{"id":2767,"date":"2026-09-01T09:26:32","date_gmt":"2026-09-01T09:26:32","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2767"},"modified":"2026-09-02T16:56:08","modified_gmt":"2026-09-02T16:56:08","slug":"ghk-cu-en-snap-8-serum-35-ml","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/ghk-cu-en-snap-8-serum-35-ml\/","title":{"rendered":"S\u00e9rum GHK-Cu a SNAP-8 35 ml"},"content":{"rendered":"<p>S\u00e9rum GHK-Cu a SNAP-8 je dvouslo\u017ekov\u00e1 referen\u010dn\u00ed formulace syntetick\u00fdch peptid\u016f, chemicky kombinace komplexu m\u011b\u010fnat\u00e9ho(II) tripeptidu a acetylovan\u00e9ho, \u200b\u200bC-termin\u00e1ln\u011b amidovan\u00e9ho oktapeptidu. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je formulace studov\u00e1na jako v\u00edceslo\u017ekov\u00fd modelov\u00fd syst\u00e9m pro koordina\u010dn\u00ed chemii a stabilitu peptid\u016f a jako referen\u010dn\u00ed sm\u011bs v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako 35ml vodn\u00e1 formulace, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je s\u00e9rum GHK-Cu a SNAP-8?<\/h2>\n<p>Prvn\u00ed slo\u017ekou je glycyl-L-histidyl-L-lysin, koordinovan\u00fd s m\u011b\u010fnat\u00fdm(II) iontem. Tripeptid v\u00e1\u017ee kovov\u00fd iont prost\u0159ednictv\u00edm imidazolov\u00e9ho atomu dus\u00edku histidinov\u00e9ho zbytku, deprotonovan\u00e9ho amidov\u00e9ho dus\u00edku z hlavn\u00edho \u0159et\u011bzce a N-termin\u00e1ln\u00ed aminoskupiny, co\u017e vede k tetragon\u00e1ln\u011b zkreslen\u00e9mu koordina\u010dn\u00edmu vzoru ve \u010dtvercov\u00e9 rovin\u011b. Tato geometrie d\u00e1v\u00e1 komplexu absorp\u010dn\u00ed p\u00e1smo dd kolem 500\u2013600 nm a \u010din\u00ed ho vysoce spektroskopicky sledovateln\u00fdm. Druh\u00e1 slo\u017eka, SNAP-8, je oktapeptid s acetylovan\u00fdm N-koncem a amidovan\u00fdm C-koncem; ob\u011b modifikace neutralizuj\u00ed n\u00e1boje na konc\u00edch \u0159et\u011bzce, \u010d\u00edm\u017e sni\u017euj\u00ed celkov\u00fd n\u00e1boj a m\u011b\u0159iteln\u011b m\u011bn\u00ed reten\u010dn\u00ed chov\u00e1n\u00ed na kolon\u00e1ch s invertovanou f\u00e1z\u00ed.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech jsou slo\u017eky studov\u00e1ny z hlediska r\u016fzn\u00fdch bod\u016f p\u016fsoben\u00ed: komplex m\u011bdi jako model pro procesy z\u00e1visl\u00e9 na m\u011bdi a pro expresi slo\u017eek matrice ve fibroblastov\u00fdch bun\u011b\u010dn\u00fdch modelech a SNAP-8 jako strukturn\u00ed analog N-termin\u00e1ln\u00edho segmentu proteinu SNAP-25 ve v\u00fdzkumu tvorby komplex\u016f SNARE bez bun\u011bk. Proto\u017ee jsou ob\u011b l\u00e1tky p\u0159\u00edtomny ve stejn\u00e9 matrici, p\u0159edstavuje formulace sou\u010dasn\u011b v\u00edceslo\u017ekovou referen\u010dn\u00ed sm\u011bs: metoda, kter\u00e1 zobrazuje oba p\u00edky zcela odd\u011blen\u00e9, prokazuje, \u017ee rozli\u0161ovac\u00ed schopnost je dostate\u010dn\u00e1. V d\u016fsledku toho se tato formulace ve v\u011bdeck\u00e9m v\u00fdzkumu pou\u017e\u00edv\u00e1 jak jako modelov\u00e1 slou\u010denina, tak jako referen\u010dn\u00ed l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm prost\u0159ed\u00ed se s\u00e9rum GHK-Cu a SNAP-8 vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Studie koordina\u010dn\u00ed chemie vazebn\u00e9 geometrie m\u011bdi(II) na tripeptidy obsahuj\u00edc\u00ed histidin.<\/li>\n<li>V\u00fdvoj spektroskopick\u00e9 metody s komplexem m\u011bdi jako detek\u010dn\u00ed a kalibra\u010dn\u00ed referenc\u00ed ve viditeln\u00e9 oblasti.<\/li>\n<li>Studie struktury a aktivity zab\u00fdvaj\u00edc\u00ed se vlivem N-termin\u00e1ln\u00ed acetylace a C-termin\u00e1ln\u00ed amidace na distribuci n\u00e1boje a konformaci.<\/li>\n<li>V\u00fdzkum sestavov\u00e1n\u00ed SNARE komplex\u016f a kompetitivn\u00ed vazby peptid\u016f v bezbun\u011b\u010dn\u00fdch modelov\u00fdch syst\u00e9mech.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS) s formulac\u00ed jako v\u00edceslo\u017ekov\u00e1 referen\u010dn\u00ed sm\u011bs.<\/li>\n<li>Studie stability a rozpustnosti peptid\u016f a kovov\u00fdch komplex\u016f ve vodn\u00e9 matrici.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>S\u00e9rum GHK-Cu a SNAP-8 v na\u0161\u00ed v\u00fdzkumn\u00e9 \u0159ad\u011b<\/h2>\n<p>V r\u00e1mci na\u0161\u00ed \u0159ady spad\u00e1 tato formulace do kategorie topick\u00fdch v\u00fdzkumn\u00fdch formulac\u00ed: vodn\u00e9 matrice, ve kter\u00fdch jsou aktivn\u00ed slo\u017eky dod\u00e1v\u00e1ny ji\u017e rozpu\u0161t\u011bn\u00e9. Zat\u00edmco tato formulace kombinuje dv\u011b aktivn\u00ed slo\u017eky s r\u016fzn\u00fdmi body \u00fa\u010dinku, ostatn\u00ed slo\u017eky ve stejn\u00e9 \u0159ad\u011b obsahuj\u00ed bu\u010f jednu definovanou aktivn\u00ed slo\u017eku, nebo aktivn\u00ed slo\u017eku z jin\u00e9 molekul\u00e1rn\u00ed t\u0159\u00eddy. Sd\u00edlej\u00ed tekutou formu, ale li\u0161\u00ed se slo\u017een\u00edm a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>GHK-Cu a SNAP-8 s\u00e9rum, 35 ml<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>M\u011b\u010fnat\u00fd tripeptid-1; Acetylglutamyl oktapeptid-3<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>89030-95-5 (komplex m\u011bdi) \/ 49557-75-7 (voln\u00fd tripeptid); 868844-74-0<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>14<\/sub>H<sub>22<\/sub>CuN<sub>6<\/sub>O<sub>4<\/sub> \/ 401,91 Da; C<sub>41<\/sub>H<sub>70<\/sub>N<sub>16<\/sub>O<sub>16<\/sub>S \/ 1075,16 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>165429100 (komplex m\u011bdi)<\/td>\n<\/tr>\n<tr>\n<td>Sekvence<\/td>\n<td>Gly-His-Lys (+ Cu)<sup>2+<\/sup>); Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Komplex kovov\u00fdch peptid\u016f a modifikovan\u00fd syntetick\u00fd oktapeptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Vodn\u00e1 formulace s konzerva\u010dn\u00ed l\u00e1tkou<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na jednotku<\/td>\n<td>35 ml na lahvi\u010dku<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Skladujte v chladu p\u0159i teplot\u011b 2\u20138 \u00b0C, chra\u0148te p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>P\u0159\u00edpravek se dod\u00e1v\u00e1 jako \u010dir\u00e1 a\u017e sv\u011btle modr\u00e1 tekutina v 35ml lahvi\u010dce; barva je v\u00fdsledkem absorpce m\u011b\u010fnat\u00e9ho centra ligandov\u00fdm polem. Ob\u011b aktivn\u00ed slo\u017eky jsou ji\u017e rozpu\u0161t\u011bny, tak\u017ee p\u0159\u00edpravek lze pou\u017e\u00edt jako kapaln\u00fd vzorek bez p\u0159edchoz\u00ed \u00fapravy. P\u0159esn\u00e9 koncentrace jsou k dispozici na vy\u017e\u00e1d\u00e1n\u00ed.<\/p>\n<p>Lahvi\u010dku skladujte v chladu p\u0159i teplot\u011b 2\u20138 \u00b0C, chra\u0148te p\u0159ed sv\u011btlem a teplem a po ka\u017ed\u00e9m odb\u011bru ji uzav\u0159ete; vodn\u00e9 peptidov\u00e9 matrice jsou citliv\u00e9 na kol\u00eds\u00e1n\u00ed teploty a mikrobi\u00e1ln\u00ed kontaminaci. S p\u0159\u00edpravkem zach\u00e1zejte s obvykl\u00fdmi laboratorn\u00edmi opat\u0159en\u00edmi: \u010dist\u00e9 prost\u0159ed\u00ed, vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky, odb\u011br vzork\u016f \u010dist\u00fdm vybaven\u00edm a mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>Suroviny v t\u00e9to receptu\u0159e jsou v\u00fdzkumn\u00e9 kvality a nab\u00edzej\u00ed se s kontrolovanou \u010distotou \u2265 99 % (HPLC). U komplexu m\u011bdi je spektroskopick\u00fd profil ur\u010den stechiometrick\u00fdm pom\u011brem mezi tripeptidem a kovov\u00fdm iontem.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>, kde jsou zpr\u00e1vy centr\u00e1ln\u011b shroma\u017e\u010fov\u00e1ny.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed ob\u011b slo\u017eky?<\/strong><br \/>Prvn\u00edm je komplex kov-peptid: tripeptid, kter\u00fd koordinuje iont m\u011bdi(II). Druh\u00fdm je syntetick\u00fd oktapeptid s acetylovan\u00fdm N-koncem a amidovan\u00fdm C-koncem.<\/p>\n<p><strong>Pro\u010d je koordina\u010dn\u00ed geometrie relevantn\u00ed?<\/strong><br \/>Okol\u00ed iontu m\u011bdi(II) ur\u010duje energii dd p\u0159echod\u016f a t\u00edm i absorp\u010dn\u00ed p\u00e1smo kolem 500\u2013600 nm; toto p\u00e1smo je p\u0159\u00edm\u00fdm indik\u00e1torem integrity koordinace.<\/p>\n<p><strong>V jak\u00e9 form\u011b je p\u0159\u00edpravek dod\u00e1v\u00e1n?<\/strong><br \/>Jako vodn\u00e1 formulace o objemu 35 ml s konzerva\u010dn\u00ed l\u00e1tkou, ve kter\u00e9 jsou ob\u011b \u00fa\u010dinn\u00e9 l\u00e1tky ji\u017e p\u0159\u00edtomny v rozpu\u0161t\u011bn\u00e9 form\u011b.<\/p>\n<p><strong>Jak ulo\u017e\u00edm formulaci?<\/strong><br \/>Uchov\u00e1vejte v chladu p\u0159i teplot\u011b 2\u20138 \u00b0C, chra\u0148te p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem a teplem, s pevn\u011b uzav\u0159enou lahv\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Topick\u00e9 experiment\u00e1ln\u00ed s\u00e9rum, kter\u00e9 kombinuje dva komplement\u00e1rn\u00ed experiment\u00e1ln\u00ed peptidy: <strong>GHK-Cu<\/strong> (komplex glycyl-L-histidyl-L-lysin + m\u011b\u010f) pro modely extracelul\u00e1rn\u00ed matrix a <strong>SNAP-8<\/strong> (Acetyl Glutamyl Octapeptid-3) pro v\u00fdzkum komplexu SNARE. Tato kombinace je studov\u00e1na v r\u00e1mci v\u00fdzkumu soub\u011b\u017en\u00fdch \u00fa\u010dink\u016f na modely kolagenu\/elastinu a signalizaci bun\u011bk mimick\u00e9ho svalstva.<\/p>","protected":false},"featured_media":3333,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[136],"product_tag":[],"class_list":["post-2767","product","type-product","status-publish","has-post-thumbnail","product_cat-topicals","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2767"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2767\/revisions"}],"predecessor-version":[{"id":2831,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2767\/revisions\/2831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3333"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2767"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2767"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2767"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}