{"id":2983,"date":"2026-09-01T09:42:15","date_gmt":"2026-09-01T09:42:15","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2983"},"modified":"2026-09-02T12:17:52","modified_gmt":"2026-09-02T12:17:52","slug":"peg-mgf-2mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/peg-mgf-2mg\/","title":{"rendered":"PEG MGF 2 mg"},"content":{"rendered":"<p>PEG MGF (PEGylovan\u00fd mechanick\u00fd r\u016fstov\u00fd faktor) je modifikovan\u00e1 peptidov\u00e1 varianta odvozen\u00e1 od IGF-1Ec, sest\u0159ihov\u00e9 izoformy (alternativn\u011b transkribovan\u00e9 genov\u00e9 varianty) inzul\u00ednu podobn\u00e9ho r\u016fstov\u00e9ho faktoru 1 (IGF-1). C-termin\u00e1ln\u00ed 24aminokyselinov\u00fd fragment je kovalentn\u011b v\u00e1z\u00e1n na polyethylenglykol (PEGylace), co\u017e je modifikace, kter\u00e1 zvy\u0161uje molekul\u00e1rn\u00ed stabilitu a dobu cirkulace ve srovn\u00e1n\u00ed s nemodifikovan\u00fdm peptidem. Ve v\u011bdeck\u00e9m v\u00fdzkumu se PEG MGF pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina, pokud jde o sign\u00e1ln\u00ed dr\u00e1hu IGF-1. Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je PEG-MGF?<\/h2>\n<p>Mechano-r\u016fstov\u00fd faktor (MGF) je n\u00e1zev pro sest\u0159ihovou izoformu IGF-1Ec: stejn\u00fd genov\u00fd lokus jako IGF-1, ale s unik\u00e1tn\u00edm 24aminokyselinov\u00fdm C-termin\u00e1ln\u00edm E-peptidem, kter\u00fd je v\u00fdsledkem alternativn\u00edho sest\u0159ihu genu IGF-1. Tento E-peptid je strukturn\u011b odli\u0161n\u00fd od zral\u00e9 molekuly IGF-1 a ve v\u00fdzkumn\u00fdch modelech je pova\u017eov\u00e1n za samostatnou peptidovou sekvenci. V t\u011ble je izoforma exprimov\u00e1na v mechanicky nam\u00e1han\u00e9 nebo po\u0161kozen\u00e9 tk\u00e1ni kostern\u00edho svalstva, co\u017e vysv\u011btluje historick\u00fd n\u00e1zev \u201emechano-r\u016fstov\u00fd faktor\u201c.<\/p>\n<p>Dodatek \u201ePEG\u201c ozna\u010duje PEGylaci: kovalentn\u00ed p\u0159ipojen\u00ed polyethylenglykolov\u00e9ho \u0159et\u011bzce k peptidu. Tato polymern\u00ed frakce zvy\u0161uje efektivn\u00ed molekulovou velikost, zpomaluje enzymatickou degradaci a t\u00edm prodlu\u017euje polo\u010das rozpadu v roztoku. Zat\u00edmco nemodifikovan\u00fd E-peptid se v modelov\u00fdch syst\u00e9mech velmi rychle odbour\u00e1v\u00e1, PEGylovan\u00e1 forma m\u00e1 z\u016fstat m\u011b\u0159iteln\u00e1 po del\u0161\u00ed dobu \u2013 tato vlastnost \u010din\u00ed PEG MGF vhodn\u00fdm jako stabiln\u011bj\u0161\u00ed modelovou slou\u010deninu pro v\u00fdzkum osy IGF-1. PEG MGF nen\u00ed r\u016fstov\u00fd hormon ani zral\u00fd IGF-1; sest\u00e1v\u00e1 v\u00fdhradn\u011b z modifikovan\u00e9ho C-termin\u00e1ln\u00edho fragmentu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>PEG MGF se pou\u017e\u00edv\u00e1 v preklinick\u00fdch a in vitro kontextech jako pom\u016fcka pro studium r\u016fzn\u00fdch ot\u00e1zek. V\u017edy se jedn\u00e1 o to, co je pozorov\u00e1no ve v\u00fdzkumn\u00fdch modelech, nikoli o aplikaci u lid\u00ed nebo zv\u00ed\u0159at:<\/p>\n<ul>\n<li>Sign\u00e1ln\u00ed dr\u00e1ha IGF-1 a role, kterou v n\u00ed hraj\u00ed lok\u00e1ln\u011b exprimovan\u00e9 sest\u0159ihov\u00e9 izoformy krom\u011b syst\u00e9mov\u00e9ho IGF-1.<\/li>\n<li>Mechanotransdukce: jak mechanick\u00e9 zat\u00ed\u017een\u00ed v modelov\u00e9 tk\u00e1ni ovliv\u0148uje alternativn\u00ed sest\u0159ih genu IGF-1.<\/li>\n<li>Satelitn\u00ed bu\u0148ky (svalov\u00e9 kmenov\u00e9 bu\u0148ky): aktivace, vstup do bun\u011b\u010dn\u00e9ho cyklu a proliferace v bun\u011b\u010dn\u00fdch kultur\u00e1ch.<\/li>\n<li>Myogenn\u00ed diferenciace a regenerace tk\u00e1n\u00ed v kontrolovan\u00fdch preklinick\u00fdch podm\u00ednk\u00e1ch.<\/li>\n<li>Farmakokinetika PEGylace: vliv PEG frakce na polo\u010das rozpadu, rozpustnost a clearance.<\/li>\n<li>Anal\u00fdza struktury a aktivity: rozd\u00edl mezi izolovan\u00fdm E-peptidem a kompletn\u00ed molekulou IGF-1.<\/li>\n<\/ul>\n<h2>PEG MGF ve srovn\u00e1n\u00ed s p\u0159\u00edbuzn\u00fdmi slou\u010deninami<\/h2>\n<p>PEG MGF pat\u0159\u00ed do \u0161ir\u0161\u00ed v\u00fdzkumn\u00e9 skupiny zahrnuj\u00edc\u00ed osy r\u016fstov\u00e9ho hormonu a IGF-1. Nejp\u0159\u00edmo souvisej\u00edc\u00edm produktem je nemodifikovan\u00fd <a href=\"https:\/\/lumopeptides.com\/product\/mgf\/\" target=\"_blank\" rel=\"noopener\">MGF 2 mg<\/a>: stejn\u00e1 sekvence E-peptidu, ale bez PEGylace, a proto s krat\u0161\u00edm polo\u010dasem rozpadu modelu. Pro v\u00fdzkum samotn\u00e9 molekuly IGF-1, <a href=\"https:\/\/lumopeptides.com\/product\/igf-1-lr3\/\" target=\"_blank\" rel=\"noopener\">IGF-1 LR3 1 mg<\/a> \u0161iroce pou\u017e\u00edvan\u00fd analog s prodlou\u017eenou stabilitou. Zat\u00edmco varianty MGF p\u0159edstavuj\u00ed downstream fragment osy, sekretagogy a analogy GHRH funguj\u00ed jako <a href=\"https:\/\/lumopeptides.com\/product\/tesamorelin\/\" target=\"_blank\" rel=\"noopener\">Tesamorelin<\/a> p\u0159esn\u011bji d\u00e1le proti proudu ve stejn\u00e9 sign\u00e1ln\u00ed kask\u00e1d\u011b. Tato spojen\u00ed dohromady umo\u017e\u0148uj\u00ed porovn\u00e1vat r\u016fzn\u00e9 \u00farovn\u011b osy IGF-1 v modelov\u00e9m v\u00fdzkumu.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>PEG MGF (PEGylovan\u00fd mechanick\u00fd r\u016fstov\u00fd faktor)<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>PEG-MGF, pegylovan\u00fd MGF, pegylovan\u00fd IGF-1Ec<\/td>\n<\/tr>\n<tr>\n<td>Struktura<\/td>\n<td>C-termin\u00e1ln\u00ed 24aminokyselinov\u00fd E-peptid IGF-1Ec (sest\u0159ihov\u00e1 izoforma IGF-1)<\/td>\n<\/tr>\n<tr>\n<td>Z\u00e1kladn\u00ed sekvence (MGF)<\/td>\n<td>YQPPSTNKNTKSQRRKGSTFEEHK (24 aminokyselin)<\/td>\n<\/tr>\n<tr>\n<td>Modifikace<\/td>\n<td>Kovalentn\u011b v\u00e1zan\u00fd polyethylenglykol (PEGylace)<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t), 2 mg na lahvi\u010dku<\/td>\n<\/tr>\n<tr>\n<td>\u010cistota<\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Lyofilizov\u00e1no v chladu a tm\u011b; po rekonstituci uchov\u00e1vejte v chladni\u010dce<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Molekulovou hmotnost PEG MGF nelze uv\u00e9st jako jednu pevnou hodnotu: z\u00e1kladn\u00ed E-peptid m\u00e1 p\u0159ibli\u017en\u011b 2,9 kDa, zat\u00edmco p\u0159ipojen\u00e1 frakce PEG v\u00fdznamn\u011b zvy\u0161uje celkovou hmotnost v z\u00e1vislosti na d\u00e9lce \u0159et\u011bzce. Jednotn\u00e9 \u010d\u00edslo CAS nebo PubChem CID pro PEGylovanou formu nebylo jednozna\u010dn\u011b stanoveno; tato pravidla byla proto z d\u016fvodu spravedliv\u00e9 definice v tabulce vynech\u00e1na.<\/p>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>PEG MGF se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek v 2mg lahvi\u010dce. P\u0159ed pou\u017eit\u00edm ve v\u00fdzkumu se lyofiliz\u00e1t rekonstituuje vhodn\u00fdm rozpou\u0161t\u011bdlem, obvykle bakteriostatickou vodou, kter\u00e1 se p\u0159id\u00e1v\u00e1 pod\u00e9l st\u011bny lahvi\u010dky, ani\u017e by se obsah p\u0159\u00edmo rozst\u0159ikoval. Lahvi\u010dka se pot\u00e9 jemn\u011b ot\u00e1\u010d\u00ed, nikoli prot\u0159ep\u00e1v\u00e1, aby se peptid zcela rozpustil bez mechanick\u00e9ho nam\u00e1h\u00e1n\u00ed. Neotev\u0159en\u00fd lyofiliz\u00e1t skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b; po rekonstituci by m\u011bl b\u00fdt roztok skladov\u00e1n v chladni\u010dce a m\u011blo by se vyhnout opakovan\u00fdm cykl\u016fm zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed, aby se omezila degradace. Pracujte v \u010dist\u00e9m, kontrolovan\u00e9m v\u00fdzkumn\u00e9m prost\u0159ed\u00ed a zaznamenejte datum rekonstituce a koncentraci pro experiment\u00e1ln\u00ed reprodukovatelnost.<\/p>\n<h2>\u010cistota a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>PEG MGF je nab\u00edzen s kontrolovanou \u010distotou \u2265 99 %, stanovenou pomoc\u00ed HPLC anal\u00fdzy. \u010cistota a identita jsou d\u016fle\u017eit\u00e9, proto\u017ee kontaminanty nebo produkty degradace mohou zkreslit interpretaci modelov\u00e9ho v\u00fdzkumu. P\u0159ehled dostupn\u00fdch anal\u00fdz a certifik\u00e1t\u016f naleznete na na\u0161ich webov\u00fdch str\u00e1nk\u00e1ch. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<p class=\"lumo-blogcta\"><strong>Chcete se dozv\u011bd\u011bt v\u00edce?<\/strong> P\u0159e\u010dt\u011bte si na\u0161eho pr\u016fvodce: <a href=\"https:\/\/lumopeptides.com\/hgh-peptiden-ghrh-ghrp-uitgelegd\/\" target=\"_blank\" rel=\"noopener\">Vysv\u011btlen\u00ed peptid\u016f HGH: analogy GHRH, GHRP a rozd\u00edl od skute\u010dn\u00e9ho r\u016fstov\u00e9ho hormonu<\/a>.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Co znamen\u00e1 \u201ePEG\u201c v PEG MGF?<\/strong><br \/>PEG je zkratka pro polyethylenglykol. Kovalentn\u00edm nav\u00e1z\u00e1n\u00edm tohoto polymeru na peptid MGF (PEGylace) se zvy\u0161uje molekul\u00e1rn\u00ed stabilita a degradace prob\u00edh\u00e1 pomaleji, co\u017e umo\u017e\u0148uje, aby slou\u010denina z\u016fstala m\u011b\u0159iteln\u00e1 v modelov\u00fdch syst\u00e9mech po del\u0161\u00ed dobu.<\/p>\n<p><strong>Jak\u00fd je rozd\u00edl mezi PEG MGF a b\u011b\u017en\u00fdm MGF?<\/strong><br \/>Oba sd\u00edlej\u00ed stejnou 24aminokyselinovou E-peptidovou sekvenci IGF-1Ec. PEG MGF nav\u00edc nese PEG \u0159et\u011bzec, kter\u00fd prodlu\u017euje polo\u010das rozpadu; nemodifikovan\u00fd <a href=\"https:\/\/lumopeptides.com\/product\/mgf\/\" target=\"_blank\" rel=\"noopener\">MGF 2 mg<\/a> tuto \u00fapravu postr\u00e1d\u00e1 a v modelech se vyma\u017ee rychleji.<\/p>\n<p><strong>Je PEG MGF tot\u00e9\u017e co IGF-1?<\/strong><br \/>Ne. PEG MGF se skl\u00e1d\u00e1 v\u00fdhradn\u011b z C-termin\u00e1ln\u00edho E-peptidu sest\u0159ihov\u00e9 izoformy IGF-1Ec, nikoli ze zral\u00e9 molekuly IGF-1. Jedn\u00e1 se o strukturn\u011b odli\u0161n\u00fd fragment v r\u00e1mci stejn\u00e9 sign\u00e1ln\u00ed dr\u00e1hy.<\/p>\n<p><strong>V jak\u00e9m kontextu se pou\u017e\u00edv\u00e1 PEG MGF?<\/strong><br \/>V\u00fdhradn\u011b ve v\u011bdeck\u00e9m laboratorn\u00edm a v\u00fdzkumn\u00e9m prost\u0159ed\u00ed, jako modelov\u00e1 slou\u010denina pro studium sign\u00e1ln\u00ed dr\u00e1hy IGF-1, sest\u0159ihov\u00fdch izoforem a vlivu PEGylace na farmakokinetiku peptid\u016f.<\/p>\n<p><strong>Jak m\u00e1m skladovat PEG MGF?<\/strong><br \/>Lyofilizovan\u00fd pr\u00e1\u0161ek se skladuje na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b. Po rekonstituci se roztok skladuje v chladni\u010dce a pro zachov\u00e1n\u00ed integrity peptidu se vyh\u00fdb\u00e1 opakovan\u00fdm cykl\u016fm zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed.<\/p>\n<p><em>Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010deno k lidsk\u00e9 ani zv\u00ed\u0159ec\u00ed spot\u0159eb\u011b, ani k l\u00e9ka\u0159sk\u00e9mu, diagnostick\u00e9mu, terapeutick\u00e9mu nebo kosmetick\u00e9mu pou\u017eit\u00ed. Kupuj\u00edc\u00ed je star\u0161\u00ed 18 let a potvrzuje kontext v\u00fdzkumu. Nejedn\u00e1 se o l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p><strong>PEG-MGF<\/strong> je PEGylovan\u00e1 varianta mechanick\u00e9ho r\u016fstov\u00e9ho faktoru, sest\u0159ihov\u00e9 izoformy IGF-1 (IGF-1Ec). C-termin\u00e1ln\u00ed fragment je kovalentn\u011b v\u00e1z\u00e1n na polyethylenglykol (PEGylace), dod\u00e1van\u00fd jako lyofiliz\u00e1t.<\/p>\n<p><em>Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nen\u00ed ur\u010deno k lidsk\u00e9 ani zv\u00ed\u0159ec\u00ed spot\u0159eb\u011b. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek ani dopln\u011bk stravy.<\/em><\/p>","protected":false},"featured_media":3257,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[124,121],"product_tag":[],"class_list":["post-2983","product","type-product","status-publish","has-post-thumbnail","product_cat-musculoskeletaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2983"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2983\/revisions"}],"predecessor-version":[{"id":3048,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2983\/revisions\/3048"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3257"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2983"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2983"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2983"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}