AHK-Cu Serum 35 ml is an aqueous research formulation based on a copper-binding tripeptide, chemically a metallopeptide of alanyl-L-histidyl-L-lysine with a coordinated copper(II) ion. In scientific research, this compound is studied as a model compound for the coordination chemistry of peptide-metal complexes and as a reference standard in analytical work. The product is offered as a ready-to-use aqueous formulation of 35 ml, exclusively for laboratory and research purposes.<\/p>\n
AHK-Cu is a synthetic tripeptide with the sequence alanine-histidine-lysine (Ala-His-Lys) to which one copper(II) ion is coordinated; in cosmetic nomenclature, the compound is known as copper tripeptide-3. The binding site for the metal ion is formed by three nitrogen donors that the chain presents in a planar arrangement: the \u03b1-amino group at the N-terminus, the amide nitrogen atom of the first peptide bond, and the imidazole of the histidine. The basic lysine side chain remains outside this arrangement and ensures good water solubility. What distinguishes AHK-Cu within this class of substances is one small structural difference: at the N-terminus, there is an alanine instead of the glycine that the most studied copper tripeptide carries there. That extra methyl group makes the compound a sharp model for the question of how a single substitution alongside the coordinating histidine affects copper affinity.<\/p>\n
In research models, the complex is primarily studied as a carrier and donor of copper: in vitro, under defined conditions, the coordinated ion can be transferred to competing ligands or to copper-dependent enzymes such as lysyl oxidase and superoxide dismutase. Additionally, the copper(II) center makes the formulation easy to monitor spectroscopically: alongside the UV absorption of the imidazole, a weak dd transition occurs in the visible region, which explains the bluish tint and makes the integrity of the complex measurable. In cell-free systems and cell culture models, copper homeostasis and VEGF-mediated signaling are further investigated. Consequently, AHK-Cu is used as a model compound and reference substance within scientific research.<\/p>\n
In a laboratory context, AHK-Cu occurs in the following research areas, among others:<\/p>\n
Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n
Within our range, this product falls under the category of ready-to-use aqueous investigational formulations in vial form. While this formulation focuses on metal coordination and the influence of a single amino acid substitution thereon, other components within the same product line have been specifically chosen to cover peptide receptor interactions or enzymatically mediated targets. These products share the aqueous serum base and vial packaging, but differ fundamentally in molecular class and investigated mechanism.<\/p>\n
| Specifikace<\/th>\n | Hodnota<\/th>\n<\/tr>\n<\/thead>\n | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ochutnat<\/td>\n | AHK-Cu (alanyl-L-histidyl-L-lysine, copper(II) complex)<\/td>\n<\/tr>\n | ||||||||||
| Synonyma<\/td>\n | copper tripeptide-3; Cu-AHK<\/td>\n<\/tr>\n | ||||||||||
| Sekvence<\/td>\n | Ala-His-Lys<\/td>\n<\/tr>\n | ||||||||||
| \u010c\u00edslo CAS<\/td>\n | 682809-81-0<\/td>\n<\/tr>\n | ||||||||||
| Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n | C15<\/sub>H24<\/sub>ClCuN6<\/sub>O4<\/sub> \/ 451.39 Da (monohydrochloride)<\/td>\n<\/tr>\n| PubChem CID<\/td>\n | 168431292<\/td>\n<\/tr>\n | T\u0159\u00edda<\/td>\n | Metalopeptid; m\u011b\u010fnat\u00fd(II) komplex tripeptidu<\/td>\n<\/tr>\n | Formul\u00e1\u0159<\/td>\n | Aqueous serum with preservative<\/td>\n<\/tr>\n | Contents per bottle<\/td>\n | 35 ml<\/td>\n<\/tr>\n | Skladov\u00e1n\u00ed<\/td>\n | Keep cool, protected from direct light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n | Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\nThe product is supplied as a ready-to-use aqueous formulation of 35 ml in a vial. No solid needs to be weighed: the active substance is already stabilized in the matrix, together with a preservative that inhibits microbial growth. The liquid has the bluish tint characteristic of copper(II) peptides, which comes from the coordinated metal ion. In a research setting, the formulation is applied to model substrates or cell culture preparations in accordance with the applicable laboratory protocol.<\/p>\n Store the vial in a cool, protected place away from direct light, and tightly closed when not in use. Copper(II) complexes are sensitive to light, heat, and oxidative conditions, more so in aqueous matrix than in dry form. Handle the product with standard laboratory precautions: work cleanly, use appropriate personal protective equipment, and prevent cross-contamination. Keep the packaging out of reach of unauthorized persons.<\/p>\n Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\nThe AHK-Cu active ingredient in this formulation is offered with a controlled purity of \u2265 99% (HPLC). That figure refers to the processed metallopeptide and not to the preparation as a whole; the exact active ingredient concentration is available upon request.<\/p>\n |