CJC-1295 + Ipamorelin Pen

CJC-1295 without DAC and Ipamorelin are two synthetic peptides that each act on a specific receptor of the pituitary axis in research models. Within scientific research, they are studied together as a model pair for the interaction between two release pathways and as a reference standard in analytical work. This combination is offered as a 3 ml pre-filled injection pen containing 5 mg of each peptide, exclusively for laboratory and research purposes.

What is inside this pen?

The cartridge contains both peptides in a fixed 1:1 ratio, pre-combined in a single solution. CJC-1295 without DAC, also known in the literature as Mod GRF(1-29), is a modified fragment of 29 amino acids of the growth hormone-releasing hormone. Four amino acid substitutions at positions 2, 8, 15, and 27 make the chain more resistant to enzymatic degradation than the unmodified GRF(1-29); binding to the GHRH receptor is studied in research models.

Ipamorelin is a selective pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂ which acts on the growth hormone secretagogue receptor, also known as the ghrelin receptor. The two D-amino acids and the non-proteinogenic Aib at the start of the chain make the compound insensitive to the usual degradation pathways and provide a pronounced selectivity profile with respect to related secretagogues. Because both molecules act via a different receptor, pairing is considered in the literature as a classic model for studying the interplay between two signaling pathways.

Oblasti výzkumu

In a laboratory context, this combination occurs in the following research areas, among others:

• Receptor pharmacology — binding studies to the GHRH receptor and the growth hormone secretagogue receptor in cell models.
• Signal transduction — measurement of second messenger systems with simultaneous activation of both routes.
• Selectivity study — comparison with related secretagogues to determine the receptor specificity of the pentapeptide.
• Structure-activity research — the role of D-amino acids and Aib in the resistance of short chains to peptidases.
• Analytical method development — separation of two peptides from a single solution using RP-HPLC and LC-MS.
• Stability study — behavior of a two-component solution at varying pH, ionic strength, and storage temperature.

Každá z těchto aplikací zahrnuje kontrolovaný laboratorní nebo preklinický modelový výzkum.

CJC-1295 + Ipamorelin in our research assortment

This version belongs to the line of pre-filled injection pens: compounds contained in dissolved form in a sealed cartridge, so that a researcher does not need to go through their own dissolution step. The same combination is available elsewhere in the range as freeze-dried lyophilisate in a vial, and both peptides are also available separately. Other compounds within the pen line act on an entirely different biochemical system; the form indicates nothing about the substance class.

Specifikace

Tvar, manipulace a skladování

Both peptides are dissolved in a sealed 3 ml glass cartridge in a pen with a click mechanism. A separate dissolution step is not required with this version; the cartridge remains closed until a needle is inserted. The label includes a table showing the relationship between click settings and dispensed volume, allowing sample collections to be reproducibly recorded in a protocol.

Store the pen refrigerated between 2 and 8 °C, protected from light and in the original packaging. Handle the pen in a clean working environment, use a new sterile needle for each draw to prevent cross-contamination, and wear standard personal protective equipment. Keep the material out of reach of unauthorized persons.

Složení a laboratorní výsledky

Both raw materials have a controlled purity of ≥ 99% (HPLC). The pen contains the two peptides in a sterile aqueous base in a 1:1 ratio; the total amount per component is stated on the label.

Analysis certificates of the relevant parties are on our stránka s výsledky laboratorních testů.

Často kladené otázky

To which class of substances do these two compounds belong?
CJC-1295 without DAC is a modified peptide fragment of 29 amino acids, derived from growth hormone-releasing hormone. Ipamorelin is a synthetic pentapeptide with two D-amino acids and an Aib residue at the start of the chain.

Co znamená „bez DAC“?
DAC stands for Drug Affinity Complex, a chemical additive that extends the chain circulation time in models. In the variant without DAC, this additive is absent, making the profile closer to that of the unprocessed GRF(1-29) fragment.

V jaké formě je kombinace dodávána?
As a pre-filled injection pen with a sealed 3 ml cartridge containing 5 mg of both peptides. The box also contains ten sterile pen needles and alcohol wipes.

How do I store the pen?
Refrigerated between 2 and 8 °C, in a dark place and in the original packaging. Do not freeze.