{"id":2877,"date":"2026-09-01T09:33:40","date_gmt":"2026-09-01T09:33:40","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2877"},"modified":"2026-09-02T12:24:07","modified_gmt":"2026-09-02T12:24:07","slug":"ghk-cu","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/ghk-cu\/","title":{"rendered":"GHK-CU"},"content":{"rendered":"<p>GHK-Cu je tripeptidov\u00fd komplex v\u00e1zaj\u00edc\u00ed m\u011b\u010f, chemicky metalopeptid glycyl-L-histidyl-L-lysinu s koordinovan\u00fdm iontem m\u011bdi(II). Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro koordina\u010dn\u00ed chemii komplex\u016f peptid-kov a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je GHK-Cu?<\/h2>\n<p>GHK-Cu je m\u011b\u010fnat\u00fd(II) komplex p\u0159irozen\u011b se vyskytuj\u00edc\u00edho tripeptidu GHK s aminokyselinovou sekvenc\u00ed glycin-histidin-lysin (Gly-His-Lys). Kovov\u00fd iont nen\u00ed voln\u011b asociov\u00e1n, ale je fixov\u00e1n v definovan\u00e9 koordina\u010dn\u00ed kapse: vazebn\u00fd re\u017eim je typicky popisov\u00e1n jako plan\u00e1rn\u00ed uspo\u0159\u00e1d\u00e1n\u00ed t\u0159\u00ed donor\u016f dus\u00edku, a to \u03b1-aminoskupiny N-termin\u00e1ln\u00edho glycinu, deprotonovan\u00e9ho amidov\u00e9ho atomu dus\u00edku prvn\u00ed peptidov\u00e9 vazby a imidazolu histidinu. Bazick\u00fd lysinov\u00fd postrann\u00ed \u0159et\u011bzec z\u016fst\u00e1v\u00e1 mimo toto uspo\u0159\u00e1d\u00e1n\u00ed a udr\u017euje komplex vysoce rozpustn\u00fd ve vod\u011b. Vzhledem k tomu, \u017ee tato geometrie je tak ost\u0159e definovan\u00e1, je GHK-Cu pova\u017eov\u00e1n za klasick\u00fd modelov\u00fd syst\u00e9m pro vazbu m\u011bdi na kr\u00e1tk\u00e9 peptidy v bioanorganick\u00e9 chemii.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech je komplex prim\u00e1rn\u011b studov\u00e1n jako vym\u011bniteln\u00fd rezervo\u00e1r m\u011bdi: in vitro m\u016f\u017ee b\u00fdt koordinovan\u00fd iont za definovan\u00fdch podm\u00ednek p\u0159enesen na konkuren\u010dn\u00ed ligandy nebo na m\u011b\u010f-dependentn\u00ed enzymy, jako je lysyloxid\u00e1za a superoxiddismut\u00e1za, s nimi\u017e se vazebn\u00e9 konstanty a rychlosti v\u00fdm\u011bny st\u00e1vaj\u00ed srovnateln\u00fdmi. M\u011b\u010fnat\u00e9 centrum nav\u00edc usnad\u0148uje spektroskopick\u00e9 sledov\u00e1n\u00ed komplexu: vedle UV absorpce imidazolu doch\u00e1z\u00ed ve viditeln\u00e9 oblasti ke slab\u00e9mu p\u0159echodu dd, co\u017e vysv\u011btluje charakteristickou modrou barvu a umo\u017e\u0148uje m\u011b\u0159en\u00ed tvorby nebo rozkladu komplexu. V d\u016fsledku toho se GHK-Cu pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm prost\u0159ed\u00ed se GHK-Cu vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Bioanorganick\u00e1 koordina\u010dn\u00ed chemie: konstanty stability, stechiometrie a geometrie komplex\u016f m\u011b\u010f(II)-peptid.<\/li>\n<li>Enzymologick\u00fd v\u00fdzkum enzym\u016f z\u00e1visl\u00fdch na m\u011bdi, v\u010detn\u011b lysyloxid\u00e1zy a superoxiddismut\u00e1zy, v bezbun\u011b\u010dn\u00fdch syst\u00e9mech.<\/li>\n<li>Studie vztahu struktury a aktivity tripeptid\u016f s histidinem v poloze 2 a jejich afinita k m\u011bdi.<\/li>\n<li>Modely bun\u011b\u010dn\u00fdch kultur pro p\u0159em\u011bnu slo\u017eek extracelul\u00e1rn\u00ed matrix na fibroblastov\u00e9 kultury.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, UV-vis, LC-MS) s GHK-Cu jako referen\u010dn\u00edm standardem.<\/li>\n<li>Studie stability metalopeptid\u016f za kontrolovan\u00fdch sv\u011bteln\u00fdch, pH a oxida\u010dn\u00edch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>GHK-Cu v na\u0161em v\u00fdzkumn\u00e9m sortimentu<\/h2>\n<p>V na\u0161\u00ed nab\u00eddce spad\u00e1 GHK-Cu do kategorie lyofilizovan\u00fdch v\u00fdzkumn\u00fdch slou\u010denin ve form\u011b lahvi\u010dek, co\u017e je kategorie, kterou v\u011bdci pravideln\u011b kombinuj\u00ed s l\u00e1tkami studovan\u00fdmi prost\u0159ednictv\u00edm jejich vlastn\u00edho biochemick\u00e9ho c\u00edle. Zat\u00edmco GHK-Cu se zam\u011b\u0159uje na koordinaci kov\u016f a souvisej\u00edc\u00ed bioanorganickou chemii, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly receptorov\u011b v\u00e1zan\u00e9 nebo enzymatick\u00e9 c\u00edle. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>GHK-Cu (glycyl-L-histidyl-L-lysin, komplex m\u011bdi(II))<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>m\u011b\u010fnat\u00fd tripeptid-1; Cu-GHK<\/td>\n<\/tr>\n<tr>\n<td>Sekvence<\/td>\n<td>Gly-His-Lys<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>89030-95-5 (komplex m\u011bdi(II)) 49557-75-7 (peptid GHK)<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost (peptid GHK)<\/td>\n<td>C<sub>14<\/sub>H<sub>24<\/sub>N<sub>6<\/sub>O<sub>4<\/sub> \/ 340,38 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>378611 (Cu-GHK) 342538 (GHK)<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Metalopeptid; m\u011b\u010fnat\u00fd(II) komplex tripeptidu<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>GHK-Cu se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg na lahvi\u010dku, uzav\u0159en\u00fd pry\u017eovou z\u00e1tkou s hlin\u00edkov\u00fdm uz\u00e1v\u011brem. Lyofiliz\u00e1t m\u00e1 modrou a\u017e modro\u0161edou barvu charakteristickou pro peptidy m\u011bdi(II); ta je odvozena od koordinovan\u00e9ho kovov\u00e9ho iontu, a proto je pro tuto t\u0159\u00eddu l\u00e1tek vlastn\u00ed. V laboratorn\u00edm prost\u0159ed\u00ed se materi\u00e1l zv\u00e1\u017e\u00ed a d\u00e1le zpracuje podle p\u0159\u00edslu\u0161n\u00e9ho analytick\u00e9ho protokolu, kde je hygroskopick\u00e9 chov\u00e1n\u00ed zn\u00e1m\u00fdm bodem pozornosti.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe v p\u016fvodn\u00edm obalu; komplexy m\u011bdi(II) jsou citliv\u00e9 na sv\u011btlo a oxida\u010dn\u00ed podm\u00ednky. Se slou\u010deninou zach\u00e1zejte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Lyofiliz\u00e1t obsahuje 50 mg GHK-Cu na lahvi\u010dku s kontrolovanou \u010distotou \u2265 99 % (HPLC). Nejsou p\u0159id\u00e1ny \u017e\u00e1dn\u00e9 plnidla ani stabiliz\u00e1tory, tak\u017ee nam\u011b\u0159en\u00fd pom\u011br m\u011bdi a peptidu nen\u00ed zkreslen pomocn\u00fdmi l\u00e1tkami.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>, kde jsou zpr\u00e1vy centr\u00e1ln\u011b shroma\u017e\u010fov\u00e1ny pro va\u0161e vlastn\u00ed v\u00fdzkumn\u00e9 z\u00e1znamy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed GHK-Cu?<\/strong><br \/>Metalopeptid: tripeptid Gly-His-Lys s jedn\u00edm koordinovan\u00fdm iontem m\u011bdi(II). Nejedn\u00e1 se tedy ani o \u010dist\u00fd peptid, ani o anorganickou s\u016fl m\u011bdi, ale o komplex obou.<\/p>\n<p><strong>Jakou roli hraje iont m\u011bdi ve zkouman\u00e9m mechanismu?<\/strong><br \/>Je dr\u017een N-termin\u00e1ln\u00ed aminoskupinou, amidov\u00fdm atomem dus\u00edku prvn\u00ed peptidov\u00e9 vazby a imidazolem histidinu. Tato geometrie ur\u010duje vazebnou s\u00edlu a poskytuje absorp\u010dn\u00ed p\u00e1smo dd pro spektroskopickou kontrolu.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd, modr\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg v uzav\u0159en\u00e9 lahvi\u010dce, bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladu a temnu, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe neotev\u0159en\u00e9 v p\u016fvodn\u00edm obalu.<\/p>","protected":false},"excerpt":{"rendered":"<p>GHK-Cu: lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 lahvi\u010dce.<\/p>","protected":false},"featured_media":3217,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[125,121],"product_tag":[],"class_list":["post-2877","product","type-product","status-publish","has-post-thumbnail","product_cat-herstel-reparatie","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2877"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2877\/revisions"}],"predecessor-version":[{"id":2949,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2877\/revisions\/2949"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3217"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2877"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2877"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2877"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}