{"id":2788,"date":"2026-09-01T09:27:04","date_gmt":"2026-09-01T09:27:04","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2788"},"modified":"2026-09-02T12:17:13","modified_gmt":"2026-09-02T12:17:13","slug":"oxytocin-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/oxytocin-vial-10-mg\/","title":{"rendered":"Oxytocin lahvi\u010dka 10 mg"},"content":{"rendered":"<p>Oxytocin je endogenn\u00ed nonapeptid pat\u0159\u00edc\u00ed do rodiny neurohypofyze\u00e1ln\u00edch peptidov\u00fdch hormon\u016f; chemicky se jedn\u00e1 o cyklick\u00fd peptid s intramolekul\u00e1rn\u00edm disulfidov\u00fdm m\u016fstkem. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro receptorovou farmakologii a peptidovou chemii a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg na lahvi\u010dku, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je oxytocin?<\/h2>\n<p>Oxytocin je peptid slo\u017een\u00fd z dev\u00edti aminokyselin se sekvenc\u00ed Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH.<sub>2<\/sub>Cysteinov\u00e9 zbytky v pozic\u00edch 1 a 6 tvo\u0159\u00ed disulfidov\u00fd m\u016fstek, co\u017e zp\u016fsobuje, \u017ee molekula nese uzav\u0159en\u00fd kruh \u0161esti aminokyselin s koncem o t\u0159ech zbytkech a amidovan\u00fdm C-koncem. Tato kombinace pevn\u00e9ho kruhu a flexibiln\u00edho konce \u010din\u00ed ze slou\u010deniny \u0161iroce pou\u017e\u00edvan\u00fd model p\u0159i studiu rozpozn\u00e1v\u00e1n\u00ed peptidov\u00fdch receptor\u016f.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech se oxytocin v\u00e1\u017ee na oxytocinov\u00fd receptor (OXTR), co\u017e je receptor t\u0159\u00eddy A podobn\u00fd rodopsinu se sedmi transmembr\u00e1nov\u00fdmi dom\u00e9nami. In vitro se tento receptor prim\u00e1rn\u011b v\u00e1\u017ee na G proteiny G1.<sub>q\/11<\/sub>-typ, po kter\u00e9m fosfolip\u00e1za C tvo\u0159\u00ed membr\u00e1nov\u00fd lipid PIP<sub>2<\/sub> \u0160t\u011bp\u00ed se na inositoltrifosf\u00e1t a diacylglycerol; prvn\u00ed z nich iniciuje uvol\u0148ov\u00e1n\u00ed intracelul\u00e1rn\u00edho v\u00e1pn\u00edku v bun\u011b\u010dn\u00fdch modelech, zat\u00edmco druh\u00fd aktivuje proteinkin\u00e1zu C. Proto\u017ee se oxytocin li\u0161\u00ed od p\u0159\u00edbuzn\u00fdch nonapeptid\u016f stejn\u00e9 hormon\u00e1ln\u00ed rodiny pouze ve dvou pozic\u00edch, vykazuje tak\u00e9 slab\u0161\u00ed zk\u0159\u00ed\u017eenou reaktivitu s p\u0159\u00edbuzn\u00fdmi receptorov\u00fdmi podtypy v bun\u011b\u010dn\u00fdch kultiva\u010dn\u00edch syst\u00e9mech. V d\u016fsledku toho se oxytocin pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se oxytocin vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Studie vazby oxytocinov\u00e9ho receptoru (OXTR) na receptory a afinita cyklick\u00fdch nonapeptid\u016f k \u200b\u200breceptor\u016fm t\u0159\u00eddy A in vitro.<\/li>\n<li>V\u00fdzkum G<sub>q\/11<\/sub>v\u00e1zan\u00e1 sign\u00e1ln\u00ed transdukce, aktivita fosfolip\u00e1zy C a mobilizace v\u00e1pn\u00edku v izolovan\u00fdch bun\u011b\u010dn\u00fdch modelech.<\/li>\n<li>Anal\u00fdza struktury a aktivity, ve kter\u00e9 se systematicky m\u011bn\u00ed disulfidace a jednotliv\u00e9 zbytky.<\/li>\n<li>Biofyzik\u00e1ln\u00ed modelov\u00e9 studie (NMR, cirkul\u00e1rn\u00ed dichroismus) prostorov\u00e9 struktury cyklick\u00fdch peptid\u016f.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS) s pou\u017eit\u00edm oxytocinu jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a rozpustnosti peptid\u016f obsahuj\u00edc\u00edch disulfidy za kontrolovan\u00fdch teplotn\u00edch a pH podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Oxytocin v na\u0161\u00ed v\u00fdzkumn\u00e9 \u0159ad\u011b<\/h2>\n<p>Oxytocin spad\u00e1 do kategorie lyofilizovan\u00fdch experiment\u00e1ln\u00edch peptid\u016f ve form\u011b lahvi\u010dek v na\u0161\u00ed nab\u00eddce. V\u00fdzkumn\u00edci v t\u00e9to kategorii pravideln\u011b kombinuj\u00ed tuto slou\u010deninu s jin\u00fdmi peptidy, kter\u00e9 jsou studov\u00e1ny prost\u0159ednictv\u00edm jejich vlastn\u00edho biochemick\u00e9ho c\u00edle. Zat\u00edmco Oxytocin c\u00edl\u00ed na receptor sp\u0159a\u017een\u00fd s G-proteinem t\u0159\u00eddy A, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly enzymatick\u00e9 nebo jin\u00e9 receptorem zprost\u0159edkovan\u00e9 c\u00edle. Tyto slou\u010deniny sd\u00edlej\u00ed lyofilizovanou formu lahvi\u010dek, ale z\u00e1sadn\u011b se li\u0161\u00ed slo\u017een\u00edm aminokyselin a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorek<\/td>\n<td>Oxytocin<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>a-hypofamin; ocytocin; Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH<sub>2<\/sub> (cyklick\u00fd p\u0159es disulfidov\u00fd m\u016fstek)<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>50-56-6<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub> \/ 1007,19 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>439302<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Cyklick\u00fd nonapeptid, neurohypofyz\u00e1rn\u00ed peptidov\u00fd hormon<\/td>\n<\/tr>\n<tr>\n<td>Forma<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m, such\u00e9m a tmav\u00e9m m\u00edst\u011b.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Oxytocin se dod\u00e1v\u00e1 ve form\u011b lyofilizovan\u00e9ho pr\u00e1\u0161ku v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce obsahuj\u00edc\u00ed standardizovan\u00e9 mno\u017estv\u00ed 10 mg. Na rozd\u00edl od pevn\u00e9 tablety se jedn\u00e1 o lyofilizovan\u00fd materi\u00e1l: pro analytick\u00e9 nebo bun\u011b\u010dn\u00e9 biologick\u00e9 pr\u00e1ce se materi\u00e1l rozpou\u0161t\u00ed ve vhodn\u00e9m rozpou\u0161t\u011bdle. Pr\u00e1\u0161ek je hygroskopick\u00fd a po vystaven\u00ed okoln\u00edmu vzduchu absorbuje vlhkost, co\u017e ovliv\u0148uje p\u0159esnost gravimetrick\u00fdch m\u011b\u0159en\u00ed.<\/p>\n<p>Uzav\u0159enou lahvi\u010dku skladujte na chladn\u00e9m a such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem, v p\u016fvodn\u00edm obalu; disulfidov\u00fd m\u016fstek je nejcitliv\u011bj\u0161\u00ed strukturou v molekule, proto je nutn\u00e9 minimalizovat oxida\u010dn\u00ed a tepeln\u00e9 stres. S l\u00e1tkou manipulujte se standardn\u00edmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>U tohoto lyofiliz\u00e1tu je zachov\u00e1na kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC). Lahvi\u010dka obsahuje peptid jako lyofilizovan\u00fd materi\u00e1l bez aktivn\u00edch vedlej\u0161\u00edch slo\u017eek.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy se shroma\u017e\u010fuj\u00ed centr\u00e1ln\u011b tam, abyste mohli data za\u010dlenit do vlastn\u00edch v\u00fdzkumn\u00fdch z\u00e1znam\u016f.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 skupiny l\u00e1tek pat\u0159\u00ed oxytocin?<\/strong><br \/>Oxytocin je cyklick\u00fd nonapeptid pat\u0159\u00edc\u00ed do rodiny neurohypofyz\u00e1rn\u00edch peptidov\u00fdch hormon\u016f. Skl\u00e1d\u00e1 se z dev\u00edti aminokyselin, kter\u00e9 jsou tvo\u0159eny disulfidov\u00fdm m\u016fstkem a tvo\u0159\u00ed kruhovou strukturu.<\/p>\n<p><strong>Jak\u00e1 je role disulfidov\u00e9ho m\u016fstku ve v\u00fdzkumu?<\/strong><br \/>M\u016fstek mezi cysteiny v pozic\u00edch 1 a 6 ur\u010duje konformaci a do zna\u010dn\u00e9 m\u00edry ur\u010duje rozpozn\u00e1n\u00ed receptorov\u00fdm proteinem in vitro. Jeho redukce nebo oxidace je proto opakovan\u00fdm t\u00e9matem studi\u00ed struktury, aktivity a stability.<\/p>\n<p><strong>V jak\u00e9 form\u011b je slou\u010denina dod\u00e1v\u00e1na?<\/strong><br \/>Jako lyofilizovan\u00fd pr\u00e1\u0161ek o hmotnosti 10 mg v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce.<\/p>\n<p><strong>Jak m\u00e1m skladovat lahvi\u010dku?<\/strong><br \/>Skladujte v chladu, suchu a chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem, nejl\u00e9pe v p\u016fvodn\u00edm obalu. I po rozpu\u0161t\u011bn\u00ed z\u016fst\u00e1v\u00e1 materi\u00e1l chladn\u00fd a tmav\u00fd.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong>Oxytocin<\/strong> je endogenn\u00ed cyklick\u00fd peptid o 9 aminokyselin\u00e1ch, kter\u00fd je produkov\u00e1n magnocelul\u00e1rn\u00edmi neurony paraventrikul\u00e1rn\u00edho a supraoptick\u00e9ho j\u00e1dra hypotalamu a uvol\u0148ov\u00e1n p\u0159es neurohypof\u00fdzu. V r\u00e1mci v\u00fdzkumu je zkoum\u00e1na role oxytocinu v soci\u00e1ln\u00edch vazb\u00e1ch, kontrakci hladk\u00e9ho svalstva a neuropeptidov\u00e9 signalizaci.<\/p>","protected":false},"featured_media":3251,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[119,121],"product_tag":[],"class_list":["post-2788","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2788"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2788\/revisions"}],"predecessor-version":[{"id":2864,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2788\/revisions\/2864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3251"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2788"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2788"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2788"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}