HGH Fragment 176-191 is a synthetic peptide fragment, chemically a chain of sixteen amino acids corresponding to the C-terminal part of somatotropin. Within scientific research, it is studied as a model compound for receptor and signal transduction research and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 5 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
HGH Fragment 176-191, systematically described as somatotropin (176-191), has the sequence Phe-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe. The two cysteine \u200b\u200bresidues at positions 7 and 14 form an intramolecular disulfide bridge, causing the fragment to assume a closed loop that approximates the spatial orientation of the C-terminal part of the parent molecule. This combination of short chain length and fixed conformation makes the compound a workable model for the question of which substructures of a large protein hormone carry which interaction.<\/p>\n
In research models, the fragment clearly distinguishes itself from the complete somatotropin molecule: it does not activate the classical growth hormone receptor, and in preclinical models, phosphorylation of STAT5 and induction of IGF-1 are not observed. In vitro, however, the compound is investigated in adipocyte cell models, focusing on signaling via \u03b23-adrenergic receptor subtypes and the associated cAMP\/PKA cascade. This decoupling of two signaling pathways within a single parent molecule makes the fragment mechanistically interesting. Consequently, HGH Fragment 176-191 is used as a model compound and reference substance within scientific research.<\/p>\n
In a laboratory context, HGH Fragment 176-191 occurs in the following research areas, among others:<\/p>\n
Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n
HGH Fragment 176-191 falls under the category of freeze-dried peptides in vials within our range. Researchers in this category regularly combine the compound with other peptides that are studied via their own biochemical target. While this fragment focuses on receptor signaling outside the classical growth hormone pathway, other components within the same product line have been specifically chosen to cover divergent receptor families or enzymatic pathways. These compounds share the freeze-dried form but differ fundamentally in amino acid sequence and investigated mechanism.<\/p>\n
| Specifikace<\/th>\n | Hodnota<\/th>\n<\/tr>\n<\/thead>\n | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ochutnat<\/td>\n | HGH Fragment 176-191<\/td>\n<\/tr>\n | ||||||||||
| Synonyma<\/td>\n | Somatotropin (176-191); hGH (176-191); hGH fragment 176-191<\/td>\n<\/tr>\n | ||||||||||
| \u010c\u00edslo CAS<\/td>\n | 66004-57-7<\/td>\n<\/tr>\n | ||||||||||
| Molekul\u00e1rn\u00ed vzorec \/ hmotnost<\/td>\n | C78<\/sub>H123<\/sub>N23<\/sub>O22<\/sub>S2<\/sub> \/ 1799,1 Da<\/td>\n<\/tr>\n| PubChem CID<\/td>\n | 16131230<\/td>\n<\/tr>\n | T\u0159\u00edda<\/td>\n | Peptide fragment of sixteen amino acids, C-terminal part of somatotropin<\/td>\n<\/tr>\n | Formul\u00e1\u0159<\/td>\n | Lyophilisate (freeze-dried powder) in vial<\/td>\n<\/tr>\n | Quantity per bottle<\/td>\n | 5 mg<\/td>\n<\/tr>\n | Skladov\u00e1n\u00ed<\/td>\n | Uchov\u00e1vejte v chladni\u010dce, chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n | Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\nHGH Fragment 176-191 is supplied as a freeze-dried powder with a standardized quantity of 5 mg per vial. As with all lyophilized materials, the material is most stable in the dry state; for analytical work, it is dissolved in a laboratory setup with a suitable solvent. Cysteine-containing peptides are susceptible to oxidation in this process.<\/p>\n Store the vial refrigerated, protected from direct light and moisture, in the original packaging. Observe the usual laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n Slo\u017een\u00ed a laboratorn\u00ed v\u00fdsledky<\/h2>\nFor this compound, a controlled purity of \u2265 99% (HPLC) is maintained, as is customary for freeze-dried peptides serving as reference material.<\/p>\n |