{"id":2609,"date":"2026-09-01T09:15:03","date_gmt":"2026-09-01T09:15:03","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2609"},"modified":"2026-09-02T12:23:38","modified_gmt":"2026-09-02T12:23:38","slug":"mazdutide-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/mazdutide-10mg\/","title":{"rendered":"Mazdutid 10 mg"},"content":{"rendered":"<h2>Co je Mazdutid?<\/h2>\n<p>Mazdutid je syntetick\u00fd acylovan\u00fd polypeptid: dlouh\u00fd \u0159et\u011bzec aminokyseliny, ke kter\u00e9mu je mastn\u00e1 kyselina s dlouh\u00fdm \u0159et\u011bzcem kovalentn\u011b v\u00e1z\u00e1na prost\u0159ednictv\u00edm linkeru na postrann\u00edm \u0159et\u011bzci lysinov\u00e9ho zbytku. Slou\u010denina je zn\u00e1m\u00e1 pod \u010d\u00edslem CAS 2259884-03-0, s molekul\u00e1rn\u00edm vzorcem C<sub>210<\/sub>H<sub>322<\/sub>N<sub>46<\/sub>O<sub>67<\/sub> a molekulovou hmotnost p\u0159ibli\u017en\u011b 4563 Da. To \u0159ad\u00ed molekulu do lipopeptid\u016f: peptidov\u00fdch \u0159et\u011bzc\u016f, kter\u00e9 nesou kovalentn\u011b v\u00e1zan\u00fd konec mastn\u00e9 kyseliny.<\/p>\n<p>Tato acylace je ur\u010duj\u00edc\u00edm strukturn\u00edm rysem a drasticky m\u011bn\u00ed fyzik\u00e1ln\u011b-chemick\u00fd profil \u0159et\u011bzce. Lipofiln\u00ed konec p\u0159ipojen\u00fd k jinak p\u0159ev\u00e1\u017en\u011b pol\u00e1rn\u00edmu \u0159et\u011bzci m\u011bn\u00ed rozpustnost ve vodn\u00e9m prost\u0159ed\u00ed, zvy\u0161uje tendenci k samovoln\u00e9 asociaci a agregaci se zvy\u0161uj\u00edc\u00ed se koncentrac\u00ed a zvy\u0161uje nekovalentn\u00ed vazbu na proteiny in vitro. Proto\u017ee je vazebn\u00e9 m\u00edsto na lysinov\u00e9m postrann\u00edm \u0159et\u011bzci chemicky definovan\u00e9, lze slou\u010deninu p\u0159esn\u011b charakterizovat; d\u00edky tomu je mazdutid u\u017eite\u010dnou modelovou slou\u010deninou v komparativn\u00edm v\u00fdzkumu peptid\u016f a v analytick\u00fdch studi\u00edch chov\u00e1n\u00ed dlouh\u00fdch acylovan\u00fdch \u0159et\u011bzc\u016f.<\/p>\n<h2>Aplikace v laboratorn\u00edm kontextu<\/h2>\n<p>V r\u00e1mci peptidov\u00e9 chemie a analytick\u00fdch prac\u00ed se mazdutid nach\u00e1z\u00ed mimo jin\u00e9 v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdzkum vztahu struktura-aktivita<\/strong> k p\u0159\u00edsp\u011bvku jednotliv\u00fdch pozic v sekvenci a acyla\u010dn\u00edho m\u00edsta k prostorov\u00e9mu pl\u00e1nov\u00e1n\u00ed a rigidit\u011b \u0159et\u011bzce.<\/li>\n<li><strong>V\u00fdzkum peptidov\u00e9 chemie<\/strong> t\u00fdkaj\u00edc\u00ed se rozpustnosti, amfifiln\u00edho chov\u00e1n\u00ed a agregace acylovan\u00fdch \u0159et\u011bzc\u016f ve vodn\u00e9m a sm\u011bsn\u00e9m prost\u0159ed\u00ed a vlivu pH a iontov\u00e9 s\u00edly na to.<\/li>\n<li><strong>Studie enzymatick\u00e9 stability<\/strong> ve kter\u00e9m je rychlost degradace \u0159et\u011bzce in vitro porovn\u00e1na s rychlost\u00ed degradace neacylovan\u00fdch analog\u016f za \u00fa\u010delem kvantifikace p\u0159\u00edsp\u011bvku mastn\u00e9 kyseliny ke stabilit\u011b \u0159et\u011bzce.<\/li>\n<li><strong>V\u00fdvoj a validace analytick\u00fdch metod<\/strong> (HPLC, LC-MS, mapov\u00e1n\u00ed peptid\u016f), kde materi\u00e1l slou\u017e\u00ed jako referen\u010dn\u00ed standard pro reten\u010dn\u00ed chov\u00e1n\u00ed, distribuci n\u00e1boje a fragmentov\u00e9 vzorce dlouh\u00fdch acylovan\u00fdch peptid\u016f.<\/li>\n<\/ul>\n<h2>Specifikace<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Ochutnat<\/strong><\/td>\n<td>Mazdutid, 10 mg na lahvi\u010dku<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>2259884-03-0<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/strong><\/td>\n<td>C<sub>210<\/sub>H<sub>322<\/sub>N<sub>46<\/sub>O<sub>67<\/sub> \u2014 p\u0159ibli\u017en\u011b 4563 let<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u0159\u00edda<\/strong><\/td>\n<td>Syntetick\u00fd acylovan\u00fd polypeptid (lipopeptid)<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1\u0159<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ek v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td>Lyofilizov\u00e1no p\u0159i 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Materi\u00e1l se dod\u00e1v\u00e1 jako lyofilizovan\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t) v uzav\u0159en\u00e9 sklen\u011bn\u00e9 lahvi\u010dce s pry\u017eovou p\u0159ep\u00e1\u017ekou a hlin\u00edkov\u00fdm smr\u0161\u0165ovac\u00edm uz\u00e1v\u011brem. Lyofilizovan\u00fd kol\u00e1\u010d je b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd a jeho hustota se m\u016f\u017ee v jednotliv\u00fdch lahvi\u010dk\u00e1ch li\u0161it; tato zm\u011bna je vlastn\u00ed procesu lyofilizace a nevypov\u00edd\u00e1 nic o kvalit\u011b materi\u00e1lu. Lyofiliz\u00e1ty acylovan\u00fdch peptid\u016f jsou hygroskopick\u00e9, a proto lahvi\u010dka z\u016fst\u00e1v\u00e1 uzav\u0159en\u00e1 a v p\u016fvodn\u00edm obalu, dokud nen\u00ed materi\u00e1l zpracov\u00e1n v laborato\u0159i.<\/p>\n<p>Uzav\u0159en\u00fd lyofiliz\u00e1t skladujte p\u0159i teplot\u011b 2\u20138 \u00b0C na tmav\u00e9m a such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem, vlhkost\u00ed a teplotn\u00edmi v\u00fdkyvy. P\u0159ed otev\u0159en\u00edm nechte chlazenou lahvi\u010dku dos\u00e1hnout pokojov\u00e9 teploty, aby se zabr\u00e1nilo kondenzaci na pr\u00e1\u0161ku. S materi\u00e1lem manipulujte dle obvykl\u00fdch laboratorn\u00edch opat\u0159en\u00ed: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte rukavice a ochranu o\u010d\u00ed a zbytkov\u00fd materi\u00e1l zlikvidujte v souladu s platn\u00fdmi pokyny.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>V p\u0159\u00edpad\u011b dlouh\u00e9ho acylovan\u00e9ho \u0159et\u011bzce ur\u010duje identita a \u010distota v\u00fdchoz\u00edho materi\u00e1lu, jak interpretovateln\u00e1 je s\u00e9rie m\u011b\u0159en\u00ed: dele\u010dn\u00ed sekvence a neacylovan\u00e9 varianty se velmi podobaj\u00ed c\u00edlov\u00e9 slou\u010denin\u011b, ale poskytuj\u00ed anom\u00e1ln\u00ed analytick\u00fd sign\u00e1l. N\u00e1\u0161 Mazdutid se dod\u00e1v\u00e1 s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v souladu s p\u0159ilo\u017een\u00fdm analytick\u00fdm certifik\u00e1tem. Dostupn\u00e9 analytick\u00e9 certifik\u00e1ty si m\u016f\u017eete prohl\u00e9dnout na na\u0161ich webov\u00fdch str\u00e1nk\u00e1ch. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<h2>D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed<\/h2>\n<p>Tento produkt dod\u00e1v\u00e1me v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum a analytick\u00e9 pr\u00e1ce. Nen\u00ed ur\u010den pro diagnostick\u00e9 ani terapeutick\u00e9 aplikace a v\u00fdslovn\u011b nen\u00ed ur\u010den k pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Tento produkt nen\u00ed potravinou, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani registrovan\u00fdm l\u00e9\u010div\u00fdm p\u0159\u00edpravkem. Zakoupen\u00edm tohoto produktu kupuj\u00edc\u00ed potvrzuje, \u017ee je star\u0161\u00ed 18 let a bude jej pou\u017e\u00edvat v\u00fdhradn\u011b v kontrolovan\u00e9m v\u00fdzkumn\u00e9m nebo laboratorn\u00edm prost\u0159ed\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Mazdutid je syntetick\u00fd acylovan\u00fd polypeptid (C<sub>210<\/sub>H<sub>322<\/sub>N<sub>46<\/sub>O<sub>67<\/sub>, p\u0159ibli\u017en\u011b 4563 g\/mol), ve kter\u00e9m je mastn\u00e1 kyselina s dlouh\u00fdm \u0159et\u011bzcem kovalentn\u011b v\u00e1z\u00e1na na lysinov\u00fd postrann\u00ed \u0159et\u011bzec prost\u0159ednictv\u00edm linkeru. V r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu je studov\u00e1na jako modelov\u00e1 slou\u010denina v peptidov\u00e9 chemii a analytick\u00fdch prac\u00edch. Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nikoli pro pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3306,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[117,121],"product_tag":[],"class_list":["post-2609","product","type-product","status-publish","has-post-thumbnail","product_cat-metabool-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2609"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2609\/revisions"}],"predecessor-version":[{"id":2688,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2609\/revisions\/2688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3306"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2609"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2609"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2609"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}