{"id":2847,"date":"2026-09-01T09:31:28","date_gmt":"2026-09-01T09:31:28","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2847"},"modified":"2026-09-02T12:15:14","modified_gmt":"2026-09-02T12:15:14","slug":"5-amino-1mq-vial-50-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/5-amino-1mq-vial-50-mg\/","title":{"rendered":"5-Amino-1MQ injek\u010dn\u00ed lahvi\u010dka 50 mg"},"content":{"rendered":"<p>5-Amino-1MQ je syntetick\u00e1 mal\u00e1 molekula ze t\u0159\u00eddy kvart\u00e9rn\u00edch chinolinov\u00fdch sol\u00ed, chemicky 5-aminosubstituovan\u00fd 1-methylchinolinium. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro enzymologii methyltransfer\u00e1zy a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je 5-Amino-1MQ?<\/h2>\n<p>5-Amino-1MQ (1-methylchinolin-1-ium-5-amin, dod\u00e1van\u00fd jako jodidov\u00e1 s\u016fl) je mal\u00e1 organick\u00e1 molekula obklopuj\u00edc\u00ed bicyklick\u00fd chinolinov\u00fd skelet. Atom dus\u00edku v kruhu nese methylovou skupinu, co\u017e d\u00e1v\u00e1 molekule permanentn\u011b kladn\u011b nabit\u00e9 kvart\u00e9rn\u00ed chinolinov\u00e9 j\u00e1dro; aminoskupina se nach\u00e1z\u00ed v poloze 5. Tento fixn\u00ed n\u00e1boj ur\u010duje jej\u00ed chov\u00e1n\u00ed v laborato\u0159i: na rozd\u00edl od ionizovateln\u00e9ho aminu se n\u00e1boj nem\u011bn\u00ed s pH, co\u017e usnad\u0148uje manipulaci s molekulou v kationtov\u00e9 v\u00fdm\u011bnn\u00e9 chromatografii. Nav\u00edc elektronov\u011b bohat\u00fd aminosubstituent posouv\u00e1 absorp\u010dn\u00ed p\u00e1s konjugovan\u00e9ho kruhov\u00e9ho syst\u00e9mu a poskytuje z\u0159eteln\u00fd chromofor v UV oblasti. D\u00edky tomu je tato slou\u010denina \u0161iroce pou\u017e\u00edvanou modelovou molekulou p\u0159i studiu methyla\u010dn\u00edch reakc\u00ed z\u00e1visl\u00fdch na S-adenosylmethioninu.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech se 5-Amino-1MQ pou\u017e\u00edv\u00e1 ke studiu enzymu nikotinamid-N-methyltransfer\u00e1zy (NNMT). NNMT p\u0159en\u00e1\u0161\u00ed methylovou skupinu z kofaktoru S-adenosylmethioninu (SAM) na nikotinamid, co\u017e vede k tvorb\u011b 1-methylnikotinamidu a S-adenosylhomocysteinu. In vitro se 5-Amino-1MQ v\u00e1\u017ee na substr\u00e1tovou kapsu tohoto enzymu, a proto je v literatu\u0159e popisov\u00e1n jako inhibitor tohoto methyla\u010dn\u00edho kroku; nabit\u00fd chinoliniov\u00fd motiv napodobuje methylovanou pyridinovou strukturu reak\u010dn\u00edho produktu. N\u00e1sledn\u011b jsou d\u016fsledky pro nikotinamid a NAD zkoum\u00e1ny na bun\u011b\u010dn\u00fdch modelech.<sup>+<\/sup>-recykla\u010dn\u00ed cesta a pro z\u00e1sobu methylov\u00fdch donor\u016f. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu se proto 5-Amino-1MQ pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se 5-Amino-1MQ vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Enzymologick\u00e9 vy\u0161et\u0159en\u00ed nikotinamid-N-methyltransfer\u00e1zy (NNMT) a kinetiky SAM-dependentn\u00edho p\u0159enosu methylu in vitro.<\/li>\n<li>Modelov\u00e9 studie nikotinamidu a NAD<sup>+<\/sup>-recykla\u010dn\u00ed dr\u00e1ha v bun\u011b\u010dn\u00fdch modelech a bezbun\u011b\u010dn\u00fdch enzymov\u00fdch syst\u00e9mech.<\/li>\n<li>Studie vztahu struktury a aktivity analog\u016f chinolinia a isochinolinia jako inhibitor\u016f methyltransfer\u00e1zy.<\/li>\n<li>Biofyzik\u00e1ln\u00ed vazebn\u00e9 studie interakce mezi nabit\u00fdm chinolinov\u00fdm motivem a substr\u00e1tovou kapsou.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC s UV detekc\u00ed, LC-MS) s 5-Amino-1MQ jako referen\u010dn\u00edm standardem.<\/li>\n<li>Studie stability a rozpustnosti kvart\u00e9rn\u00edch amonn\u00fdch sol\u00ed za kontrolovan\u00fdch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>5-Amino-1MQ v na\u0161em v\u00fdzkumn\u00e9m sortimentu<\/h2>\n<p>5-Amino-1MQ spad\u00e1 do na\u0161\u00ed nab\u00eddky v r\u00e1mci lyofilizovan\u00fdch experiment\u00e1ln\u00edch slou\u010denin ve form\u011b lahvi\u010dek, co\u017e je kategorie, kterou v\u011bdci pravideln\u011b kombinuj\u00ed s l\u00e1tkami studovan\u00fdmi prost\u0159ednictv\u00edm jejich vlastn\u00edho biochemick\u00e9ho c\u00edle. Zat\u00edmco 5-Amino-1MQ se zam\u011b\u0159uje na methyltransfer\u00e1zu a s n\u00ed spojenou homeost\u00e1zu kofaktor\u016f, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly c\u00edle v\u00e1zan\u00e9 na receptory, koordinovan\u00e9 kovy nebo zprost\u0159edkovan\u00e9 peptidy. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>5-Amino-1MQ (5-amino-1-methylchinoliniumjodid)<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>1-methylchinolin-1-ium-5-amin jodid; chinolinium, 5-amino-1-methyl-, jodid (1:1); NNMTi<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>42464-96-0<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>10<\/sub>H<sub>11<\/sub>V<sub>2<\/sub> \/ 286,11 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>66522933<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Mal\u00e1 molekula, kvart\u00e9rn\u00ed chinoliniov\u00e1 s\u016fl; inhibitor nikotinamid-N-methyltransfer\u00e1zy<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>5-Amino-1MQ se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg na lahvi\u010dku, uzav\u0159en\u00fd pry\u017eovou z\u00e1tkou s hlin\u00edkov\u00fdm uz\u00e1v\u011brem. Jedn\u00e1 se o kvart\u00e9rn\u00ed amoniovou s\u016fl v pevn\u00e9 form\u011b; materi\u00e1l se zv\u00e1\u017e\u00ed v laboratorn\u00edm za\u0159\u00edzen\u00ed a d\u00e1le se zpracuje podle p\u0159\u00edslu\u0161n\u00e9ho analytick\u00e9ho nebo enzymologick\u00e9ho protokolu. Hygroskopick\u00e9 chov\u00e1n\u00ed je u t\u00e9to t\u0159\u00eddy l\u00e1tek zn\u00e1m\u00fdm faktorem, na kter\u00fd je t\u0159eba v\u011bnovat pozornost.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe v p\u016fvodn\u00edm obalu. Jodidov\u00e9 soli jsou citliv\u00e9 na dlouhodob\u00e9 vystaven\u00ed sv\u011btlu, kter\u00e9 m\u016f\u017ee zp\u016fsobit zm\u011bnu barvy pr\u00e1\u0161ku. S p\u0159\u00edpravkem manipulujte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Lyofiliz\u00e1t obsahuje 50 mg 5-Amino-1MQ na lahvi\u010dku s kontrolovanou \u010distotou \u2265 99 % (HPLC). Nejsou p\u0159id\u00e1ny \u017e\u00e1dn\u00e9 stabiliz\u00e1tory ani plnidla, tak\u017ee slou\u010denina z\u016fst\u00e1v\u00e1 pou\u017eiteln\u00e1 jako referen\u010dn\u00ed materi\u00e1l v analytick\u00fdch prac\u00edch.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>, kde jsou zpr\u00e1vy centr\u00e1ln\u011b shroma\u017e\u010fov\u00e1ny pro va\u0161e vlastn\u00ed v\u00fdzkumn\u00e9 z\u00e1znamy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed 5-Amino-1MQ?<\/strong><br \/>Mal\u00e1 syntetick\u00e1 molekula: kvart\u00e9rn\u00ed chinoliniov\u00e1 s\u016fl s aminoskupinou v poloze 5, dod\u00e1van\u00e1 jako jodidov\u00e1 s\u016fl. Nen\u00ed to peptid, a proto neobsahuje \u017e\u00e1dnou aminokyselinovou sekvenci.<\/p>\n<p><strong>Kter\u00fd enzym je \u00fast\u0159edn\u00edm bodem zkouman\u00e9ho mechanismu?<\/strong><br \/>Nikotinamid-N-methyltransfer\u00e1za (NNMT). In vitro tento enzym p\u0159en\u00e1\u0161\u00ed methylovou skupinu z S-adenosylmethioninu na nikotinamid; 5-Amino-1MQ je v literatu\u0159e pops\u00e1n jako inhibitor tohoto kroku.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 50 mg v uzav\u0159en\u00e9 lahvi\u010dce, bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladu a temnu, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe neotev\u0159en\u00e9 v p\u016fvodn\u00edm obalu.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"825\" data-end=\"885\">5-amino-1MQ \u2013 Mal\u00e1 molekula pro v\u00fdzkumn\u00e9 aplikace<\/strong><br data-start=\"885\" data-end=\"888\" \/>5-amino-1MQ (5-amino-1-methylchinolinium) je syntetick\u00e1 mal\u00e1 molekula pou\u017e\u00edvan\u00e1 v laboratorn\u00edm a preklinick\u00e9m v\u00fdzkumu. Molekula se pou\u017e\u00edv\u00e1 pro studie zkoumaj\u00edc\u00ed chemickou stabilitu, molekul\u00e1rn\u00ed interakce a experiment\u00e1ln\u00ed sign\u00e1ln\u00ed dr\u00e1hy. 5-amino-1MQ nen\u00ed spot\u0159ebn\u00ed produkt a nen\u00ed ur\u010den pro fyziologick\u00e9, l\u00e9ka\u0159sk\u00e9 ani nutri\u010dn\u00ed aplikace.<\/p>","protected":false},"featured_media":3238,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2847","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2847"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2847\/revisions"}],"predecessor-version":[{"id":2924,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2847\/revisions\/2924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3238"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2847"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2847"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2847"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}