MGF (Mechano Growth Factor) er en splejsningsvariant af insulinlignende v\u00e6kstfaktor 1 (IGF-1), specifikt det C-terminale E-dom\u00e6nepeptid, der opst\u00e5r ved alternativ splejsning af IGF-1-genet. Det er et syntetisk peptid af 24 aminosyrer, ogs\u00e5 omtalt i litteraturen som IGF-1Ec. Inden for videnskabelig forskning studeres det som en modelforbindelse vedr\u00f8rende IGF-1-aksen, mekanotransduktion og cellul\u00e6re reparationsveje. Udelukkende beregnet til laboratorie- og forskningsform\u00e5l.<\/p>\n
MGF st\u00e5r for Mechano Growth Factor og omtales ogs\u00e5 i den videnskabelige litteratur som IGF-1Ec \u2014 \"Ec\"-splejsningsvarianten af \u200b\u200binsulinlignende v\u00e6kstfaktor 1 (et v\u00e6kstfaktorprotein fra insulinfamilien). N\u00e5r IGF-1-genet alternativt splejses under mekaniske eller hypoxiske (iltfattige) forhold, dannes et precursorprotein, hvis C-terminale E-dom\u00e6ne frigives efter enzymatisk spaltning som det 24 aminosyrer store MGF E-peptid; den resterende del danner modent IGF-1. Denne strukturelle lighed placerer MGF inden for den bredere IGF-1-signalfamilie, men med sin egen, kortlivede E-dom\u00e6neprofil, der adskiller den fra det komplette IGF-1-molekyle.<\/p>\n
Som en forbindelse af forskningskvalitet tilbydes MGF som et fryset\u00f8rret pulver (lyofilisat) med en defineret aminosyresekvens. I kontrollerede systemer fungerer det som et strukturelt n\u00f8jagtigt v\u00e6rkt\u00f8j til at modellere dynamikken i IGF-1-aksen, satellitcellebiologi og mekanisk rettet signalering. Inden for videnskabelig forskning studeres det udelukkende som en modelforbindelse uden nogen anvendelse i mennesker eller dyr.<\/p>\n
I laboratoriesammenh\u00e6ng anvendes MGF blandt andet i f\u00f8lgende forskningsomr\u00e5der:<\/p>\n
These applications concern exclusively preclinical, in vitro, or analytical research models and do not describe effects in humans or animals.<\/p>\n
MGF is often studied in research alongside other molecules from the growth hormone-IGF-1 axis. The PEG MGF<\/a>The -variant is a PEGylated form of the same E-domain peptide, in which the polyethylene glycol group in the study serves to compare the conformational stability and degradation rate with the unmodified peptide. IGF-1 LR3<\/a> is a structurally modified IGF-1 analog that is used as the longer reference standard for the IGF-1 axis. Further upstream on the same signal path lie the secretagogues and GHRH analogs: Tesamorelin<\/a> (a synthetic GHRH(1-44) analog) and Ipamorelin<\/a> (a selective agonist of the ghrelin receptor) are being studied as upstream modulators of growth hormone signaling. Together, these compounds form a spectrum that allows researchers to model different levels of the same axis.<\/p>\nSpecifikationer<\/h2>\n
| Specifikation<\/th>\n | V\u00e6rdi<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Pr\u00f8ve<\/td>\n | MGF (Mechano Growth Factor)<\/td>\n<\/tr>\n |
| Synonymer<\/td>\n | IGF-1Ec, MGF E-peptide (IGF-1 splice variant)<\/td>\n<\/tr>\n |
| Sekvens<\/td>\n | YQPPSTNKNTKSQRRKGSTFEERK (24 amino acids)<\/td>\n<\/tr>\n |
| Molekylformel \/ v\u00e6gt<\/td>\n | C\u2081\u2082\u2081H\u2081\u2089\u2089N\u2084\u2081O\u2084\u2080 \/ 2868.1 Da<\/td>\n<\/tr>\n |
| PubChem CID<\/td>\n | 175675731<\/td>\n<\/tr>\n |
| Klasse<\/td>\n | IGF-1 splice variant (E domain peptide)<\/td>\n<\/tr>\n |
| Form<\/td>\n | Lyophilized powder (dry powder) \u2014 2 mg per vial<\/td>\n<\/tr>\n |
| Zuiverheid<\/td>\n | \u2265 99% (HPLC)<\/td>\n<\/tr>\n |
| Opbevaring<\/td>\n | Store refrigerated or at \u221220 \u00b0C, protected from light and moisture.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nForm, h\u00e5ndtering og opbevaring<\/h2>\nMGF is supplied as freeze-dried powder (lyophilized powder) in a 2 mg vial. The lyophilized powder is most stable in its dry form and should be stored refrigerated and protected from light and moisture; for long-term storage, a temperature of \u221220 \u00b0C is maintained. Reconstitution in a laboratory context is typically performed using bacteriostatic water. After reconstitution, the solution is stored refrigerated (2\u20138 \u00b0C) and protected from repeated temperature fluctuations, as short peptides are susceptible to proteolytic degradation. Handle the sample with standard laboratory hygiene and limit unnecessary freeze-thaw cycles to preserve sequence integrity.<\/p>\n Renhed og laboratorieresultater<\/h2>\nMGF is offered with a controlled purity of \u2265 99%, determined by high-performance liquid chromatography (HPLC) \u2014 a standard technique for establishing the identity and homogeneity of synthetic peptides. Certificates of analysis and additional lab results can be found on our website. side med laboratorieresultater<\/a>.<\/p>\n What is the difference between MGF and IGF-1?<\/strong> What is the difference between MGF and PEG MGF?<\/strong> In what form is MGF supplied?<\/strong> How is MGF stored?<\/strong> |