{"id":2804,"date":"2026-09-01T09:28:00","date_gmt":"2026-09-01T09:28:00","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2804"},"modified":"2026-09-02T12:18:33","modified_gmt":"2026-09-02T12:18:33","slug":"vip-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/vip-10mg\/","title":{"rendered":"VIP 10 mg"},"content":{"rendered":"<h2>Co je VIP?<\/h2>\n<p>VIP je syntetick\u00fd line\u00e1rn\u00ed polypeptid slo\u017een\u00fd z dvaceti osmi aminokyselinov\u00fdch zbytk\u016f se sekvenc\u00ed His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn. Slou\u010denina m\u00e1 \u010d\u00edslo CAS 37221-79-7 a molekul\u00e1rn\u00ed vzorec C.<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S a molekulovou hmotnost\u00ed p\u0159ibli\u017en\u011b 3326,8 Da (PubChem CID 53314964).<\/p>\n<p>\u0158et\u011bzec kombinuje kysel\u00fd N-termin\u00e1ln\u00ed segment se dv\u011bma aspart\u00e1tov\u00fdmi zbytky a v\u00fdrazn\u011b bazickou st\u0159edn\u00ed \u010d\u00e1st\u00ed obsahuj\u00edc\u00ed dva argininov\u00e9 a t\u0159i lysinov\u00e9 zbytky; v cel\u00e9 sekvenci to vede k \u010dist\u00e9 bazick\u00e9 povaze a vysok\u00e9mu izoelektrick\u00e9mu bodu. Jeden methioninov\u00fd zbytek tvo\u0159\u00ed jedin\u00fd bod obsahuj\u00edc\u00ed s\u00edru, a proto citliv\u00fd na oxidaci, zat\u00edmco fenylalanin a dva tyrosinov\u00e9 zbytky zaji\u0161\u0165uj\u00ed UV absorpci. V roztoku molekula zauj\u00edm\u00e1 \u03b1-helixovou konformaci na velk\u00e9 \u010d\u00e1sti \u0159et\u011bzce, p\u0159i\u010dem\u017e nepol\u00e1rn\u00ed zbytky se seskupuj\u00ed na jedn\u00e9 stran\u011b helixu: amfipatick\u00fd vzor, \u200b\u200bkter\u00fd \u010d\u00e1ste\u010dn\u011b ur\u010duje jej\u00ed chov\u00e1n\u00ed na hydrofobn\u00edch povr\u0161\u00edch a retenci v chromatografii s reverzn\u00ed f\u00e1z\u00ed. Tato kombinace d\u00e9lky \u0159et\u011bzce, distribuce n\u00e1boje a v\u00fdrazn\u00e9 tvorby helixu \u010din\u00ed z VIP \u0161iroce pou\u017e\u00edvanou modelovou slou\u010deninu v konforma\u010dn\u00edm a strukturn\u00edm v\u00fdzkumu peptid\u016f st\u0159edn\u00ed d\u00e9lky.<\/p>\n<h2>Aplikace v laboratorn\u00edm kontextu<\/h2>\n<p>V r\u00e1mci peptidov\u00e9 chemie a analytick\u00e9 pr\u00e1ce se VIP vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdzkum vztahu struktura-aktivita<\/strong> ve kter\u00fdch jsou jednotliv\u00e9 zbytky substituov\u00e1ny, aby se charakterizoval jejich p\u0159\u00edsp\u011bvek ke stabilit\u011b helixu, distribuci n\u00e1boje a amfipatii.<\/li>\n<li><strong>V\u00fdzkum peptidov\u00e9 chemie<\/strong> sm\u011brem k rozpustnosti, agregaci a tvorb\u011b helixu amfipatick\u00fdch \u0159et\u011bzc\u016f, stanoven\u00edm konformace pomoc\u00ed cirkul\u00e1rn\u00edho dichroismu a NMR spektroskopie ve vodn\u00e9m a helix indukuj\u00edc\u00edm prost\u0159ed\u00ed, jako je trifluorethanol.<\/li>\n<li><strong>Studie enzymatick\u00e9 stability<\/strong> ve kter\u00e9m je degradace endo- a exopeptid\u00e1zami sledov\u00e1na v definovan\u00fdch pufrovac\u00edch syst\u00e9mech; spir\u00e1lov\u00e9 segmenty a flexibiln\u00ed konce se jasn\u011b li\u0161\u00ed v jejich p\u0159\u00edstupnosti pro enzymy.<\/li>\n<li><strong>V\u00fdvoj a validace analytick\u00fdch metod<\/strong> (HPLC, LC-MS, anal\u00fdza aminokyselin, mapov\u00e1n\u00ed peptid\u016f), kde VIP slou\u017e\u00ed jako referen\u010dn\u00ed standard pro dlouh\u00e9 syntetick\u00e9 \u0159et\u011bzce, v\u010detn\u011b p\u0159i\u0159azen\u00ed dele\u010dn\u00edch sekvenc\u00ed a oxida\u010dn\u00edch produkt\u016f methioninov\u00e9ho zbytku.<\/li>\n<\/ul>\n<h2>Specifikace<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Ochutnat<\/strong><\/td>\n<td>VIP<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u00e9lka peptidu<\/strong><\/td>\n<td>28 aminokyselinov\u00fdch zbytk\u016f<\/td>\n<\/tr>\n<tr>\n<td><strong>Sekvence<\/strong><\/td>\n<td>His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>37221-79-7<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/strong><\/td>\n<td>C<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S \/ cca 3326,8 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u0159\u00edda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rn\u00ed polypeptid (28 zbytk\u016f), v roztoku p\u0159ev\u00e1\u017en\u011b \u03b1-helik\u00e1ln\u00ed<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1\u0159<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce, 10 mg<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td>Lyofilizov\u00e1no p\u0159i 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Materi\u00e1l se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce s septem a smr\u0161\u0165ovac\u00edm uz\u00e1v\u011brem v mno\u017estv\u00ed 10 mg. Proces lyofilizace zachov\u00e1v\u00e1 molekul\u00e1rn\u00ed integritu \u0159et\u011bzce b\u011bhem skladov\u00e1n\u00ed a p\u0159epravy. Lyofiliz\u00e1t je b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd a m\u00e1 formu kompaktn\u00edho kol\u00e1\u010de nebo sypk\u00e9ho pr\u00e1\u0161ku; oboj\u00ed je norm\u00e1ln\u00ed vzhled. Materi\u00e1l je hygroskopick\u00fd a z\u016fst\u00e1v\u00e1 uzav\u0159en\u00fd v p\u016fvodn\u00edm obalu a\u017e do zpracov\u00e1n\u00ed v laborato\u0159i.<\/p>\n<p>Store the unopened lyophilized lyophilized powder refrigerated at 2\u20138 \u00b0C, in a dry and dark place, protected from light and moisture; for longer storage periods, it is usually stored frozen. Allow the vial to reach room temperature before opening to minimize condensation, work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other laboratory materials. Dispose of residual material in accordance with applicable laboratory guidelines.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>Pro \u0159et\u011bzec s dvaceti osmi zbytky jsou ur\u010duj\u00edc\u00edmi parametry identita a \u010distota: dele\u010dn\u00ed sekvence, ne\u00fapln\u011b \u0161t\u011bpen\u00e9 ochrann\u00e9 l\u00e1tky a oxidace methioninu jsou chromatograficky bl\u00edzk\u00e9 c\u00edlov\u00e9 slou\u010denin\u011b a mohou ovlivnit interpretaci v\u00fdsledk\u016f m\u011b\u0159en\u00ed. N\u00e1\u0161 VIP je dod\u00e1v\u00e1n s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v souladu s odpov\u00eddaj\u00edc\u00edm analytick\u00fdm certifik\u00e1tem. Dostupn\u00e9 analytick\u00e9 certifik\u00e1ty si m\u016f\u017eete prohl\u00e9dnout na na\u0161ich webov\u00fdch str\u00e1nk\u00e1ch. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<h2>D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed<\/h2>\n<p>Tento produkt dod\u00e1v\u00e1me v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum a analytick\u00e9 pr\u00e1ce. Nen\u00ed ur\u010den pro diagnostick\u00e9 ani terapeutick\u00e9 aplikace a v\u00fdslovn\u011b nen\u00ed ur\u010den k pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Tento produkt nen\u00ed potravinou, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani registrovan\u00fdm l\u00e9\u010div\u00fdm p\u0159\u00edpravkem. Zakoupen\u00edm tohoto produktu kupuj\u00edc\u00ed potvrzuje, \u017ee je star\u0161\u00ed 18 let a bude jej pou\u017e\u00edvat v\u00fdhradn\u011b v kontrolovan\u00e9m v\u00fdzkumn\u00e9m nebo laboratorn\u00edm prost\u0159ed\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>VIP je syntetick\u00fd line\u00e1rn\u00ed polypeptid o dvaceti osmi aminokyselinov\u00fdch zbytkech (C<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S, p\u0159ibli\u017en\u011b 3326,8 g\/mol), kter\u00e1 v roztoku zauj\u00edm\u00e1 \u03b1-helik\u00e1ln\u00ed konformaci na velk\u00e9 \u010d\u00e1sti \u0159et\u011bzce. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je studov\u00e1na jako modelov\u00e1 slou\u010denina v peptidov\u00e9 chemii a analytick\u00fdch prac\u00edch. Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nikoli pro pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3264,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,121],"product_tag":[],"class_list":["post-2804","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2804"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2804\/revisions"}],"predecessor-version":[{"id":2884,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2804\/revisions\/2884"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3264"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2804"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2804"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2804"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}