{"id":2867,"date":"2026-09-01T09:32:43","date_gmt":"2026-09-01T09:32:43","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2867"},"modified":"2026-09-02T12:15:01","modified_gmt":"2026-09-02T12:15:01","slug":"thymosin-alpha-1-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/thymosin-alpha-1-vial-10-mg\/","title":{"rendered":"Thymosin Alpha-1 injek\u010dn\u00ed lahvi\u010dka 10 mg"},"content":{"rendered":"<p>Thymosin alfa-1 je syntetick\u00fd polypeptid z t\u0159\u00eddy thymick\u00fdch peptid\u016f, chemicky line\u00e1rn\u00ed, N-termin\u00e1ln\u011b acetylovan\u00fd peptid o 28 aminokyselin\u00e1ch. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro receptorem zprost\u0159edkovanou sign\u00e1ln\u00ed transdukci a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je thymosin alfa-1?<\/h2>\n<p>Thymosin alfa-1 (thymalfasin, T\u03b11) je polypeptid se sekvenc\u00ed Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, kter\u00e1 strukturn\u011b odpov\u00edd\u00e1 N-termin\u00e1ln\u00edmu fragmentu prekurzorov\u00e9ho proteinu prothymosinu alfa (113 aminokyselin). Molekula m\u00e1 siln\u011b kysel\u00fd charakter d\u00edky vysok\u00e9mu pod\u00edlu zbytk\u016f kyseliny glutamov\u00e9 a kyseliny asparagov\u00e9 a neobsahuje cystein, a proto \u017e\u00e1dn\u00e9 disulfidov\u00e9 m\u016fstky. Tato struktura \u2013 kr\u00e1tk\u00fd, nev\u00e1zan\u00fd \u0159et\u011bzec bez terci\u00e1rn\u00ed struktury s definovanou chemickou modifikac\u00ed \u2013 \u010din\u00ed z t\u00e9to slou\u010deniny reprodukovateln\u00fd model v peptidov\u00e9 chemii a v\u00fdzkumu struktury a aktivity.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech je thymosin alfa-1 prim\u00e1rn\u011b studov\u00e1n z hlediska jeho interakce s Toll-like receptory, zejm\u00e9na TLR2 a TLR9, na izolovan\u00fdch myeloidn\u00edch bu\u0148k\u00e1ch. In vitro bylo pops\u00e1no, \u017ee vazba na tento receptor moduluje sign\u00e1ln\u00ed dr\u00e1hy downstream, v\u010detn\u011b NF-\u03baB, p38 MAPK a IRF3, a \u017ee v bun\u011b\u010dn\u00fdch modelech je katabolismus tryptofanu ovlivn\u011bn enzymem indoleamin-2,3-dioxygen\u00e1zou (IDO). N-termin\u00e1ln\u00ed acetylace se zd\u00e1 b\u00fdt ur\u010duj\u00edc\u00edm faktorem pro stupe\u0148 interakce receptor\u016f v bun\u011b\u010dn\u00fdch modelech, co\u017e umo\u017e\u0148uje srovn\u00e1vac\u00ed v\u00fdzkum s neacetylovan\u00fdmi analogy. V d\u016fsledku toho se thymosin alfa-1 pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se thymosin alfa-1 vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>V\u00fdzkum receptor\u016f podobn\u00fdch Tollu (TLR2 a TLR9) a souvisej\u00edc\u00ed afinity ligand-receptor v izolovan\u00fdch bun\u011b\u010dn\u00fdch modelech in vitro.<\/li>\n<li>Enzymologick\u00fd v\u00fdzkum modulace katabolismu indoleamin-2,3-dioxygen\u00e1zy a tryptofanu v bun\u011b\u010dn\u00fdch kultiva\u010dn\u00edch syst\u00e9mech.<\/li>\n<li>V\u00fdzkum intracelul\u00e1rn\u00ed sign\u00e1ln\u00ed transdukce s kask\u00e1dami zprost\u0159edkovan\u00fdmi NF-\u03baB, p38-MAPK a IRF3 jako v\u00fdstupn\u00edmi parametry.<\/li>\n<li>V\u00fdzkum struktury a aktivity zam\u011b\u0159en\u00fd na roli N-termin\u00e1ln\u00ed acetylace a kysel\u00fdch aminokyselinov\u00fdch zbytk\u016f v kr\u00e1tk\u00fdch peptidov\u00fdch \u0159et\u011bzc\u00edch.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS, anal\u00fdza aminokyselin) s pou\u017eit\u00edm thymosinu alfa-1 jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a rozpustnosti lyofilizovan\u00fdch polypeptid\u016f za kontrolovan\u00fdch teplotn\u00edch a pH podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Thymosin alfa-1 v na\u0161em v\u00fdzkumn\u00e9m sortimentu<\/h2>\n<p>Thymosin Alpha-1 spad\u00e1 v na\u0161\u00ed produktov\u00e9 \u0159ad\u011b do kategorie lyofilizovan\u00fdch peptid\u016f ve form\u011b lahvi\u010dek. Zat\u00edmco tato slou\u010denina c\u00edl\u00ed na receptorem zprost\u0159edkovanou sign\u00e1ln\u00ed transdukci prost\u0159ednictv\u00edm Toll-like receptor\u016f, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly enzymatick\u00e9, s r\u016fstov\u00fdmi faktory v\u00e1zan\u00e9 nebo s membr\u00e1nou v\u00e1zan\u00e9 c\u00edle. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dky a souvisej\u00edc\u00ed po\u017eadavky na manipulaci, ale z\u00e1sadn\u011b se li\u0161\u00ed v aminokyselinov\u00e9 sekvenci, molekul\u00e1rn\u00ed velikosti a zkouman\u00e9m mechanismu.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>Thymosin alfa-1<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>thymalfasin; Ta1; Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>62304-98-7<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>129<\/sub>H<sub>215<\/sub>N<sub>33<\/sub>O<sub>55<\/sub> \/ 3108,3 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>16130571<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Syntetick\u00fd polypeptid (28 aminokyselin), thymick\u00fd peptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Lyofilizov\u00e1no, skladovat na chladn\u00e9m a such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bno p\u0159ed sv\u011btlem; dlouhodob\u00e9 skladov\u00e1n\u00ed p\u0159i teplot\u011b -20 \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Thymosin Alpha-1 se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek se standardizovan\u00fdm mno\u017estv\u00edm 10 mg na lahvi\u010dku. Na rozd\u00edl od pevn\u00fdch tablet se jedn\u00e1 o lyofiliz\u00e1t: materi\u00e1l se p\u0159ed analytickou prac\u00ed um\u00edst\u00ed do vhodn\u00e9ho rozpou\u0161t\u011bdla. Pr\u00e1\u0161ek m\u016f\u017ee le\u017eet jako tenk\u00e1 vrstva nebo sypk\u00fd kol\u00e1\u010d na dn\u011b nebo na st\u011bn\u011b lahvi\u010dky; to je vlastn\u00ed procesu lyofilizace.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a such\u00e9m m\u00edst\u011b chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem v p\u016fvodn\u00edm obalu; pro dlouhodob\u00e9 skladov\u00e1n\u00ed je obvykl\u00e1 teplota -20 \u00b0C. S l\u00e1tkou manipulujte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 ochrann\u00e9 prost\u0159edky, vyh\u00fdbejte se opakovan\u00fdm zm\u011bn\u00e1m teploty a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t m\u00e1 kontrolovanou \u010distotu \u2265 99 % (HPLC). Lahvi\u010dka obsahuje lyofilizovan\u00fd polypeptid bez p\u0159idan\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tek; mohou b\u00fdt p\u0159\u00edtomny zbytky pufrovac\u00edch sol\u00ed z v\u00fdrobn\u00edho procesu, co\u017e je b\u011b\u017en\u00e9 u synteticky p\u0159ipraven\u00fdch peptid\u016f.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy jsou tam centr\u00e1ln\u011b shroma\u017e\u010fov\u00e1ny pro va\u0161e vlastn\u00ed v\u00fdzkumn\u00e9 z\u00e1znamy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed thymosin alfa-1?<\/strong><br \/>Jedn\u00e1 se o syntetick\u00fd polypeptid o 28 aminokyselin\u00e1ch z t\u0159\u00eddy thymick\u00fdch peptid\u016f: nejedn\u00e1 se o malou organickou molekulu, ale o line\u00e1rn\u00ed \u0159et\u011bzec aminokyselin s acetylovou skupinou na N-konci.<\/p>\n<p><strong>Jakou roli hraje prothymosin alfa ve v\u00fdzkumu?<\/strong><br \/>Sekvence thymosinu alfa-1 odpov\u00edd\u00e1 N-termin\u00e1ln\u00ed oblasti prothymosinu alfa, prekurzorov\u00e9ho proteinu o d\u00e9lce 113 aminokyselin. Ve v\u00fdzkumn\u00fdch modelech se tento vztah pou\u017e\u00edv\u00e1 k ur\u010den\u00ed, kter\u00e1 \u010d\u00e1st \u0159et\u011bzce je zodpov\u011bdn\u00e1 za pozorovanou interakci receptoru in vitro.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) o hmotnosti 10 mg v uzav\u0159en\u00e9 lahvi\u010dce, s \u010distotou \u2265 99 % (HPLC).<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladu, suchu a chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem, nejl\u00e9pe v p\u016fvodn\u00edm obalu. Pro dlouhodob\u00e9 skladov\u00e1n\u00ed se obvykle udr\u017euje teplota -20 \u00b0C.<\/p>","protected":false},"excerpt":{"rendered":"<p>Lyofilizovan\u00fd thymosin alfa-1 (Thymalfasin, T\u03b11), syntetick\u00fd peptid s 28 aminokyselinami \u2013 \u010distota \u226599 % (HPLC). Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nen\u00ed ur\u010deno k lidsk\u00e9 ani zv\u00ed\u0159ec\u00ed spot\u0159eb\u011b. Nen\u00ed l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3235,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2867","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2867"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2867\/revisions"}],"predecessor-version":[{"id":2940,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2867\/revisions\/2940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3235"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2867"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2867"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2867"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}