u00f8ger modstanden mod nedbrydning af amino- og carboxypeptidaser, hvilket g\u00f8r SNAP-8 til en strukturelt stabil model til forskning i korte peptider.<\/p>\n
Forskningsm\u00e6ssig betydning af SNAP-8 stammer fra denne afledte sekvens. Fordi fragmentet efterligner det N-terminale motiv af SNAP-25, bruges det i laboratoriesammenh\u00e6ng som en modelforbindelse til at studere sammens\u00e6tningen af \u200b\u200bSNARE-komplekset - proteinkomplekset, der driver vesikelfusion - og den tilh\u00f8rende frigivelse af signalmolekyler. I denne forstand fungerer SNAP-8 som et defineret, reproducerbart v\u00e6rkt\u00f8j til mekanistisk forskning, ikke som en forbindelse med en anvendelse uden for laboratoriet.<\/p>\n
I laboratoriesammenh\u00e6ng anvendes SNAP-8 blandt andet inden for f\u00f8lgende forskningsomr\u00e5der:<\/p>\n
Within the range of investigational peptides with a dermatological research background, SNAP-8 stands alongside several related molecules that each model a different mechanism. GHK-Cu<\/a> is a copper tripeptide that is classically studied in models involving the extracellular matrix and collagen expression, while Matrixyl<\/a> as a palmitoyl pentapeptide features in collagen and skin research models. Whereas those two focus on matrix and synthesis pathways, SNAP-8 falls within the SNARE and signaling molecule domain, making the molecules complementary in comparative research.<\/p>\n SNAP-8 also appears as a component in a topical research formulation: the GHK-Cu and SNAP-8 Serum 30ml<\/a> combines both peptides for research into concurrent matrix and signaling molecule models. The separate SNAP-8 vial offered here is intended for researchers who wish to reconstitute and characterize the compound separately.<\/p>\nSpecifikationer<\/h2>\n
| Specifikation<\/th>\n | V\u00e6rdi<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Pr\u00f8ve<\/td>\n | SNAP-8 (Acetyl Glutamyl Octapeptide-3)<\/td>\n<\/tr>\n |
| Synonymer<\/td>\n | Acetyl Octapeptide-3 (INCI), Acetyl Octapeptide-1<\/td>\n<\/tr>\n |
| CAS-nummer<\/td>\n | 868844-74-0<\/td>\n<\/tr>\n |
| Molekylformel \/ v\u00e6gt<\/td>\n | C\u2084\u2081H\u2087\u2080N\u2081\u2086O\u2081\u2086S \/ \u00b1 1075.2 Da<\/td>\n<\/tr>\n |
| Sekvens<\/td>\n | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH\u2082 (Ac-EEMQRRAD-NH\u2082)<\/td>\n<\/tr>\n |
| Content \/ form<\/td>\n | 10 mg lyophilized powder (dry powder) per vial<\/td>\n<\/tr>\n |
| Zuiverheid<\/td>\n | \u2265 99% (HPLC)<\/td>\n<\/tr>\n |
| Opbevaring<\/td>\n | Opbevares k\u00f8ligt, beskyttet mod lys og fugt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nForm, h\u00e5ndtering og opbevaring<\/h2>\nSNAP-8 is supplied as a freeze-dried powder (lyophilisate) of 10 mg per vial. In a research context, the lyophilisate is reconstituted with a suitable solvent such as bacteriostatic or sterile water before use; the octapeptide is highly water-soluble. Handle the powder in a cool place and protected from light and moisture, and avoid repeated freeze-thaw cycles to maintain structural integrity.<\/p>\n The dry lyophilisate is most stable when stored in a cool, dark place. After reconstitution, the solution is usually stored refrigerated (2\u20138 \u00b0C) and used within a limited period. Work with clean, calibrated materials and record the concentration and date of reconstitution so that measurements remain reproducible. In research, dosages are expressed in mg of active substance per experiment.<\/p>\n Renhed og laboratorieresultater<\/h2>\nSNAP-8 is offered with a controlled purity of \u2265 99%, determined via HPLC. This degree of purity makes the compound suitable as a defined model compound and reference standard in analytical and preclinical research. Certificates of analysis and lab results of our research compounds can be found bundled on the side med laboratorieresultater<\/a>.<\/p>\n What exactly is SNAP-8?<\/strong> How does SNAP-8 differ from Argireline?<\/strong> In what form is SNAP-8 delivered?<\/strong> How do I store SNAP-8?<\/strong> |