{"id":2409,"date":"2026-09-01T09:01:43","date_gmt":"2026-09-01T09:01:43","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2409"},"modified":"2026-09-02T09:01:13","modified_gmt":"2026-09-02T09:01:13","slug":"adamax-neusspray-kit","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/cs\/product\/adamax-neusspray-kit\/","title":{"rendered":"Sada nosn\u00edho spreje Adamax"},"content":{"rendered":"<p><strong>Pouze pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely. Nen\u00ed ur\u010deno pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed.<\/strong><\/p>\n<p>Adamax je syntetick\u00fd, termin\u00e1ln\u011b modifikovan\u00fd peptidov\u00fd analog z rodiny peptid\u016f ACTH(4\u201310), kter\u00fd je studov\u00e1n v kontrolovan\u00fdch laboratorn\u00edch podm\u00ednk\u00e1ch v kontextu peptidem zprost\u0159edkovan\u00fdch sign\u00e1ln\u00edch drah a molekul\u00e1rn\u00edch regula\u010dn\u00edch syst\u00e9m\u016f. Ve v\u011bdeck\u00e9m v\u00fdzkumu se tato slou\u010denina pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a jako referen\u010dn\u00ed standard v analytick\u00e9 pr\u00e1ci. Tato v\u00fdzkumn\u00e1 sada obsahuje 5 mg lyofilizovan\u00e9ho lyofiliz\u00e1tu v uzav\u0159en\u00e9 lahvi\u010dce se steriln\u00edm fyziologick\u00fdm roztokem (NaCl 0,9 %) a rozpra\u0161ova\u010dem.<\/p>\n<h2>Co je Adamax?<\/h2>\n<p>Adamax je konstruov\u00e1n kolem heptapeptidov\u00e9 z\u00e1kladn\u00ed sekvence Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), kter\u00e1 je sama odvozena z fragmentu ACTH(4\u201310). K tomuto j\u00e1dru byly p\u0159id\u00e1ny termin\u00e1ln\u00ed modifikace: N-termin\u00e1ln\u00ed acetylov\u00e1 skupina a modifikovan\u00fd C-termin\u00e1ln\u00ed konec. Toto st\u00edn\u011bn\u00ed obou konc\u016f \u0159et\u011bzce m\u011bn\u00ed n\u00e1bojov\u00fd profil molekuly a sni\u017euje vazebnou kapacitu exopeptid\u00e1z k termin\u00e1ln\u00edm peptidov\u00fdm vazb\u00e1m v syst\u00e9mech in vitro. Literatura nen\u00ed jednozna\u010dn\u00e1 ohledn\u011b p\u0159esn\u00e9ho slo\u017een\u00ed C-termin\u00e1ln\u00edho fragmentu; proto jsou n\u00ed\u017ee uvedeny pouze ov\u011b\u0159iteln\u00e9 strukturn\u00ed \u00fadaje.<\/p>\n<p>Ve v\u00fdzkumn\u00fdch modelech je Adamax studov\u00e1n ve vztahu k peptidov\u011b zprost\u0159edkovan\u00fdm sign\u00e1ln\u00edm drah\u00e1m a molekul\u00e1rn\u00edm regula\u010dn\u00edm mechanism\u016fm v bun\u011b\u010dn\u00fdch kultur\u00e1ch. Proto\u017ee molekula sd\u00edl\u00ed z\u00e1kladn\u00ed sekvenci s dob\u0159e charakterizovanou referen\u010dn\u00ed slou\u010deninou, ale li\u0161\u00ed se na obou konc\u00edch, slou\u017e\u00ed jako srovn\u00e1vac\u00ed vstup ve v\u00fdzkumu vztahu struktura-aktivita: pozorovan\u00e9 rozd\u00edly v analytick\u00e9m chov\u00e1n\u00ed lze p\u0159ipsat termin\u00e1ln\u00edm skupin\u00e1m. Adamax se proto pou\u017e\u00edv\u00e1 jako modelov\u00e1 slou\u010denina a referen\u010dn\u00ed l\u00e1tka ve v\u011bdeck\u00e9m v\u00fdzkumu.<\/p>\n<h2>Oblasti v\u00fdzkumu<\/h2>\n<p>V laboratorn\u00edm kontextu se Adamax vyskytuje v n\u00e1sleduj\u00edc\u00edch oblastech v\u00fdzkumu:<\/p>\n<ul>\n<li>V\u00fdzkum vztahu struktury a aktivity termin\u00e1ln\u011b modifikovan\u00fdch analog\u016f z\u00e1kladn\u00ed sekvence ACTH(4\u201310).<\/li>\n<li>Studie peptidem zprost\u0159edkovan\u00fdch sign\u00e1ln\u00edch drah a molekul\u00e1rn\u00edch regula\u010dn\u00edch s\u00edt\u00ed v kontrolovan\u00fdch bun\u011b\u010dn\u00fdch modelech in vitro.<\/li>\n<li>Vliv N-termin\u00e1ln\u00ed acetylace na konformaci, distribuci n\u00e1boje a rozpustnost kr\u00e1tk\u00fdch peptidov\u00fdch \u0159et\u011bzc\u016f.<\/li>\n<li>Srovn\u00e1vac\u00ed studie stability rychlosti degradace modifikovan\u00fdch a nemodifikovan\u00fdch \u0159et\u011bzc\u016f v enzymatick\u00fdch in vitro testech.<\/li>\n<li>Modelov\u00e1n\u00ed interakce receptor\u016f v r\u00e1mci rodiny peptid\u016f souvisej\u00edc\u00edch s melanokortinem za definovan\u00fdch podm\u00ednek.<\/li>\n<li>V\u00fdvoj a validace analytick\u00fdch metod (HPLC, LC-MS, UV detekce), kde peptid slou\u017e\u00ed jako referen\u010dn\u00ed vstup.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u011bchto aplikac\u00ed zahrnuje kontrolovan\u00fd laboratorn\u00ed nebo preklinick\u00fd modelov\u00fd v\u00fdzkum.<\/p>\n<h2>Analytick\u00e1 specifikace<\/h2>\n<p>Materi\u00e1l je p\u0159edkl\u00e1d\u00e1n s kontrolovanou \u010distotou \u2265 99 %, stanovenou pomoc\u00ed vysokotlak\u00e9 kapalinov\u00e9 chromatografie (HPLC). Identita a \u010distota jsou ur\u010duj\u00edc\u00edmi parametry v analytick\u00e9 pr\u00e1ci s peptidy: ne\u00fapln\u011b modifikovan\u00e9 \u0159et\u011bzce se strukturn\u011b li\u0161\u00ed od c\u00edlov\u00e9 slou\u010deniny jen nepatrn\u011b, a proto mohou b\u00fdt zahrnuty do chromatografick\u00fdch m\u011b\u0159en\u00ed. Zejm\u00e9na u molekuly, kde rozd\u00edl spo\u010d\u00edv\u00e1 v termin\u00e1ln\u00edch skupin\u00e1ch, \u010distota ur\u010duje, zda lze pozorovan\u00fd rozd\u00edl p\u0159ipsat t\u00e9to modifikaci. P\u0159ehled dostupn\u00e9 analytick\u00e9 dokumentace naleznete na na\u0161ich webov\u00fdch str\u00e1nk\u00e1ch. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledky laboratorn\u00edch test\u016f<\/a>.<\/p>\n<h2>Specifikace<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikace<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorek<\/td>\n<td>Adamax<\/td>\n<\/tr>\n<tr>\n<td>Synonyma<\/td>\n<td>Analog N-acetyl-MEHFPGP; termin\u00e1ln\u011b modifikovan\u00fd analog ACTH(4\u201310)<\/td>\n<\/tr>\n<tr>\n<td>J\u00e1drov\u00e1 sekvence<\/td>\n<td>Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) s N-termin\u00e1ln\u00ed acetylac\u00ed a C-termin\u00e1ln\u00ed modifikac\u00ed<\/td>\n<\/tr>\n<tr>\n<td>Struktur\u00e1ln\u00ed referen\u010dn\u00ed materi\u00e1l<\/td>\n<td>MEHFPGP, ACTH(4\u20137)-Pro-Gly-Pro \u2014 PubChem CID 9811102; CAS 80714-61-0; C<sub>37<\/sub>H<sub>51<\/sub>N<sub>9<\/sub>O<sub>10<\/sub>S; 813,9 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>T\u0159\u00edda<\/td>\n<td>Syntetick\u00fd, termin\u00e1ln\u011b modifikovan\u00fd peptidov\u00fd analog<\/td>\n<\/tr>\n<tr>\n<td>Forma<\/td>\n<td>Lyofilizovan\u00fd lyofiliz\u00e1t v uzav\u0159en\u00e9 lahvi\u010dce s fyziologick\u00fdm roztokem a rozpra\u0161ova\u010dem<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estv\u00ed na lahvi\u010dku<\/td>\n<td>5 mg<\/td>\n<\/tr>\n<tr>\n<td>\u010cistota<\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td>Skladov\u00e1n\u00ed<\/td>\n<td>Skladujte na chladn\u00e9m a tmav\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipulace a skladov\u00e1n\u00ed<\/h2>\n<p>Adamax se dod\u00e1v\u00e1 jako 5mg lyofiliz\u00e1t lyofiliz\u00e1t lyofilizovan\u00fd lyofiliz\u00e1tem v uzav\u0159en\u00e9 lahvi\u010dce s fyziologick\u00fdm roztokem a rozpra\u0161ova\u010dem. Lyofiliza\u010dn\u00ed proces zachov\u00e1v\u00e1 molekul\u00e1rn\u00ed integritu peptidov\u00e9ho \u0159et\u011bzce b\u011bhem skladov\u00e1n\u00ed a p\u0159epravy. Materi\u00e1l je b\u00edl\u00fd a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00fd; b\u011bhem lyofilizace doch\u00e1z\u00ed k drobn\u00fdm odchylk\u00e1m ve tvaru kol\u00e1\u010de, kter\u00e9 neznamenaj\u00ed kvalitu ani vadu.<\/p>\n<p>Uzav\u0159en\u00fd lyofiliz\u00e1t skladujte na chladn\u00e9m, such\u00e9m a tmav\u00e9m m\u00edst\u011b v p\u016fvodn\u00edm obalu, chr\u00e1n\u011bn\u00e9m p\u0159ed sv\u011btlem a vlhkost\u00ed; zb\u00fdvaj\u00edc\u00ed \u010d\u00e1sti uchov\u00e1vejte uzav\u0159en\u00e9 a\u017e do pou\u017eit\u00ed. Dodr\u017eujte obvykl\u00e1 laboratorn\u00ed opat\u0159en\u00ed: pracujte v \u010dist\u00e9m prost\u0159ed\u00ed, pou\u017e\u00edvejte vhodn\u00e9 osobn\u00ed ochrann\u00e9 prost\u0159edky, zabra\u0148te k\u0159\u00ed\u017eov\u00e9 kontaminaci s jin\u00fdmi v\u00fdzkumn\u00fdmi materi\u00e1ly a uchov\u00e1vejte obal mimo dosah neopr\u00e1vn\u011bn\u00fdch osob. Zbytky materi\u00e1lu zlikvidujte v souladu s platn\u00fdmi laboratorn\u00edmi pokyny.<\/p>\n<h2>Adamax v na\u0161\u00ed v\u00fdzkumn\u00e9 \u0159ad\u011b<\/h2>\n<p>Adamax spad\u00e1 do kategorie lyofilizovan\u00fdch experiment\u00e1ln\u00edch slou\u010denin dod\u00e1van\u00fdch jako souprava v na\u0161\u00ed nab\u00eddce. V\u00fdzkumn\u00edci pravideln\u011b kombinuj\u00ed tuto slou\u010deninu s jin\u00fdmi peptidy, kter\u00e9 jsou studov\u00e1ny prost\u0159ednictv\u00edm jejich vlastn\u00edho molekul\u00e1rn\u00edho c\u00edle. Zat\u00edmco Adamax se vyzna\u010duje termin\u00e1ln\u00ed modifikac\u00ed kr\u00e1tk\u00e9, dob\u0159e charakterizovan\u00e9 z\u00e1kladn\u00ed sekvence, dal\u0161\u00ed slo\u017eky ve stejn\u00e9 produktov\u00e9 \u0159ad\u011b byly speci\u00e1ln\u011b vybr\u00e1ny tak, aby pokryly c\u00edle v\u00e1zan\u00e9 na kov, receptor nebo enzymatick\u00e9 c\u00edle. Sd\u00edlej\u00ed lyofilizovanou formu pod\u00e1n\u00ed, ale li\u0161\u00ed se molekul\u00e1rn\u00ed t\u0159\u00eddou a zkouman\u00fdm mechanismem.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do kter\u00e9 t\u0159\u00eddy l\u00e1tek pat\u0159\u00ed Adamax?<\/strong><br \/>Syntetick\u00fd peptidov\u00fd analog, konstruovan\u00fd kolem z\u00e1kladn\u00ed sekvence Met-Glu-His-Phe-Pro-Gly-Pro z rodiny ACTH(4\u201310) a vyzna\u010duj\u00edc\u00ed se termin\u00e1ln\u00edmi modifikacemi na obou konc\u00edch \u0159et\u011bzce.<\/p>\n<p><strong>Pro\u010d jsou modifikace termin\u00e1l\u016f relevantn\u00ed ve v\u00fdzkumu?<\/strong><br \/>D\u00e1vaj\u00ed molekule definovan\u00fd, dob\u0159e charakterizovateln\u00fd profil, kter\u00fd se li\u0161\u00ed od zn\u00e1m\u00e9 referen\u010dn\u00ed sekvence p\u0159esn\u011b ve dvou bodech. D\u00edky tomu je slou\u010denina u\u017eite\u010dn\u00e1 ve v\u00fdzkumu vztahu mezi strukturou a aktivitou a ve srovn\u00e1vac\u00edch analytick\u00fdch metod\u00e1ch.<\/p>\n<p><strong>What color is the material?<\/strong><br \/>B\u00edl\u00e1 a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00e1. B\u011bhem lyofilizace se mohou vyskytovat drobn\u00e9 rozd\u00edly ve tvaru t\u011bsta, co\u017e je norm\u00e1ln\u00ed.<\/p>\n<p><strong>Co sada obsahuje?<\/strong><br \/>Uzav\u0159en\u00e1 lahvi\u010dka obsahuj\u00edc\u00ed 5 mg \u2265 99% lyofiliz\u00e1tu (HPLC), steriln\u00ed fyziologick\u00fd roztok (0,9% NaCl) a rozpra\u0161ova\u010d.<\/p>\n<p><strong>Jak m\u00e1m materi\u00e1l skladovat?<\/strong><br \/>Store in a cool, dry, and dark place in the original packaging, protected from light and moisture.<\/p>","protected":false},"excerpt":{"rendered":"<p>V\u00fdzkumn\u00e1 sada s lyofilizovan\u00fdm Adamaxem (experiment\u00e1ln\u00ed peptid z rodiny analog\u016f Semax\/ACTH) 5 mg a steriln\u00edm fyziologick\u00fdm roztokem (NaCl 0,9 %) \u2013 \u010distota \u226599 % (HPLC). Ur\u010deno v\u00fdhradn\u011b pro laboratorn\u00ed a v\u00fdzkumn\u00e9 \u00fa\u010dely; nen\u00ed ur\u010deno k lidsk\u00e9 ani zv\u00ed\u0159ec\u00ed spot\u0159eb\u011b. Nen\u00ed to l\u00e9\u010div\u00fd p\u0159\u00edpravek.<\/p>","protected":false},"featured_media":3104,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[133,131],"product_tag":[],"class_list":["post-2409","product","type-product","status-publish","has-post-thumbnail","product_cat-focus-cognitie","product_cat-neussprays","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/comments?post=2409"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2409\/revisions"}],"predecessor-version":[{"id":2477,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product\/2409\/revisions\/2477"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media\/3104"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/media?parent=2409"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_brand?post=2409"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_cat?post=2409"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/cs\/wp-json\/wp\/v2\/product_tag?post=2409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}