{"id":2810,"date":"2026-09-01T09:28:24","date_gmt":"2026-09-01T09:28:24","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2810"},"modified":"2026-09-02T09:25:59","modified_gmt":"2026-09-02T09:25:59","slug":"selank-neusspray-kit","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/selank-neusspray-kit\/","title":{"rendered":"Nosn\u00ed sprej Selank"},"content":{"rendered":"<h2>Co je Selank?<\/h2>\n<p>Selank je syntetick\u00fd line\u00e1rn\u00ed heptapeptid: \u0159et\u011bzec sedmi aminokyselinov\u00fdch zbytk\u016f se sekvenc\u00ed Thr-Lys-Pro-Arg-Pro-Gly-Pro. Slou\u010denina je zn\u00e1m\u00e1 pod \u010d\u00edslem CAS 129954-34-3, s molekul\u00e1rn\u00edm vzorcem C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> (p\u0159ibli\u017en\u011b 751,9 g\/mol) a PubChem CID 11765600. Prvn\u00ed \u010dty\u0159i zbytky (Thr-Lys-Pro-Arg) tvo\u0159\u00ed p\u0159irozen\u011b se vyskytuj\u00edc\u00ed tetrapeptidov\u00fd fragment; tripeptid Pro-Gly-Pro je k n\u011bmu nav\u00e1z\u00e1n na C-konci.<\/p>\n<p>Se t\u0159emi prolinov\u00fdmi zbytky v sedmi pozic\u00edch je Selank v\u00fdrazn\u011b prolin-bohat\u00fd \u0159et\u011bzec. Sekvence prolin-glycin-prolin na C-termin\u00e1ln\u00edm konci zvy\u0161uje rigiditu t\u00e9to \u010d\u00e1sti \u0159et\u011bzce a omezuje napaden\u00ed exopeptid\u00e1zami, d\u00edky \u010demu\u017e je sekvence v laboratorn\u00edch podm\u00ednk\u00e1ch m\u011b\u0159iteln\u011b stabiln\u011bj\u0161\u00ed ne\u017e nerozta\u017een\u00fd tetrapeptidov\u00fd fragment. Lysinov\u00e9 a argininov\u00e9 zbytky nav\u00edc zaji\u0161\u0165uj\u00ed v\u00fdrazn\u011b bazick\u00fd profil n\u00e1boje: p\u0159i neutr\u00e1ln\u00edm pH nese molekula \u010dist\u00fd kladn\u00fd n\u00e1boj, kter\u00fd do zna\u010dn\u00e9 m\u00edry ur\u010duje jej\u00ed reten\u010dn\u00ed chov\u00e1n\u00ed v reverzn\u00ed f\u00e1zov\u00e9 chromatografii s p\u0159\u00edsadami pro p\u00e1rov\u00e1n\u00ed iont\u016f. \u0158et\u011bzec nav\u00edc neobsahuje \u017e\u00e1dn\u00e9 aromatick\u00e9 zbytky, tak\u017ee detekce p\u0159i 280 nm neposkytuje t\u00e9m\u011b\u0159 \u017e\u00e1dn\u00fd sign\u00e1l a typicky se m\u011b\u0159\u00ed na peptidov\u00e9m m\u016fstku kolem 214 nm. Tato kombinace kr\u00e1tk\u00e9, pln\u011b zapsan\u00e9 sekvence, rigidn\u00edho C-konce a ost\u0159e definovan\u00e9ho profilu n\u00e1boje \u010din\u00ed ze Selanku vysoce reprodukovatelnou modelovou slou\u010deninu v komparativn\u00edm v\u00fdzkumu peptid\u016f.<\/p>\n<h2>Aplikace v laboratorn\u00edm kontextu<\/h2>\n<p>V r\u00e1mci peptidov\u00e9 chemie a analytick\u00e9 pr\u00e1ce se Selank mimo jin\u00e9 v\u011bnuje n\u00e1sleduj\u00edc\u00edm oblastem v\u00fdzkumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdzkum vztahu struktura-aktivita<\/strong> k p\u0159\u00edsp\u011bvku C-termin\u00e1ln\u00edho motivu Pro-Gly-Pro a bazick\u00fdch zbytk\u016f ke konformaci \u0159et\u011bzce, distribuci n\u00e1boje a chromatografick\u00e9mu chov\u00e1n\u00ed.<\/li>\n<li><strong>V\u00fdzkum peptidov\u00e9 chemie<\/strong> sm\u011brem k rozpustnosti a agrega\u010dn\u00ed tendenci siln\u011b bazick\u00fdch, na prolin bohat\u00fdch \u0159et\u011bzc\u016f ve vodn\u00e9m prost\u0159ed\u00ed p\u0159i r\u016fzn\u00e9m pH a iontov\u00e9 s\u00edle.<\/li>\n<li><strong>Studie enzymatick\u00e9 stability<\/strong> ve kter\u00e9m je rozpad \u0159et\u011bzce monitorov\u00e1n za definovan\u00fdch podm\u00ednek pH, teploty a enzymu a vznikl\u00e9 fragmenty jsou charakterizov\u00e1ny hmotnostn\u00ed spektrometri\u00ed.<\/li>\n<li><strong>V\u00fdvoj a validace analytick\u00fdch metod<\/strong> (HPLC, LC-MS, mapov\u00e1n\u00ed peptid\u016f), kde absence aromatick\u00fdch zbytk\u016f vy\u017eaduje detekci p\u0159i n\u00edzk\u00fdch vlnov\u00fdch d\u00e9lk\u00e1ch a siln\u00e1 bazicita \u0159et\u011bzce vy\u017eaduje pe\u010dliv\u011b zvolen\u00e9 podm\u00ednky iontov\u00e9ho p\u00e1rov\u00e1n\u00ed.<\/li>\n<\/ul>\n<h2>Specifikace<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Ochutnat<\/strong><\/td>\n<td>Selank (syntetick\u00fd heptapeptid) jako roztok peptidu v uzav\u0159en\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u00e9lka peptidu<\/strong><\/td>\n<td>7 aminokyselinov\u00fdch zbytk\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>Sekvence<\/strong><\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>129954-34-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/strong><\/td>\n<td>C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \/ p\u0159ibli\u017en\u011b 751,9 g\/mol<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u0159\u00edda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rn\u00ed heptapeptid s C-termin\u00e1ln\u00edm Pro-Gly-Pro motivem<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1\u0159<\/strong><\/td>\n<td>Peptidov\u00fd roztok v uzav\u0159en\u00e9 lahvi\u010dce s uz\u00e1v\u011brem<\/td>\n<\/tr>\n<tr>\n<td><strong>Obsah peptid\u016f<\/strong><\/td>\n<td>10 mg nebo 30 mg na lahvi\u010dku<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td>Chlazen\u00e9 p\u0159i 2\u20138 \u00b0C, tmav\u00e9, uzav\u0159en\u00e9 a ve svisl\u00e9 poloze<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Materi\u00e1l se dod\u00e1v\u00e1 jako \u010dir\u00fd, bezbarv\u00fd peptidov\u00fd roztok v uzav\u0159en\u00e9 lahvi\u010dce s uzav\u00edrateln\u00fdm uz\u00e1v\u011brem. Vodn\u00fd roztok je citliv\u011bj\u0161\u00ed na sv\u011btlo, teplo a opakovan\u00e9 zm\u011bny teploty ne\u017e lyofilizovan\u00fd vzorek: kr\u00e1tk\u00e9 \u0159et\u011bzce se mohou ve vodn\u00e9m prost\u0159ed\u00ed pomalu hydrolyzovat a u z\u00e1sadit\u00e9ho \u0159et\u011bzce se profil n\u00e1boje nav\u00edc m\u011bn\u00ed s pH m\u00e9dia. Lahvi\u010dka proto z\u016fst\u00e1v\u00e1 uzav\u0159en\u00e1 v p\u016fvodn\u00edm obalu, dokud nen\u00ed vzorek zpracov\u00e1n v laborato\u0159i.<\/p>\n<p>Lahvi\u010dku skladujte v chladni\u010dce p\u0159i teplot\u011b 2\u20138 \u00b0C, na tmav\u00e9m m\u00edst\u011b a ve svisl\u00e9 poloze, aby se povrch kapaliny nedostal do kontaktu s uz\u00e1v\u011brem. Plat\u00ed obvykl\u00e1 laboratorn\u00ed opat\u0159en\u00ed: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, vyvarujte se del\u0161\u00edho vystaven\u00ed sv\u011btlu a okoln\u00ed teplot\u011b a zaznamenejte \u010d\u00edslo \u0161ar\u017ee a datum otev\u0159en\u00ed ka\u017ed\u00e9 lahvi\u010dky do laboratorn\u00edho den\u00edku, aby s\u00e9rie m\u011b\u0159en\u00ed z\u016fstala n\u00e1sledn\u011b sledovateln\u00e1.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>V komparativn\u00ed anal\u00fdze peptid\u016f ur\u010duje \u010distota v\u00fdchoz\u00ed l\u00e1tky, jak spolehliv\u011b lze interpretovat v\u00fdsledky m\u011b\u0159en\u00ed: zkr\u00e1cen\u00e9 varianty, dele\u010dn\u00ed sekvence a degrada\u010dn\u00ed fragmenty produkuj\u00ed dal\u0161\u00ed chromatografick\u00e9 p\u00edky, kter\u00e9 se mohou shodovat s hlavn\u00ed slo\u017ekou, a v p\u0159\u00edpad\u011b \u0159et\u011bzce bez aromatick\u00e9ho chromoforu je toto ov\u011b\u0159en\u00ed obzvl\u00e1\u0161t\u011b pracn\u00e9. N\u00e1\u0161 Selank se dod\u00e1v\u00e1 s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v souladu s p\u0159ilo\u017een\u00fdm analytick\u00fdm certifik\u00e1tem. Dostupn\u00e9 analytick\u00e9 certifik\u00e1ty si m\u016f\u017eete prohl\u00e9dnout na na\u0161ich webov\u00fdch str\u00e1nk\u00e1ch. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<h2>D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed<\/h2>\n<p>Tento produkt dod\u00e1v\u00e1me v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum a analytick\u00e9 pr\u00e1ce. Nen\u00ed ur\u010den pro diagnostick\u00e9 ani terapeutick\u00e9 aplikace a v\u00fdslovn\u011b nen\u00ed ur\u010den k pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Tento produkt nen\u00ed potravinou, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani registrovan\u00fdm l\u00e9\u010div\u00fdm p\u0159\u00edpravkem. Zakoupen\u00edm tohoto produktu kupuj\u00edc\u00ed potvrzuje, \u017ee je star\u0161\u00ed 18 let a bude jej pou\u017e\u00edvat v\u00fdhradn\u011b v kontrolovan\u00e9m v\u00fdzkumn\u00e9m nebo laboratorn\u00edm prost\u0159ed\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Selank je syntetick\u00fd line\u00e1rn\u00ed heptapeptid (C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub>, p\u0159ibli\u017en\u011b 751,9 g\/mol) se t\u0159emi prolinov\u00fdmi zbytky a C-termin\u00e1ln\u00edm motivem Pro-Gly-Pro, kter\u00fd \u010din\u00ed konec \u0159et\u011bzce rigidn\u00ed. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina v peptidov\u00e9 chemii a analytick\u00fdch prac\u00edch; tato verze je dod\u00e1v\u00e1na jako peptidov\u00fd roztok v uzav\u0159en\u00e9 lahvi\u010dce. Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nen\u00ed ur\u010deno pro pou\u017eit\u00ed u lid\u00ed ani zv\u00ed\u0159at. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3090,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[133,131],"product_tag":[],"class_list":["post-2810","product","type-product","status-publish","has-post-thumbnail","product_cat-focus-cognitie","product_cat-neussprays","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2810"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2810\/revisions"}],"predecessor-version":[{"id":2890,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2810\/revisions\/2890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3090"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2810"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2810"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2810"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}