Pinealon is a synthetic short peptide from the group of Khavinson bioregulators, chemically a tripeptide composed of glutamic acid, aspartic acid, and arginine. In scientific research, it is studied as a model compound for peptide-nucleic acid interaction and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 20 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
Pinealone (L-alpha-glutamyl-L-alpha-aspartyl-L-arginine, sequence Glu-Asp-Arg, in the literature code EDR) is a linear tripeptide with the molecular formula C15<\/sub>H26<\/sub>N6<\/sub>O8<\/sub> and a molecular weight of 418.40 Da. The chain combines two acidic side chains\u2014glutamic acid and aspartic acid\u2014with the strongly basic arginine, causing the molecule to carry both negative and positive charge density over a very short distance. This charge distribution in just three amino acids makes the compound a widely used model for the interaction between short peptides and charged biopolymers.<\/p>\n In research models, Pinealon is studied as a ligand for double-stranded DNA: spectroscopy and molecular modeling describe how short peptides with this amino acid configuration target specific nucleotide sequences in the major groove of the double helix in vitro. In cell models, it is subsequently investigated whether such binding is associated with changes in chromatin packing\u2014the transition from densely packed heterochromatin to more accessible euchromatin\u2014and thereby with the transcription of specific genes. This working hypothesis from the Khavinson research line has so far been investigated primarily in vitro and in preclinical models. Consequently, Pinealon is used within scientific research as a model compound and reference substance.<\/p>\n In a laboratory context, Pinealon occurs in the following research areas, among others:<\/p>\n Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n Pinealon falls under the category of freeze-dried peptides in vial form within our range. Researchers in this category regularly combine the compound with other short peptides that are studied via their own biochemical target. While Pinealon focuses on the interaction between a short peptide and nucleic acids, other components in the same product line have been chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried form but differ fundamentally in chain length and investigated mechanism.<\/p>\n Pinealon is supplied as a freeze-dried powder, standardized to 20 mg per vial. Unlike a solid tablet form, a lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work; the dry state serves the stability of the peptide chain during transport and storage.<\/p>\n Store the unopened vial refrigerated, protected from direct light and moisture, in the original packaging; for longer periods, the dry lyophilisate should be stored frozen. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n This lyophilisate has a controlled purity of \u2265 99% (HPLC), determined on the peptide chain Glu-Asp-Arg. The vial contains exclusively the freeze-dried peptide.<\/p>\nOblasti v\u00fdzkumu<\/h2>\n
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Pinealon in our research assortment<\/h2>\n
Specifikace<\/h2>\n
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\n \nSpecifikace<\/th>\n Hodnota<\/th>\n<\/tr>\n<\/thead>\n \n Ochutnat<\/td>\n Pinealon<\/td>\n<\/tr>\n \n Synonyma<\/td>\n L-alpha-glutamyl-L-alpha-aspartyl-L-arginine; Glu-Asp-Arg; EDR peptide<\/td>\n<\/tr>\n \n \u010c\u00edslo CAS<\/td>\n 175175-23-2<\/td>\n<\/tr>\n \n Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n C15<\/sub>H26<\/sub>N6<\/sub>O8<\/sub> \/ 418.40 Da<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 10273502<\/td>\n<\/tr>\n \n T\u0159\u00edda<\/td>\n Synthetic tripeptide, short peptide bioregulator (cytogen)<\/td>\n<\/tr>\n \n Formul\u00e1\u0159<\/td>\n Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ek)<\/td>\n<\/tr>\n \n Quantity per bottle<\/td>\n 20 mg<\/td>\n<\/tr>\n \n Skladov\u00e1n\u00ed<\/td>\n Uchov\u00e1vejte v chladni\u010dce, chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n
Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\n