{"id":2947,"date":"2026-09-01T09:38:54","date_gmt":"2026-09-01T09:38:54","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2947"},"modified":"2026-09-02T12:17:48","modified_gmt":"2026-09-02T12:17:48","slug":"sermorelin-acetaat-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/sermorelin-acetaat-10mg\/","title":{"rendered":"Sermorelin acet\u00e1t 10 mg"},"content":{"rendered":"<p>Sermorelin acet\u00e1t je syntetick\u00fd polypeptid t\u0159\u00eddy analog\u016f GHRH, chemicky acet\u00e1tov\u00e1 s\u016fl \u0159et\u011bzce 29 aminokyselin s C-termin\u00e1ln\u00ed amidovou funkc\u00ed. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro farmakologii receptor\u016f sp\u0159a\u017een\u00fdch s G-proteinem t\u0159\u00eddy B a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je sermorelin acet\u00e1t?<\/h2>\n<p>Sermorelin (hGHRH(1-29)NH)<sub>2<\/sub>) odpov\u00edd\u00e1 N-termin\u00e1ln\u00edmu fragmentu prvn\u00edch 29 aminokyselin lidsk\u00e9ho r\u016fstov\u00e9ho hormonu uvol\u0148uj\u00edc\u00edho hormon, endogenn\u00edho polypeptidu o 44 aminokyselinov\u00fdch aminokyselin\u00e1ch. Sekvence m\u00e1 tvar Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH<sub>2<\/sub>V literatu\u0159e je tento fragment pova\u017eov\u00e1n za nejkrat\u0161\u00ed \u010d\u00e1st, kter\u00e1 si zachov\u00e1v\u00e1 pln\u00e9 rozpozn\u00e1v\u00e1n\u00ed receptorem; \u0159et\u011bzec se skl\u00e1d\u00e1 do amfipatick\u00e9 alfa-\u0161roubovice, jej\u00ed\u017e hydrofobn\u00ed strana tvo\u0159\u00ed kontaktn\u00ed povrch. Tato kombinace kr\u00e1tk\u00e9 sekvence a intaktn\u00edho vazebn\u00e9ho profilu \u010din\u00ed ze slou\u010deniny \u0161iroce pou\u017e\u00edvan\u00fd strukturn\u00ed model. Acet\u00e1t p\u016fsob\u00ed jako protiiont.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech se Sermorelin v\u00e1\u017ee na receptor GHRH (GHRHR), co\u017e je receptor sp\u0159a\u017een\u00fd s G-proteinem t\u0159\u00eddy B. V bun\u011b\u010dn\u00fdch modelech se tento receptor v\u00e1\u017ee prost\u0159ednictv\u00edm G1.<sub>s<\/sub> na adenyl\u00e1tcykl\u00e1zu, kter\u00e1 in vitro vede k tvorb\u011b cAMP a aktivaci proteinkin\u00e1zy A; tato kask\u00e1da je standardn\u00edm m\u011b\u0159\u00edtkem v receptorov\u00fdch testech. Krom\u011b toho je tato slou\u010denina klasick\u00fdm substr\u00e1tem pro enzymatickou pr\u00e1ci: dipeptidylpeptid\u00e1za-4 \u0161t\u011bp\u00ed N-termin\u00e1ln\u00ed dipeptid in vitro, na\u010de\u017e zb\u00fdvaj\u00edc\u00ed fragment vykazuje v\u00fdznamn\u011b sn\u00ed\u017eenou afinitu k receptoru. Sermorelin acet\u00e1t se proto pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se sermorelin acet\u00e1t vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>V\u00fdzkum receptor\u016f GHRH, v\u010detn\u011b vazebn\u00fdch studi\u00ed na izolovan\u00fdch bun\u011b\u010dn\u00fdch modelech in vitro.<\/li>\n<li>Studie sign\u00e1ln\u00ed transdukce do G<sub>s<\/sub>aktivace v\u00e1zan\u00e9 adenyl\u00e1tcykl\u00e1zy a tvorba cAMP v bun\u011b\u010dn\u00fdch kultiva\u010dn\u00edch syst\u00e9mech.<\/li>\n<li>Enzymologick\u00e9 vy\u0161et\u0159en\u00ed dipeptidylpeptid\u00e1zy-4 a \u0161t\u011bpen\u00ed N-termin\u00e1ln\u00edho dipeptidu in vitro.<\/li>\n<li>Studie vztahu struktury a aktivity C-termin\u00e1ln\u00ed amidov\u00e9 funkce a jednotliv\u00fdch zbytk\u016f v amfipatick\u00e9 helixu.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS) s pou\u017eit\u00edm sermorelin acet\u00e1tu jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a rozpustnosti lyofilizovan\u00fdch polypeptid\u016f za kontrolovan\u00fdch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Sermorelin acet\u00e1t v na\u0161em v\u00fdzkumn\u00e9m sortimentu<\/h2>\n<p>Sermorelin acet\u00e1t spad\u00e1 v na\u0161\u00ed produktov\u00e9 \u0159ad\u011b do kategorie lyofilizovan\u00fdch peptid\u016f ve form\u011b lahvi\u010dek. V\u00fdzkumn\u00edci pravideln\u011b kombinuj\u00ed tuto slou\u010deninu s jin\u00fdmi polypeptidy, kter\u00e9 jsou studov\u00e1ny prost\u0159ednictv\u00edm jejich vlastn\u00edho biochemick\u00e9ho c\u00edle. Zat\u00edmco Sermorelin acet\u00e1t c\u00edl\u00ed na receptor sp\u0159a\u017een\u00fd s G-proteinem t\u0159\u00eddy B a souvisej\u00edc\u00ed kask\u00e1du cAMP, byly v r\u00e1mci stejn\u00e9 produktov\u00e9 \u0159ady vybr\u00e1ny i jin\u00e9 slo\u017eky, kter\u00e9 pokr\u00fdvaj\u00ed odli\u0161n\u00e9 receptorov\u00e9 rodiny nebo enzymatick\u00e9 dr\u00e1hy. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale li\u0161\u00ed se slo\u017een\u00edm aminokyselin a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>Sermorelin acet\u00e1t<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>hGHRH(1-29)NH<sub>2<\/sub>GRF(1-29)NH<sub>2<\/sub>Somatotropin uvol\u0148uj\u00edc\u00ed hormon (1-29)amid<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>86168-78-7<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>149<\/sub>H<sub>246<\/sub>N<sub>44<\/sub>O<sub>42<\/sub>S \/ 3357,9 Da (voln\u00e1 b\u00e1ze)<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>16132413<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Syntetick\u00fd polypeptid, 29 aminokyselin, analog GHRH<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ek) v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Lyofilizovan\u00e9 skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Sermorelin acet\u00e1t se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg na lahvi\u010dku. Lyofiliz\u00e1t je b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd pr\u00e1\u0161ek na dn\u011b lahvi\u010dky. Na rozd\u00edl od pevn\u00fdch tablet je materi\u00e1l v lyofilizovan\u00e9m stavu ur\u010den k rozpu\u0161t\u011bn\u00ed ve vhodn\u00e9m rozpou\u0161t\u011bdle v laboratorn\u00edm za\u0159\u00edzen\u00ed p\u0159ed proveden\u00edm analytick\u00e9 pr\u00e1ce.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed, v p\u016fvodn\u00edm obalu. S p\u0159ipojen\u00edm manipulujte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly. Omezte kol\u00eds\u00e1n\u00ed teploty. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>U tohoto lyofiliz\u00e1tu je zachov\u00e1na kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC). Lahvi\u010dka obsahuje polypeptid ve form\u011b acet\u00e1tov\u00e9 soli bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy se shroma\u017e\u010fuj\u00ed centr\u00e1ln\u011b tam, abyste mohli data za\u010dlenit do vlastn\u00edch v\u00fdzkumn\u00fdch z\u00e1znam\u016f.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed Sermorelin acet\u00e1t?<\/strong><br \/>Sermorelin acet\u00e1t je syntetick\u00fd polypeptid o 29 aminokyselin\u00e1ch s C-termin\u00e1ln\u00ed amidovou funkc\u00ed, klasifikovan\u00fd jako analog GHRH. Nejedn\u00e1 se o malou syntetickou molekulu, ale o peptid s definovanou aminokyselinovou sekvenc\u00ed.<\/p>\n<p><strong>Pro\u010d je dipeptidylpeptid\u00e1za-4 relevantn\u00ed ve v\u00fdzkumu s touto slou\u010deninou?<\/strong><br \/>Ve v\u00fdzkumn\u00fdch modelech tento enzym \u0161t\u011bp\u00ed N-termin\u00e1ln\u00ed dipeptid z \u0159et\u011bzce. V\u00fdsledn\u00fd fragment vykazuje in vitro v\u00fdznamn\u011b sn\u00ed\u017eenou afinitu k receptoru, co\u017e z t\u00e9to slou\u010deniny \u010din\u00ed \u0161iroce pou\u017e\u00edvan\u00fd referen\u010dn\u00ed bod v enzymologick\u00e9m v\u00fdzkumu.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg v uzav\u0159en\u00e9 lahvi\u010dce, ur\u010den\u00fd k rozpu\u0161t\u011bn\u00ed ve vhodn\u00e9m rozpou\u0161t\u011bdle v laboratorn\u00edm za\u0159\u00edzen\u00ed.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladu a tm\u011b, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe v p\u016fvodn\u00edm obalu.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"696\" data-end=\"748\">Sermorelin \u2013 peptid pro v\u00fdzkumn\u00e9 aplikace<\/strong><br data-start=\"748\" data-end=\"751\" \/>Sermorelin je syntetick\u00fd peptid zalo\u017een\u00fd na fragmentu p\u0159irozen\u011b se vyskytuj\u00edc\u00ed molekuly hormonu. Pou\u017e\u00edv\u00e1 se v laboratorn\u00edch a preklinick\u00fdch v\u00fdzkumn\u00fdch modelech, ve kter\u00fdch se studuj\u00ed vlastnosti peptid\u016f, molekul\u00e1rn\u00ed struktury a interakce receptor\u016f. Sermorelin nen\u00ed l\u00e9ka\u0159sk\u00fd, farmaceutick\u00fd ani spot\u0159ebn\u00ed produkt.<\/p>","protected":false},"featured_media":3256,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[124,121],"product_tag":[],"class_list":["post-2947","product","type-product","status-publish","has-post-thumbnail","product_cat-musculoskeletaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2947"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2947\/revisions"}],"predecessor-version":[{"id":3019,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2947\/revisions\/3019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3256"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2947"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2947"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2947"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}