{"id":2900,"date":"2026-09-01T09:35:05","date_gmt":"2026-09-01T09:35:05","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2900"},"modified":"2026-09-02T12:15:40","modified_gmt":"2026-09-02T12:15:40","slug":"ara-290-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/ara-290-vial-10-mg\/","title":{"rendered":"Ara-290 injek\u010dn\u00ed lahvi\u010dka 10 mg"},"content":{"rendered":"<p>Ara-290 je syntetick\u00fd v\u00fdzkumn\u00fd peptid, chemicky line\u00e1rn\u00ed undekapeptid odvozen\u00fd z B-helixov\u00e9 dom\u00e9ny erytropoetinu. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro receptorovou a cytokinovou signalizaci a jako referen\u010dn\u00ed standard v analytick\u00e9 pr\u00e1ci. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je Ara-290?<\/h2>\n<p>Ara-290 (L-pyroglutamyl-L-glutamyl-L-glutaminyl-L-leucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serin) je line\u00e1rn\u00ed peptid o jeden\u00e1cti aminokyselin\u00e1ch se sekvenc\u00ed Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. \u0158et\u011bzec je modelov\u00e1n podle vn\u011bj\u0161\u00edho povrchu \u03b2-helixu erytropoetinu, co\u017e t\u00e9to slou\u010denin\u011b v literatu\u0159e vyneslo ozna\u010den\u00ed pyroglutam\u00e1t-helix-\u03b2-povrchov\u00fd-peptid (pHBSP). N-termin\u00e1ln\u00ed pyroglutam\u00e1t ukon\u010duje aminoskupinu \u0159et\u011bzce, co\u017e je strukturn\u00ed prvek, d\u00edky kter\u00e9mu je peptid m\u00e9n\u011b n\u00e1chyln\u00fd k degradaci aminopeptid\u00e1zami in vitro. D\u00edky tomu je Ara-290 u\u017eite\u010dn\u00fdm modelem p\u0159i studiu rozpozn\u00e1v\u00e1n\u00ed peptidov\u00fdch receptor\u016f.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech se Ara-290 nev\u00e1\u017ee na klasick\u00fd homodimern\u00ed erytropoetinov\u00fd receptor, ale selektivn\u011b na heteromern\u00ed receptorov\u00fd komplex slo\u017een\u00fd z EPO receptoru (EPOR) a spole\u010dn\u00e9ho beta \u0159et\u011bzce CD131 (\u03b2cR). Tento komplex se ve v\u011bdeck\u00e9 literatu\u0159e ozna\u010duje jako vrozen\u00fd repara\u010dn\u00ed receptor (IRR). V d\u016fsledku toho lze peptid v bun\u011b\u010dn\u00fdch modelech pou\u017e\u00edt ke studiu obou sign\u00e1ln\u00edch drah samostatn\u011b. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu se proto Ara-290 pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se Ara-290 vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>V\u00fdzkum receptor\u016f heteromeru EPOR\/CD131 a jeho srovn\u00e1n\u00ed s homodimern\u00edm EPO receptorem v kultivovan\u00fdch bun\u011b\u010dn\u00fdch lini\u00edch.<\/li>\n<li>V\u00fdzkum intracelul\u00e1rn\u00ed sign\u00e1ln\u00ed transdukce (v\u010detn\u011b drah JAK2\/STAT a PI3K\/Akt) po vazb\u011b na receptor in vitro.<\/li>\n<li>Studie vztahu struktury a aktivity, ve kter\u00e9 se m\u011bn\u00ed jednotliv\u00e9 pozice aminokyselin undekapeptidu.<\/li>\n<li>Biofyzik\u00e1ln\u00ed modelov\u00e9 studie peptidov\u00fdch fragment\u016f, kter\u00e9 napodobuj\u00ed spir\u00e1lov\u00fd povrch v\u011bt\u0161\u00edho proteinu.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS) s pou\u017eit\u00edm Ara-290 jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a rozpustnosti kr\u00e1tk\u00fdch line\u00e1rn\u00edch peptid\u016f s blokovan\u00fdm N-koncem za kontrolovan\u00fdch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Ara-290 v na\u0161\u00ed v\u00fdzkumn\u00e9 \u0159ad\u011b<\/h2>\n<p>V na\u0161\u00ed nab\u00eddce spad\u00e1 Ara-290 do kategorie lyofilizovan\u00fdch v\u00fdzkumn\u00fdch peptid\u016f ve form\u011b lahvi\u010dek. V\u00fdzkumn\u00edci tuto slou\u010deninu pravideln\u011b kombinuj\u00ed s jin\u00fdmi peptidy, kter\u00e9 jsou studov\u00e1ny prost\u0159ednictv\u00edm jejich vlastn\u00edho biochemick\u00e9ho c\u00edle. Zat\u00edmco Ara-290 c\u00edl\u00ed na heteromern\u00ed receptorov\u00fd komplex z rodiny cytokinov\u00fdch receptor\u016f, jin\u00e9 slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly vybr\u00e1ny tak, aby pokr\u00fdvaly odli\u0161n\u00e9 rodiny receptor\u016f nebo strukturn\u00ed motivy. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed v aminokyselinov\u00e9 sekvenci, molekul\u00e1rn\u00ed velikosti a zkouman\u00e9m mechanismu.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>Ara-290<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>Cibinetid; povrchov\u00fd peptid pyroglutam\u00e1tov\u00e9 helixy B (pHBSP); ARA290<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>1208243-50-8<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>51<\/sub>H<sub>84<\/sub>N<sub>16<\/sub>O<sub>21<\/sub> \/ 1257,3 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>91810664<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Syntetick\u00fd line\u00e1rn\u00ed peptid (undekapeptid), odvozen\u00fd z povrchu \u03b2-helixu erytropoetinu<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Lyofilizovan\u00e9 skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b; pro del\u0161\u00ed skladov\u00e1n\u00ed p\u0159i teplot\u011b -20 \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Ara-290 se dod\u00e1v\u00e1 jako lyofilizovan\u00fd b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd pr\u00e1\u0161ek se standardizovan\u00fdm mno\u017estv\u00edm 10 mg na lahvi\u010dku. Na rozd\u00edl od pevn\u00e9 tablety se jedn\u00e1 o lyofiliz\u00e1t: p\u0159ed analytickou prac\u00ed se materi\u00e1l rozpust\u00ed v z\u00e1vislosti na protokolu laborato\u0159e. Lyofilizovan\u00fd pr\u00e1\u0161ek je hygroskopick\u00fd a m\u011bl by b\u00fdt co nejkrat\u0161\u00ed dobu vystaven okoln\u00edmu vzduchu.<\/p>\n<p>Neotev\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a such\u00e9m m\u00edst\u011b chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem v p\u016fvodn\u00edm obalu; pro del\u0161\u00ed skladov\u00e1n\u00ed je obvykl\u00e9 mrazen\u00ed p\u0159i teplot\u011b -20 \u00b0C. Dodr\u017eujte obvykl\u00e1 laboratorn\u00ed opat\u0159en\u00ed: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>U tohoto lyofiliz\u00e1tu je zachov\u00e1na kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC). Uveden\u00e9 mno\u017estv\u00ed 10 mg se vztahuje k samotn\u00e9mu peptidu bez p\u0159idan\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tek.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy se shroma\u017e\u010fuj\u00ed centr\u00e1ln\u011b tam, abyste mohli data za\u010dlenit do vlastn\u00edch v\u00fdzkumn\u00fdch z\u00e1znam\u016f.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do jak\u00e9 t\u0159\u00eddy prachu pat\u0159\u00ed Ara-290?<\/strong><br \/>Ara-290 je syntetick\u00fd line\u00e1rn\u00ed peptid o jeden\u00e1cti aminokyselin\u00e1ch (undekapeptid) se sekvenc\u00ed Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. Nejedn\u00e1 se o malou organickou molekulu, ale o peptidov\u00fd fragment, kter\u00fd napodobuje povrch glykoproteinu erytropoetinu.<\/p>\n<p><strong>Co se ve v\u00fdzkumu rozum\u00ed pod pojmem vrozen\u00fd repara\u010dn\u00ed receptor?<\/strong><br \/>V literatu\u0159e se t\u00edm ozna\u010duje heteromern\u00ed receptorov\u00fd komplex EPO receptoru (EPOR) a spole\u010dn\u00e9ho beta \u0159et\u011bzce CD131. V bun\u011b\u010dn\u00fdch modelech Ara-290 c\u00edl\u00ed na tento komplex a nikoli na homodimern\u00ed EPO receptor, co\u017e umo\u017e\u0148uje rozli\u0161it ob\u011b sign\u00e1ln\u00ed dr\u00e1hy in vitro.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek v lahvi\u010dce obsahuj\u00edc\u00ed 10 mg peptidu. Lyofiliz\u00e1t se p\u0159ed analytick\u00fdm pou\u017eit\u00edm rozpust\u00ed.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Lyofilizov\u00e1no, v chladu, suchu a chr\u00e1n\u011bno p\u0159ed sv\u011btlem v p\u016fvodn\u00edm obalu; pro del\u0161\u00ed skladov\u00e1n\u00ed p\u0159i teplot\u011b -20 \u00b0C.<\/p>","protected":false},"excerpt":{"rendered":"<p data-start=\"743\" data-end=\"1147\"><strong data-start=\"743\" data-end=\"792\">ARA-290 \u2013 Peptid pro v\u00fdzkumn\u00e9 aplikace<\/strong><br data-start=\"792\" data-end=\"795\" \/>ARA-290 je syntetick\u00fd peptid o 11 aminokyselin\u00e1ch, zalo\u017een\u00fd na specifick\u00e9 strukturn\u00ed dom\u00e9n\u011b p\u0159irozen\u011b se vyskytuj\u00edc\u00edho proteinu. Pou\u017e\u00edv\u00e1 se v laboratorn\u00edch a preklinick\u00fdch v\u00fdzkumn\u00fdch prost\u0159ed\u00edch pro studium peptidov\u00fdch vlastnost\u00ed, interakc\u00ed receptor\u016f a molekul\u00e1rn\u00ed stability. ARA-290 nen\u00ed spot\u0159ebitelsk\u00fd ani l\u00e9ka\u0159sk\u00fd produkt.<\/p>\n<h3 data-start=\"1149\" data-end=\"1176\"><\/h3>","protected":false},"featured_media":3241,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[125,121],"product_tag":[],"class_list":["post-2900","product","type-product","status-publish","has-post-thumbnail","product_cat-herstel-reparatie","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2900"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2900\/revisions"}],"predecessor-version":[{"id":2978,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2900\/revisions\/2978"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3241"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2900"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2900"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2900"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}