{"id":2819,"date":"2026-09-01T09:29:42","date_gmt":"2026-09-01T09:29:42","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2819"},"modified":"2026-09-02T12:24:37","modified_gmt":"2026-09-02T12:24:37","slug":"selank","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/selank\/","title":{"rendered":"Selank"},"content":{"rendered":"<h2>Co je Selank?<\/h2>\n<p>Selank je syntetick\u00fd line\u00e1rn\u00ed heptapeptid s aminokyselinovou sekvenc\u00ed Thr-Lys-Pro-Arg-Pro-Gly-Pro. \u0158et\u011bzec se skl\u00e1d\u00e1 z p\u0159irozen\u011b se vyskytuj\u00edc\u00edho tetrapeptidov\u00e9ho motivu (Thr-Lys-Pro-Arg), ke kter\u00e9mu je na C-konci p\u0159ipojen tripeptid Pro-Gly-Pro. Slou\u010denina m\u00e1 \u010d\u00edslo CAS 129954-34-3 a molekul\u00e1rn\u00ed vzorec C.<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> a molekulovou hmotnost p\u0159ibli\u017en\u011b 751,9 Da (PubChem CID 11765600).<\/p>\n<p>Se t\u0159emi prolinov\u00fdmi zbytky v sedmi pozic\u00edch je Selank sekvenc\u00ed v\u00fdrazn\u011b bohatou na prolin. Prolin omezuje rota\u010dn\u00ed volnost hlavn\u00edho \u0159et\u011bzce a sekvence prolin-glycin-prolin na C-termin\u00e1ln\u00edm konci zvy\u0161uje rigiditu tohoto konce, \u010d\u00edm\u017e omezuje napaden\u00ed exopeptid\u00e1zami; v laboratorn\u00edch podm\u00ednk\u00e1ch je d\u00edky tomu \u0159et\u011bzec m\u011b\u0159iteln\u011b stabiln\u011bj\u0161\u00ed ne\u017e neprodlou\u017een\u00fd tetrapeptidov\u00fd motiv, kter\u00fd se v definovan\u00fdch pufrovac\u00edch syst\u00e9mech rychle degraduje. Dva siln\u011b bazick\u00e9 zbytky \u2013 lysin a arginin \u2013 nav\u00edc d\u00e1vaj\u00ed molekule vysok\u00fd izoelektrick\u00fd bod a v\u00fdrazn\u011b hydrofiln\u00ed charakter, zat\u00edmco \u0159et\u011bzec neobsahuje \u017e\u00e1dn\u00e9 aromatick\u00e9 zbytky. Detekce se tedy nespol\u00e9h\u00e1 na absorpci p\u0159i 280 nm, ale na samotnou peptidovou vazbu v okol\u00ed 210\u2013220 nm. Tato kombinace rigidity \u0159et\u011bzce, vysok\u00e9 hydrofilnosti a absence chromoforu \u010din\u00ed ze Selanku instruktivn\u00ed modelovou slou\u010deninu ve srovn\u00e1vac\u00edm v\u00fdzkumu peptid\u016f a ve v\u00fdvoji analytick\u00fdch metod.<\/p>\n<h2>Aplikace v laboratorn\u00edm kontextu<\/h2>\n<p>V r\u00e1mci peptidov\u00e9 chemie a analytick\u00e9 pr\u00e1ce se Selank mimo jin\u00e9 v\u011bnuje n\u00e1sleduj\u00edc\u00edm oblastem v\u00fdzkumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdzkum vztahu struktura-aktivita<\/strong> k p\u0159\u00edsp\u011bvku Pro-Gly-Pro konce, kde je prodlou\u017een\u00e1 sekvence pod\u00e9l neroz\u0161\u00ed\u0159en\u00e9ho tetrapeptidov\u00e9ho motivu charakterizov\u00e1na rigiditou \u0159et\u011bzce, profilem n\u00e1boje a chromatografick\u00fdm chov\u00e1n\u00edm.<\/li>\n<li><strong>V\u00fdzkum peptidov\u00e9 chemie<\/strong> t\u00fdkaj\u00edc\u00ed se chov\u00e1n\u00ed kr\u00e1tk\u00fdch, na prolin bohat\u00fdch a vysoce hydrofiln\u00edch \u0159et\u011bzc\u016f: rozpustnost, retence v reverzn\u00ed f\u00e1zov\u00e9 chromatografii p\u0159i n\u00edzk\u00e9m organick\u00e9m pod\u00edlu a cis-trans izomerismus kolem prolinov\u00e9 peptidov\u00e9 vazby jako zdroj roz\u0161\u00ed\u0159en\u00ed p\u00edku.<\/li>\n<li><strong>Studie enzymatick\u00e9 stability<\/strong> ve kter\u00e9m je rychlost degradace amino- a karboxypeptid\u00e1zami monitorov\u00e1na v definovan\u00fdch pufrovac\u00edch syst\u00e9mech a v\u00fdsledn\u00e9 fragmenty jsou p\u0159i\u0159azeny hmotnostn\u00ed spektrometri\u00ed.<\/li>\n<li><strong>V\u00fdvoj a validace analytick\u00fdch metod<\/strong> (HPLC, LC-MS, mapov\u00e1n\u00ed peptid\u016f), kde Selank slou\u017e\u00ed jako referen\u010dn\u00ed standard pro sekvence bez aromatick\u00e9ho chromoforu, s detekc\u00ed amidov\u00e9 vazby v dalek\u00e9 UV oblasti a s potvrzen\u00edm identity hmotnostn\u00ed spektrometri\u00ed.<\/li>\n<\/ul>\n<h2>Specifikace<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Ochutnat<\/strong><\/td>\n<td>Selank<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u00e9lka peptidu<\/strong><\/td>\n<td>7 aminokyselinov\u00fdch zbytk\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>Sekvence<\/strong><\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>129954-34-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/strong><\/td>\n<td>C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \/ cca 751,9 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u0159\u00edda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rn\u00ed heptapeptid bohat\u00fd na prolin s C-termin\u00e1ln\u00edm motivem Pro-Gly-Pro<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1\u0159<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td>Lyofilizov\u00e1no p\u0159i 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>The material is supplied as freeze-dried powder (lyophilisate) in a sealed glass vial with a septum and shrink cap. The lyophilisate is white to off-white and presents as a compact cake or as a fine powder; both are normal appearances of the freeze-drying process. The material is hygroscopic \u2014 all the more so in a strongly hydrophilic, basic sequence \u2014 and therefore remains closed in the original packaging until it is processed in the laboratory.<\/p>\n<p>Store the unopened lyophilized lyophilized powder refrigerated at 2\u20138 \u00b0C, in a dry and dark place, protected from light and moisture; for longer storage periods, it is usually stored frozen. Allow the vial to reach room temperature before opening to minimize condensation, work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other laboratory materials. Dispose of residual material in accordance with applicable laboratory guidelines.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>For short, proline-rich chains, identity and purity are the determining parameters: shortened chains and deletion variants differ only slightly in retention, and the absence of an aromatic chromophore places additional demands on detection. Our Selank is supplied with a purity of \u2265 99%, determined by HPLC analysis in accordance with the corresponding certificate of analysis. The available certificates of analysis can be viewed on our website. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<h2>D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed<\/h2>\n<p>Tento produkt dod\u00e1v\u00e1me v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum a analytick\u00e9 pr\u00e1ce. Nen\u00ed ur\u010den pro diagnostick\u00e9 ani terapeutick\u00e9 aplikace a v\u00fdslovn\u011b nen\u00ed ur\u010den k pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Tento produkt nen\u00ed potravinou, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani registrovan\u00fdm l\u00e9\u010div\u00fdm p\u0159\u00edpravkem. Zakoupen\u00edm tohoto produktu kupuj\u00edc\u00ed potvrzuje, \u017ee je star\u0161\u00ed 18 let a bude jej pou\u017e\u00edvat v\u00fdhradn\u011b v kontrolovan\u00e9m v\u00fdzkumn\u00e9m nebo laboratorn\u00edm prost\u0159ed\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Selank je syntetick\u00fd line\u00e1rn\u00ed heptapeptid (C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub>, p\u0159ibli\u017en\u011b 751,9 g\/mol) se t\u0159emi prolinov\u00fdmi zbytky a C-termin\u00e1ln\u00edm motivem Pro-Gly-Pro, kter\u00fd zpev\u0148uje konec \u0159et\u011bzce. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina v peptidov\u00e9 chemii a analytick\u00fdch prac\u00edch. Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nikoli pro pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3232,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,121],"product_tag":[],"class_list":["post-2819","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2819"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2819\/revisions"}],"predecessor-version":[{"id":2893,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2819\/revisions\/2893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3232"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2819"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2819"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2819"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}