{"id":2844,"date":"2026-09-01T09:31:06","date_gmt":"2026-09-01T09:31:06","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2844"},"modified":"2026-09-02T12:14:43","modified_gmt":"2026-09-02T12:14:43","slug":"nad-vial-1000-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/nad-vial-1000-mg\/","title":{"rendered":"NAD+ lahvi\u010dka 1000 mg"},"content":{"rendered":"<p>NAD+ (nikotinamid-adenin-dinukleotid) je p\u0159irozen\u011b se vyskytuj\u00edc\u00ed koenzym, chemicky dinukleotid slo\u017een\u00fd z nikotinamidu a adeninov\u00e9ho nukleotidu. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro redoxn\u00ed biochemii a kinetiku enzym\u016f a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 1000 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je NAD+?<\/h2>\n<p>NAD+ (\u03b2-nikotinamid-adenin-dinukleotid) je dinukleotid, ve kter\u00e9m jsou dva ribonukleotidy spojeny prost\u0159ednictv\u00edm sv\u00fdch 5'-fosf\u00e1tov\u00fdch skupin a tvo\u0159\u00ed pyrofosf\u00e1tov\u00fd m\u016fstek: adenin-ribonukleotid na jedn\u00e9 stran\u011b a nikotinamid-ribonukleotid s kladn\u011b nabit\u00fdm pyridiniov\u00fdm kruhem na druh\u00e9 stran\u011b. Tato asymetrick\u00e1 struktura \u2013 rozpoznateln\u00e1 adenosinov\u00e1 oblast vedle redoxn\u011b aktivn\u00edho pyridiniov\u00e9ho kruhu \u2013 \u010din\u00ed z t\u00e9to slou\u010deniny \u0161iroce pou\u017e\u00edvan\u00fd model p\u0159i studiu rozpozn\u00e1v\u00e1n\u00ed kofaktor\u016f, geometrie vazebn\u00e9ho m\u00edsta a p\u0159enosu elektron\u016f.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech funguje NAD+ jako reverzibiln\u00ed akceptor hydrid\u016f: nikotinamidov\u00fd kruh p\u0159ij\u00edm\u00e1 hydridov\u00fd iont v poloze C4, co\u017e vede k redukovan\u00e9 form\u011b NADH. Tento p\u00e1r NAD+\/NADH tvo\u0159\u00ed z\u00e1klad mnoha in vitro enzymatick\u00fdch test\u016f, proto\u017ee p\u0159em\u011bnu lze monitorovat spektrofotometricky charakteristickou absorpc\u00ed NADH p\u0159i 340 nm. NAD+ je nav\u00edc studov\u00e1n v bun\u011b\u010dn\u00fdch modelech jako kosubstr\u00e1t pro enzymy spot\u0159ebov\u00e1vaj\u00edc\u00ed NAD+, jako jsou sirtuiny, poly(ADP-rib\u00f3za)polymer\u00e1zy a CD38, kter\u00e9 \u0161t\u011bp\u00ed glykosidickou vazbu mezi nikotinamidem a ADP-rib\u00f3zou, \u010d\u00edm\u017e uvol\u0148uj\u00ed nikotinamid. V d\u016fsledku toho se NAD+ pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se NAD+ vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Studie enzymov\u00e9 kinetiky NAD+-dependentn\u00edch dehydrogen\u00e1z, ve kter\u00e9 je p\u00e1r NAD+\/NADH spektrofotometricky monitorov\u00e1n in vitro.<\/li>\n<li>V\u00fdzkum enzym\u016f spot\u0159ebov\u00e1vaj\u00edc\u00edch NAD+ (sirtuiny, poly(ADP-rib\u00f3za)polymer\u00e1zy, CD38) a jejich z\u00e1vislosti na kosebstr\u00e1tech v bezbun\u011b\u010dn\u00fdch syst\u00e9mech.<\/li>\n<li>Biochemick\u00e9 modelov\u00e9 studie z\u00e1chrann\u00e9 dr\u00e1hy a enzym\u016f NAMPT a NMNAT zapojen\u00fdch do tvorby dinukleotidov\u00fdch kofaktor\u016f.<\/li>\n<li>Redoxn\u00ed biochemie a v\u00fdzkum struktury a aktivity pyridinov\u00fdch nukleotid\u016f a jejich strukturn\u00edch analog\u016f.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS) s pou\u017eit\u00edm NAD+ jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a rozpustnosti lyofilizovan\u00fdch nukleotidov\u00fdch kofaktor\u016f za kontrolovan\u00fdch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>NAD+ v r\u00e1mci na\u0161eho v\u00fdzkumn\u00e9ho sortimentu<\/h2>\n<p>NAD+ spad\u00e1 v na\u0161\u00ed produktov\u00e9 \u0159ad\u011b do kategorie lyofilizovan\u00fdch experiment\u00e1ln\u00edch slou\u010denin ve form\u011b lahvi\u010dek. Zat\u00edmco NAD+ je zkoum\u00e1n jako koenzym a kosubstr\u00e1t v enzymatick\u00fdch a redoxn\u011b orientovan\u00fdch syst\u00e9mech, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly c\u00edle v\u00e1zan\u00e9 na receptory nebo sign\u00e1ln\u00ed transdukci. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu a balen\u00ed ve form\u011b lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>NAD+ (nikotinamid adenin dinukleotid)<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>\u03b2-NAD; \u03b2-nikotinamidadenin dinukleotid; difosfopyridin nukleotid (DPN); koenzym I<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>53-84-9<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>21<\/sub>H<sub>27<\/sub>N<sub>7<\/sub>O<sub>14<\/sub>P<sub>2<\/sub> \/ 663,43 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>5892<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Dinukleotidov\u00fd koenzym, redoxn\u00ed kofaktor (nepeptidov\u00fd)<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>1000 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Uchov\u00e1vejte v chladni\u010dce, chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>NAD+ se dod\u00e1v\u00e1 jako lyofilizovan\u00fd b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd pr\u00e1\u0161ek se standardizovan\u00fdm mno\u017estv\u00edm 1000 mg na lahvi\u010dku. Na rozd\u00edl od pevn\u00e9 tablety je lyofiliz\u00e1t ur\u010den k rozpu\u0161t\u011bn\u00ed ve vhodn\u00e9m rozpou\u0161t\u011bdle p\u0159ed analytickou prac\u00ed; volba rozpou\u0161t\u011bdla a pou\u017eit\u00e1 koncentrace z\u00e1vis\u00ed v\u00fdhradn\u011b na analytick\u00e9m protokolu samotn\u00e9 laborato\u0159e.<\/p>\n<p>Lahvi\u010dku skladujte v chladni\u010dce v p\u016fvodn\u00edm obalu, chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem a vlhkost\u00ed. Dinukleotid je citliv\u00fd na vlhkost a opakovan\u00e9 zm\u011bny teploty. Se slou\u010deninou manipulujte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t se vyr\u00e1b\u00ed s kontrolovanou \u010distotou \u2265 99 % (HPLC). Lahvi\u010dka obsahuje slou\u010deninu ve form\u011b such\u00e9ho pr\u00e1\u0161ku bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek, co\u017e z n\u011bj \u010din\u00ed vhodn\u00fd referen\u010dn\u00ed materi\u00e1l v analytick\u00fdch aplikac\u00edch.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy se shroma\u017e\u010fuj\u00ed centr\u00e1ln\u011b tam, abyste mohli data za\u010dlenit do vlastn\u00edch v\u00fdzkumn\u00fdch z\u00e1znam\u016f.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed NAD+?<\/strong><br \/>NAD+ nen\u00ed peptid, ale dinukleotidov\u00fd koenzym: dva ribonukleotidy (adenin a nikotinamid) spojen\u00e9 pyrofosf\u00e1tov\u00fdm m\u016fstkem. Neobsahuje tedy \u017e\u00e1dnou aminokyselinovou sekvenci a pat\u0159\u00ed do t\u0159\u00eddy pyridinov\u00fdch nukleotidov\u00fdch kofaktor\u016f.<\/p>\n<p><strong>Jak\u00fd je rozd\u00edl mezi NAD+ a NADH ve v\u00fdzkumu?<\/strong><br \/>NAD+ je oxidovan\u00e1 forma a NADH redukovan\u00e1 forma t\u00e9\u017ee molekuly. In vitro nikotinamidov\u00fd kruh v poloze C4 p\u0159ij\u00edm\u00e1 hydridov\u00fd iont za vzniku NADH. Proto\u017ee pouze NADH siln\u011b absorbuje p\u0159i 340 nm, lze tuto p\u0159em\u011bnu p\u0159\u00edmo sledovat spektrofotometricky v enzymatick\u00e9 anal\u00fdze.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 1000 mg v uzav\u0159en\u00e9 lahvi\u010dce, bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek. Pr\u00e1\u0161ek se p\u0159ed analytick\u00fdm pou\u017eit\u00edm rozpust\u00ed ve vhodn\u00e9m rozpou\u0161t\u011bdle v laboratorn\u00edm za\u0159\u00edzen\u00ed.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladni\u010dce, chr\u00e1n\u011bn\u00e9 p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe neotev\u0159en\u00e9 v p\u016fvodn\u00edm obalu. Zabra\u0148te opakovan\u00fdm zm\u011bn\u00e1m teploty.<\/p>","protected":false},"excerpt":{"rendered":"<p>NAD+ (nikotinamidadenin dinukleotid) je dinukleotidov\u00fd koenzym (nepeptidov\u00fd), kter\u00fd p\u016fsob\u00ed jako redoxn\u00ed kofaktor. Je studov\u00e1n jako modelov\u00e1 slou\u010denina ve v\u011bdeck\u00e9m v\u00fdzkumu. Je ur\u010den v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nen\u00ed ur\u010den k lidsk\u00e9 ani zv\u00ed\u0159ec\u00ed spot\u0159eb\u011b. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek ani dopln\u011bk stravy.<\/p>","protected":false},"featured_media":3229,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[135,120,121],"product_tag":[],"class_list":["post-2844","product","type-product","status-publish","has-post-thumbnail","product_cat-aanbevolen","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2844"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2844\/revisions"}],"predecessor-version":[{"id":2918,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2844\/revisions\/2918"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3229"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2844"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2844"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2844"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}