{"id":2628,"date":"2026-09-01T09:15:58","date_gmt":"2026-09-01T09:15:58","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2628"},"modified":"2026-09-02T12:17:09","modified_gmt":"2026-09-02T12:17:09","slug":"b12-10ml-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/b12-10ml-10mg\/","title":{"rendered":"B12 10ml\/10mg"},"content":{"rendered":"<p>Vitamin B12 (kobalamin) je ve vod\u011b rozpustn\u00e1 kobaltovo-korinoidn\u00ed slou\u010denina, chemicky organokovov\u00fd komplex s centr\u00e1ln\u00edm kobaltov\u00fdm iontem v korinov\u00e9m kruhov\u00e9m syst\u00e9mu. Ve v\u011bdeck\u00e9m v\u00fdzkumu je studov\u00e1n jako modelov\u00e1 slou\u010denina pro enzymovou katal\u00fdzu v\u00e1zanou na kofaktory a jako referen\u010dn\u00ed standard v analytick\u00fdch prac\u00edch. Tato slou\u010denina je nab\u00edzena jako 10ml roztok p\u0159ipraven\u00fd k pou\u017eit\u00ed s \u200b\u200bobsahem 10 mg, v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>Co je vitam\u00edn B12 (kobalamin)?<\/h2>\n<p>Kobalamin je souhrnn\u00fd n\u00e1zev pro skupinu korinoid\u016f, z nich\u017e kyanokobalamin (C<sub>63<\/sub>H<sub>88<\/sub>O\u0161idit<sub>14<\/sub>O<sub>14<\/sub>P) je obecn\u011b uzn\u00e1vanou referen\u010dn\u00ed formou t\u00e9to t\u0159\u00eddy. Molekula se skl\u00e1d\u00e1 z korinov\u00e9ho kruhu se \u010dty\u0159mi pyrrolov\u00fdmi kruhy obsahuj\u00edc\u00edmi centr\u00e1ln\u00ed kobaltov\u00fd iont, nukleotidov\u00e9ho postrann\u00edho \u0159et\u011bzce s 5,6-dimethylbenzimidazolem jako ni\u017e\u0161\u00edm axi\u00e1ln\u00edm ligandem a zam\u011bniteln\u00e9ho horn\u00edho axi\u00e1ln\u00edho ligandu, kter\u00fd odli\u0161uje kobalaminov\u00e9 formy. Tato kombinace p\u0159echodn\u00e9ho kovu v makrocyklick\u00e9m prost\u0159ed\u00ed se zam\u011bnitelnou koordina\u010dn\u00ed pozic\u00ed \u010din\u00ed ze slou\u010deniny \u0161iroce pou\u017e\u00edvan\u00fd model v bioanorganick\u00e9 chemii.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech odvozuje kobalamin sv\u016fj v\u00fdznam p\u0159edev\u0161\u00edm z vazby kobalt-uhl\u00edk, jedin\u00e9 organokovov\u00e9 vazby popsan\u00e9 v biochemii \u017eiv\u00fdch syst\u00e9m\u016f. In vitro funguj\u00ed odvozen\u00e9 formy methylkobalamin a adenosylkobalamin jako kofaktory pro methionin synt\u00e1zu a methylmalonyl-CoA mut\u00e1zu \u2013 dva enzymy pou\u017e\u00edvan\u00e9 v bun\u011b\u010dn\u00fdch modelech ke studiu p\u0159enosu methylu a radik\u00e1lov\u011b zprost\u0159edkovan\u00fdch p\u0159esmyk\u016f. Vazba kobalt-uhl\u00edk je nav\u00edc fotosenzitivn\u00ed a m\u016f\u017ee b\u00fdt homolyticky \u0161t\u011bpena za kontrolovan\u00e9ho osv\u011btlen\u00ed, co\u017e \u010din\u00ed tuto slou\u010deninu vhodnou pro fotochemick\u00e9 a spektroskopick\u00e9 modelov\u00e1n\u00ed. V d\u016fsledku toho se vitamin B12 pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se vitam\u00edn B12 vyskytuje mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>Enzymologick\u00e9 vy\u0161et\u0159en\u00ed kobalamin-dependentn\u00edch methyltransfer\u00e1z a p\u0159enosu methylu prost\u0159ednictv\u00edm methionin synt\u00e1zy in vitro.<\/li>\n<li>Mechanistick\u00e9 studium radik\u00e1lov\u011b zprost\u0159edkovan\u00fdch p\u0159esmykov\u00fdch reakc\u00ed adenosylkobalamin-dependentn\u00edmi mut\u00e1zami v izolovan\u00fdch enzymov\u00fdch syst\u00e9mech.<\/li>\n<li>Bioanorganick\u00e9 a biofyzik\u00e1ln\u00ed modelov\u00e9 studie vazby kobalt-uhl\u00edk, v\u00fdm\u011bny ligand\u016f a koordina\u010dn\u00ed chemie korinoid\u016f.<\/li>\n<li>Molekul\u00e1rn\u011b biologick\u00fd v\u00fdzkum ribosp\u00edna\u010d\u016f v\u00e1zaj\u00edc\u00edch kobalamin a fotoreceptorov\u00fdch protein\u016f z\u00e1visl\u00fdch na kobalaminu v modelech mikrobi\u00e1ln\u00edch bun\u011bk.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, UV-Vis spektroskopie, LC-MS) s pou\u017eit\u00edm kobalaminu jako referen\u010dn\u00edho standardu.<\/li>\n<li>Studie stability a fotodegradace korinoid\u016f za kontrolovan\u00fdch podm\u00ednek.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Vitam\u00edn B12 v na\u0161\u00ed v\u00fdzkumn\u00e9 \u0159ad\u011b<\/h2>\n<p>Vitamin B12 spad\u00e1 do na\u0161\u00ed nab\u00eddky v tekut\u00fdch v\u00fdzkumn\u00fdch roztokech v lahvi\u010dk\u00e1ch p\u0159ipraven\u00fdch k pou\u017eit\u00ed, co\u017e je kategorie odli\u0161n\u00e1 od lyofilizovan\u00fdch pr\u00e1\u0161kov\u00fdch forem. Zat\u00edmco kobalamin se zam\u011b\u0159uje na chemii kofaktor\u016f v\u00e1zan\u00fdch na kovy a enzymovou katal\u00fdzu, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokr\u00fdvaly c\u00edle v\u00e1zan\u00e9 na receptory nebo sign\u00e1ln\u00ed transdukci. Tyto slou\u010deniny sd\u00edlej\u00ed tekutou formu, ale z\u00e1sadn\u011b se li\u0161\u00ed molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Ochutnat<\/td>\n<td>Vitam\u00edn B12 (kobalamin)<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>kyanokobalamin; kyanokobo(III)alamin; CN-Cbl \u2013 jako referen\u010dn\u00ed forma t\u0159\u00eddy kobalamin\u016f<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>68-19-9 (kyanokobalamin)<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n<td>C<sub>63<\/sub>H<sub>88<\/sub>O\u0161idit<sub>14<\/sub>O<sub>14<\/sub>P\/1355,4 Da (kyanokobalamin)<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>166596686 (kyanokobalamin)<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Ve vod\u011b rozpustn\u00e1 kobaltovo-korinoidn\u00ed slou\u010denina, nikoli peptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1\u0159<\/td>\n<td>Hotov\u00fd roztok v lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na jednotku<\/td>\n<td>10 mg v 10 ml<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Uchov\u00e1vejte v chladni\u010dce p\u0159i teplot\u011b 2\u20138 \u00b0C, na tmav\u00e9m m\u00edst\u011b a chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Vitamin B12 se dod\u00e1v\u00e1 jako vodn\u00fd roztok p\u0159ipraven\u00fd k pou\u017eit\u00ed v 10ml lahvi\u010dce obsahuj\u00edc\u00ed celkem 10 mg. Na rozd\u00edl od lyofilizovan\u00fdch slou\u010denin nen\u00ed u t\u00e9to formy nutn\u00e1 rekonstituce; roztok lze odebrat p\u0159\u00edmo z laboratorn\u00edho za\u0159\u00edzen\u00ed pro dal\u0161\u00ed anal\u00fdzu.<\/p>\n<p>Lahvi\u010dku skladujte v chladni\u010dce p\u0159i teplot\u011b 2\u20138 \u00b0C, na tmav\u00e9m m\u00edst\u011b a chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem, v p\u016fvodn\u00edm obalu; korinoidy jsou fotosenzitivn\u00ed, proto je u t\u00e9to t\u0159\u00eddy l\u00e1tek t\u0159eba v\u011bnovat zvl\u00e1\u0161tn\u00ed pozornost ochran\u011b p\u0159ed sv\u011btlem. Se slou\u010deninou zach\u00e1zejte s obvykl\u00fdmi laboratorn\u00edmi opat\u0159en\u00edmi: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky a zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly. Uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob.<\/p>\n<h2>Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n<p>V\u00fdchoz\u00ed materi\u00e1l pro tento roztok je vybr\u00e1n s kontrolovanou \u010distotou \u2265 99 % (HPLC). Obsah lahvi\u010dky je vyj\u00e1d\u0159en jako mno\u017estv\u00ed l\u00e1tky na jednotku: 10 mg v 10 ml.<\/p>\n<p>P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>Zpr\u00e1vy se shroma\u017e\u010fuj\u00ed centr\u00e1ln\u011b tam, abyste mohli data za\u010dlenit do vlastn\u00edch v\u00fdzkumn\u00fdch z\u00e1znam\u016f.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 skupiny l\u00e1tek pat\u0159\u00ed vitam\u00edn B12?<\/strong><br \/>Vitamin B12 je ve vod\u011b rozpustn\u00e1 kobalt-korinoidn\u00ed slou\u010denina: organokovov\u00fd komplex s kobaltov\u00fdm iontem v korinov\u00e9m kruhu. Nen\u00ed to peptid, a proto neobsahuje \u017e\u00e1dnou aminokyselinovou sekvenci.<\/p>\n<p><strong>Co d\u011bl\u00e1 vazbu kobalt-uhl\u00edk zaj\u00edmavou pro v\u00fdzkum?<\/strong><br \/>Je to jedin\u00e1 organokovov\u00e1 vazba popsan\u00e1 v \u017eiv\u00fdch syst\u00e9mech. Ve v\u00fdzkumn\u00fdch modelech je tato vazba homolyticky \u0161t\u011bpena za \u00fa\u010delem mechanistick\u00e9ho studia radik\u00e1lov\u00e9 chemie a fotol\u00fdzy korinoid\u016f.<\/p>\n<p><strong>Jak\u00fd je rozd\u00edl mezi r\u016fzn\u00fdmi formami kobalaminu?<\/strong><br \/>Formy se li\u0161\u00ed v nad\u0159azen\u00e9m axi\u00e1ln\u00edm ligandu p\u0159ipojen\u00e9m k kobaltov\u00e9mu iontu. Kyanokobalamin je pova\u017eov\u00e1n za referen\u010dn\u00ed formu t\u00e9to t\u0159\u00eddy; methylkobalamin a adenosylkobalamin p\u016fsob\u00ed in vitro jako enzymov\u00e9 kofaktory.<\/p>\n<p><strong>Jak ulo\u017e\u00edm \u0159e\u0161en\u00ed?<\/strong><br \/>Skladujte v chladni\u010dce p\u0159i teplot\u011b 2\u20138 \u00b0C, na tmav\u00e9m a chr\u00e1n\u011bn\u00e9m m\u00edst\u011b, nejl\u00e9pe v p\u016fvodn\u00edm obalu.<\/p>","protected":false},"excerpt":{"rendered":"<p>Vitamin B12 (kobalamin) je ve vod\u011b rozpustn\u00fd vitamin, kter\u00fd hraje roli v tvorb\u011b \u010derven\u00fdch krvinek a nervov\u00e9m syst\u00e9mu.<\/p>","protected":false},"featured_media":3249,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[135,120,121],"product_tag":[],"class_list":["post-2628","product","type-product","status-publish","has-post-thumbnail","product_cat-aanbevolen","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2628"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2628\/revisions"}],"predecessor-version":[{"id":2701,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2628\/revisions\/2701"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3249"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2628"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2628"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2628"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}