{"id":2790,"date":"2026-09-01T09:27:04","date_gmt":"2026-09-01T09:27:04","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2790"},"modified":"2026-09-02T12:19:33","modified_gmt":"2026-09-02T12:19:33","slug":"gonadorelin-2mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/gonadorelin-2mg\/","title":{"rendered":"Gonadorelin 2 mg"},"content":{"rendered":"<p>Gonadorelin je syntetick\u00fd dekapeptid, chemicky bitermin\u00e1ln\u011b modifikovan\u00fd peptid s pyroglutamylov\u00fdm za\u010d\u00e1tkem a C-termin\u00e1ln\u00edm glycinamidem. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro chemii receptorov\u011b v\u00e1zan\u00fdch peptid\u016f a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 2 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je Gonadorelin?<\/h2>\n<p>Gonadorelin je syntetick\u00e1 forma hormonu uvol\u0148uj\u00edc\u00edho gonadotropin (GnRH, ozna\u010dovan\u00e9ho tak\u00e9 jako LHRH) a skl\u00e1d\u00e1 se z deseti aminokyselin v sekvenci pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH.<sub>2<\/sub>Oba konce jsou chemicky unik\u00e1tn\u00ed. Na N-konci nen\u00ed \u017e\u00e1dn\u00fd voln\u00fd amin, ale pyroglutamov\u00e1 kyselina: intramolekul\u00e1rn\u011b cyklizovan\u00fd glutamin, ve kter\u00e9m je aminoskupina za\u010dlen\u011bna do laktamov\u00e9ho kruhu. Na C-konci nen\u00ed \u017e\u00e1dn\u00fd voln\u00fd karboxyl\u00e1t, ale glycinamid. Oba konce jsou proto elektricky neutralizov\u00e1ny, co\u017e znamen\u00e1, \u017ee celkov\u00fd n\u00e1boj je ur\u010den v\u00fdhradn\u011b postrann\u00edmi \u0159et\u011bzci, v praxi prim\u00e1rn\u011b argininem v poloze 8 a histidinem v poloze 2. Tato neutralizace n\u00e1boje sou\u010dasn\u011b sni\u017euje vazebn\u00e1 m\u00edsta pro amino- a karboxypeptid\u00e1zy.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech se gonadorelin pou\u017e\u00edv\u00e1 jako referen\u010dn\u00ed ligand pro receptor GnRH, receptor sp\u0159a\u017een\u00fd s G-proteinem t\u0159\u00eddy A. Proto\u017ee tento peptid je nejl\u00e9pe charakterizovan\u00fdm ligandem pro tento receptor, slou\u017e\u00ed jako referen\u010dn\u00ed bod ve vazebn\u00fdch studi\u00edch s vyu\u017eit\u00edm syst\u00e9m\u016f bun\u011b\u010dn\u00fdch kultur hypof\u00fdzy a membr\u00e1nov\u00fdch prepar\u00e1t\u016f p\u0159i porovn\u00e1v\u00e1n\u00ed modifikovan\u00fdch analog\u016f. Strukturn\u00ed v\u00fdzkum se zam\u011b\u0159uje na konformaci ve vazebn\u00e9 dr\u00e1\u017ece: glycin v poloze 6 umo\u017e\u0148uje t\u011bsn\u00fd ohyb. In vitro je peptid tak\u00e9 preferovan\u00fdm substr\u00e1tem pro enzymologick\u00e9 pr\u00e1ce, proto\u017ee k degradaci doch\u00e1z\u00ed selektivn\u011b mezi glycinem-6 a leucinem-7 a mezi prolinem-9 a glycinamidem. V d\u016fsledku toho se gonadorelin pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se Gonadorelin vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>V\u00fdzkum receptor\u016f GnRH jako receptoru sp\u0159a\u017een\u00e9m s G-proteinem t\u0159\u00eddy A s gonadorelinem jako referen\u010dn\u00edm ligandem ve vazebn\u00fdch testech.<\/li>\n<li>Enzymologick\u00fd v\u00fdzkum selektivn\u00edho \u0161t\u011bpen\u00ed peptid\u016f neutr\u00e1ln\u00edmi endopeptid\u00e1zami a enzymy \u0161t\u011bp\u00edc\u00edmi po prolinu.<\/li>\n<li>Studie vztahu struktury a aktivity na dekapeptidov\u00fdch analogech, ve kter\u00fdch jsou pozice 6 a 10 systematicky m\u011bn\u011bny.<\/li>\n<li>Biofyzik\u00e1ln\u00ed konforma\u010dn\u00ed anal\u00fdza (CD spektroskopie, NMR, molekul\u00e1rn\u00ed modelov\u00e1n\u00ed) k\u0159ivky kolem glycinu v poloze 6.<\/li>\n<li>V\u00fdvoj a validace analytick\u00e9 metody (HPLC s reverzn\u00ed f\u00e1z\u00ed, LC-MS) s gonadorelinem jako referen\u010dn\u00edm peptidov\u00fdm standardem.<\/li>\n<li>Studie stability oxidace tryptofanu a cyklizovan\u00fdch peptidov\u00fdch konc\u016f.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Gonadorelin v na\u0161em v\u00fdzkumn\u00e9m sortimentu<\/h2>\n<p>Gonadorelin spad\u00e1 v na\u0161\u00ed produktov\u00e9 \u0159ad\u011b do kategorie lyofilizovan\u00fdch experiment\u00e1ln\u00edch slou\u010denin ve form\u011b lahvi\u010dek. Zat\u00edmco se Gonadorelin zam\u011b\u0159uje na receptor sp\u0159a\u017een\u00fd s G-proteinem a vliv termin\u00e1ln\u00edch modifikac\u00ed, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly enzymatick\u00e9 nebo kovem koordinovan\u00e9 c\u00edle. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>Gonadorelin<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>gonadotropin uvol\u0148uj\u00edc\u00ed hormon (GnRH); LHRH; luliberin<\/td>\n<\/tr>\n<tr>\n<td>Sekvence<\/td>\n<td>pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>33515-09-2<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>55<\/sub>H<sub>75<\/sub>N<sub>17<\/sub>O<sub>13<\/sub> \/ 1182,29 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>638793<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Dekapeptid; amidovan\u00fd na C-konci, cyklizovan\u00fd na N-konci<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>2 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Gonadorelin se dod\u00e1v\u00e1 jako b\u00edl\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 2 mg na lahvi\u010dku, uzav\u0159en\u00fd pry\u017eovou z\u00e1tkou s hlin\u00edkov\u00fdm uz\u00e1v\u011brem. P\u0159i tomto mal\u00e9m mno\u017estv\u00ed je lyofiliz\u00e1t \u010dasto sotva viditeln\u00fd jako tenk\u00e1 vrstva na dn\u011b, co\u017e je v miligramov\u00e9m rozmez\u00ed norm\u00e1ln\u00ed. V laboratorn\u00edm prost\u0159ed\u00ed se materi\u00e1l d\u00e1le zpracov\u00e1v\u00e1 podle p\u0159\u00edslu\u0161n\u00e9ho analytick\u00e9ho protokolu.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe v p\u016fvodn\u00edm obalu. Tryptofan v poloze 3 je fotosenzitivn\u00ed a oxidovateln\u00fd, co\u017e \u010din\u00ed ochranu p\u0159ed sv\u011btlem a kysl\u00edkem pro tento peptid obzvl\u00e1\u0161t\u011b d\u016fle\u017eitou. Se slou\u010deninou zach\u00e1zejte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Lyofiliz\u00e1t obsahuje 2 mg gonadorelinu na lahvi\u010dku s kontrolovanou \u010distotou \u2265 99 % (HPLC). Nejsou p\u0159id\u00e1na \u017e\u00e1dn\u00e1 plnidla ani stabiliz\u00e1tory, tak\u017ee oxida\u010dn\u00ed produkty lze p\u0159ipsat \u010dist\u011b samotn\u00e9mu vzorku.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>, kde jsou zpr\u00e1vy centr\u00e1ln\u011b shroma\u017e\u010fov\u00e1ny.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed Gonadorelin?<\/strong><br \/>Dekapeptid a syntetick\u00fd prot\u011bj\u0161ek gonadotropin uvol\u0148uj\u00edc\u00edho hormonu (GnRH) s cyklizovan\u00fdm N-koncem a amidovan\u00fdm C-koncem.<\/p>\n<p><strong>Pro\u010d jsou oba konce chemicky odli\u0161n\u00e9?<\/strong><br \/>Kyselina pyroglutamov\u00e1 a glycinamid neobsahuj\u00ed \u017e\u00e1dnou volnou aminoskupinu ani voln\u00fd karboxyl\u00e1t. Oba konce jsou proto n\u00e1bojov\u011b neutr\u00e1ln\u00ed, co\u017e omezuje vazebn\u00e1 m\u00edsta pro amino- a karboxypeptid\u00e1zy.<\/p>\n<p><strong>V jak\u00e9 form\u011b je dod\u00e1v\u00e1no p\u0159ipojen\u00ed?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 2 mg v uzav\u0159en\u00e9 lahvi\u010dce, bez p\u0159idan\u00fdch pomocn\u00fdch l\u00e1tek.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladni\u010dce a temnu, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed, nejl\u00e9pe neotev\u0159en\u00e9 v p\u016fvodn\u00edm obalu.<\/p>","protected":false},"excerpt":{"rendered":"<p class=\"my-2 [&#038;+p]:mt-4 [&#038;_strong:has(+br)]:inline-block [&#038;_strong:has(+br)]:pb-2\"><strong data-start=\"790\" data-end=\"843\">Gonadorelin \u2013 Peptide voor Onderzoekstoepassingen<\/strong><br data-start=\"843\" data-end=\"846\" \/>Gonadorelin is een synthetisch decapeptide dat qua structuur overeenkomt met een endogeen hormoongerelateerd peptide. Het wordt in laboratoria gebruikt voor preklinische studies waarin de nadruk ligt op receptorbinding, peptideconfiguratie en moleculaire signaalroutes onder gecontroleerde omstandigheden.<\/p>\n","protected":false},"featured_media":3271,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[119,121],"product_tag":[],"class_list":["post-2790","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2790"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2790\/revisions"}],"predecessor-version":[{"id":2870,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2790\/revisions\/2870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3271"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2790"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2790"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2790"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}